Browsing Harvard Medical School by Title
Now showing items 631-650 of 18428
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Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia
(2014)Many neurodegenerative diseases, such as frontotemporal dementia (FTD), are associated with behavioral deficits, but the anatomical and molecular bases remain poorly understood. Here we show that forebrain-specific expression ... -
Alterations of Serum Levels of BDNF-Related miRNAs in Patients with Depression
(Public Library of Science, 2013)Depression is a serious and potentially life-threatening mental disorder with unknown etiology. Emerging evidence shows that brain-derived neurotrophic factor (BDNF) and microRNAs (miRNAs) play critical roles in the etiology ... -
Alterations of the human gut microbiome in multiple sclerosis
(Nature Publishing Group, 2016)The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut microbiome in subjects with multiple sclerosis ... -
Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth
(Impact Journals LLC, 2016)We hypothesized that tumor-associated macrophages (TAMs) are controlled by the diffusible gas carbon monoxide (CO). We demonstrate that induction of apoptosis in lung tumors treated with low doses of CO is associated with ... -
Altered biochemical specificity of G-quadruplexes with mutated tetrads
(Oxford University Press, 2016)A fundamental motif in canonical nucleic acid structure is the base pair. Mutations that disrupt base pairs are typically destabilizing, but stability can often be restored by a second mutation that replaces the original ... -
Altered brain morphometry in carpal tunnel syndrome is associated with median nerve pathology☆☆☆
(Elsevier, 2013)Objective: Carpal tunnel syndrome (CTS) is a common median nerve entrapment neuropathy characterized by pain, paresthesias, diminished peripheral nerve conduction velocity (NCV) and maladaptive functional brain neuroplasticity. ... -
Altered Cholesterol Homeostasis in Aged Macrophages Linked to Neovascular Macular Degeneration
(Elsevier BV, 2013)Abnormal lipid metabolism has been linked to age-related macular degeneration (AMD); choroidal neovascularization in late AMD commonly causes blindness. Sene et al. (2013) now demonstrate that in aged macrophages decreased ... -
Altered Chromatin Occupancy of Master Regulators Underlies Evolutionary Divergence in the Transcriptional Landscape of Erythroid Differentiation
(Public Library of Science, 2014)Erythropoiesis is one of the best understood examples of cellular differentiation. Morphologically, erythroid differentiation proceeds in a nearly identical fashion between humans and mice, but recent evidence has shown ... -
Altered Chromosomal Topology Drives Oncogenic Programs in SDH-Deficient GISTs
(Springer Science and Business Media LLC, 2019-10-16)Epigenetic aberrations are widespread in cancer, yet the underlying mechanisms and causality remain poorly understood1-3. A subset of gastrointestinal stromal tumors (GISTs) lack canonical kinase mutations but instead have ... -
Altered Circadian Feeding Behavior and Improvement of Metabolic Syndrome in Obese Tac1-Deficient Mice
(Springer Science and Business Media LLC, 2017-12)BACKGROUND Metabolic function is regulated by the interplay of central and peripheral factors that ultimately regulate food intake and energy expenditure. The tachykinin substance P (SP) has been identified as a novel ... -
Altered distribution of mucosal NK cells during HIV infection
(2013)The human gut mucosa is a major site of HIV infection and infection-associated pathogenesis. Increasing evidence shows that natural killer (NK) cells play an important role in control of HIV infection but the mechanism(s) ... -
Altered expression of norepinephrine transporter and norepinephrine in human placenta cause pre-eclampsia through regulated trophoblast invasion
(The Korean Society for Reproductive Medicine, 2013)Objective: We investigated the norepinephrine transporter (NET) expression in normal and pre-eclamptic placentas and analyzed the invasion activity of trophoblastic cells based on norepinephrine (NE)-NET regulation. Methods: ... -
Altered expression of protein tyrosine phosphatase, non-receptor type 22 isoforms in systemic lupus erythematosus
(BioMed Central, 2014)Introduction: A C-to-T single nucleotide polymorphism (SNP) located at position 1858 of human protein tyrosine phosphatase, non-receptor type 22 (PTPN22) complementary DNA (cDNA) is associated with an increased risk of ... -
Altered Gene Expression Associated with microRNA Binding Site Polymorphisms
(Public Library of Science, 2015)Allele-specific gene expression associated with genetic variation in regulatory regions can play an important role in the development of complex traits. We hypothesized that polymorphisms in microRNA (miRNA) response ... -
Altered Gene Expression in Blood and Sputum in COPD Frequent Exacerbators in the ECLIPSE Cohort
(Public Library of Science, 2014)Patients with chronic obstructive pulmonary disease (COPD) who are defined as frequent exacerbators suffer with 2 or more exacerbations every year. The molecular mechanisms responsible for this phenotype are poorly understood. ... -
Altered Gray Matter Volume and White Matter Integrity in College Students with Mobile Phone Dependence
(Frontiers Media S.A., 2016)Mobile phone dependence (MPD) is a behavioral addiction that has become an increasing public mental health issue. While previous research has explored some of the factors that may predict MPD, the underlying neural mechanisms ... -
Altered Hypothalamic Functional Connectivity with Autonomic Circuits and the Locus Coeruleus in Migraine
(Public Library of Science, 2014)The hypothalamus has been implicated in migraine based on the manifestation of autonomic symptoms with the disease, as well as neuroimaging evidence of hypothalamic activation during attacks. Our objective was to determine ... -
Altered intrinsic functional coupling between core neurocognitive networks in Parkinson's disease
(Elsevier, 2015)Parkinson's disease (PD) is largely attributed to disruptions in the nigrostriatal dopamine system. These neurodegenerative changes may also have a more global effect on intrinsic brain organization at the cortical level. ... -
Altered kynurenine pathway metabolites in serum of chronic migraine patients
(Springer Milan, 2016)Background: Activation of glutamate (Glu) receptors plays a key role in the pathophysiology of migraine. Both NMDA and metabotropic Glu receptors are activated or inhibited by metabolites of the kynurenine pathway, such ... -
Altered language network activity in young people at familial high-risk for schizophrenia
(Elsevier BV, 2013)Background—Abnormalities in language and language neural circuitry are observed in schizophrenia (SZ). Similar, but less pronounced language deficits are also seen in young first degree relatives of people with SZ, who ...