Browsing Harvard Medical School by Title

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    • Altered brain morphometry in carpal tunnel syndrome is associated with median nerve pathology☆☆☆ 

      Maeda, Yumi; Kettner, Norman; Sheehan, James; Kim, Jieun; Cina, Stephen; Malatesta, Cristina; Gerber, Jessica; McManus, Claire; Mezzacappa, Pia; Morse, Leslie R.; Audette, Joseph; Napadow, Vitaly (Elsevier, 2013)
      Objective: Carpal tunnel syndrome (CTS) is a common median nerve entrapment neuropathy characterized by pain, paresthesias, diminished peripheral nerve conduction velocity (NCV) and maladaptive functional brain neuroplasticity. ...

    • Altered Cholesterol Homeostasis in Aged Macrophages Linked to Neovascular Macular Degeneration 

      Chen, Jing; Smith, Lois Elaine Hodgson (Elsevier BV, 2013)
      Abnormal lipid metabolism has been linked to age-related macular degeneration (AMD); choroidal neovascularization in late AMD commonly causes blindness. Sene et al. (2013) now demonstrate that in aged macrophages decreased ...

    • Altered Chromatin Occupancy of Master Regulators Underlies Evolutionary Divergence in the Transcriptional Landscape of Erythroid Differentiation 

      Ulirsch, Jacob C.; Lacy, Jessica N.; An, Xiuli; Mohandas, Narla; Mikkelsen, Tarjei S.; Sankaran, Vijay G. (Public Library of Science, 2014)
      Erythropoiesis is one of the best understood examples of cellular differentiation. Morphologically, erythroid differentiation proceeds in a nearly identical fashion between humans and mice, but recent evidence has shown ...

    • Altered Chromosomal Topology Drives Oncogenic Programs in SDH-Deficient GISTs 

      Flavahan, William A.; Drier, Yotam; Johnstone, Sarah E.; Hemming, Matthew; Tarjan, Daniel R.; Hegazi, Esmat; Shareef, Sarah; Javed, Nauman; Eschle, Benjamin K.; Gokhale, Prafulla C.; Hornick, Jason; Sicinska, Ewa; Demetri, George; Bernstein, Bradley (Springer Science and Business Media LLC, 2019-10-16)
      Epigenetic aberrations are widespread in cancer, yet the underlying mechanisms and causality remain poorly understood1-3. A subset of gastrointestinal stromal tumors (GISTs) lack canonical kinase mutations but instead have ...

    • Altered Circadian Feeding Behavior and Improvement of Metabolic Syndrome in Obese Tac1-Deficient Mice 

      Maguire, Caroline; Leon, Silvia; Carroll, Rona; Kaiser, Ursula; Navarro, Victor (Springer Science and Business Media LLC, 2017-12)
      BACKGROUND Metabolic function is regulated by the interplay of central and peripheral factors that ultimately regulate food intake and energy expenditure. The tachykinin substance P (SP) has been identified as a novel ...

    • Altered distribution of mucosal NK cells during HIV infection 

      Sips, Magdalena; Sciaranghella, Gaia; Diefenbach, Thomas; Dugast, Anne-Sophie; Berger, Christoph T.; Liu, Qingquan; Kwon, Douglas; Ghebremichael, Musie; Estes, Jacob D.; Carrington, Mary; Martin, Jeffrey N.; Deeks, Steven G.; Hunt, Peter W.; Alter, Galit (2013)
      The human gut mucosa is a major site of HIV infection and infection-associated pathogenesis. Increasing evidence shows that natural killer (NK) cells play an important role in control of HIV infection but the mechanism(s) ...

    • Altered expression of norepinephrine transporter and norepinephrine in human placenta cause pre-eclampsia through regulated trophoblast invasion 

      Na, Kyu-Hwan; Choi, Jong Ho; Kim, Chun-Hyung; Kim, Kwang-Soo; Kim, Gi Jin (The Korean Society for Reproductive Medicine, 2013)
      Objective: We investigated the norepinephrine transporter (NET) expression in normal and pre-eclamptic placentas and analyzed the invasion activity of trophoblastic cells based on norepinephrine (NE)-NET regulation. Methods: ...

    • Altered expression of protein tyrosine phosphatase, non-receptor type 22 isoforms in systemic lupus erythematosus 

      Chang, Hui-Hsin; Tseng, William; Cui, Jing; Costenbader, Karen; Ho, I-Cheng (BioMed Central, 2014)
      Introduction: A C-to-T single nucleotide polymorphism (SNP) located at position 1858 of human protein tyrosine phosphatase, non-receptor type 22 (PTPN22) complementary DNA (cDNA) is associated with an increased risk of ...

    • Altered Gene Expression Associated with microRNA Binding Site Polymorphisms 

      Võsa, Urmo; Esko, Tõnu; Kasela, Silva; Annilo, Tarmo (Public Library of Science, 2015)
      Allele-specific gene expression associated with genetic variation in regulatory regions can play an important role in the development of complex traits. We hypothesized that polymorphisms in microRNA (miRNA) response ...

    • Altered Gene Expression in Blood and Sputum in COPD Frequent Exacerbators in the ECLIPSE Cohort 

      Singh, Dave; Fox, Steven M.; Tal-Singer, Ruth; Bates, Stewart; Riley, John H.; Celli, Bartolome (Public Library of Science, 2014)
      Patients with chronic obstructive pulmonary disease (COPD) who are defined as frequent exacerbators suffer with 2 or more exacerbations every year. The molecular mechanisms responsible for this phenotype are poorly understood. ...

    • Altered Gray Matter Volume and White Matter Integrity in College Students with Mobile Phone Dependence 

      Wang, Yongming; Zou, Zhiling; Song, Hongwen; Xu, Xiaodan; Wang, Huijun; d’Oleire Uquillas, Federico; Huang, Xiting (Frontiers Media S.A., 2016)
      Mobile phone dependence (MPD) is a behavioral addiction that has become an increasing public mental health issue. While previous research has explored some of the factors that may predict MPD, the underlying neural mechanisms ...

    • Altered Hypothalamic Functional Connectivity with Autonomic Circuits and the Locus Coeruleus in Migraine 

      Moulton, Eric A.; Becerra, Lino; Johnson, Adriana; Burstein, Rami; Borsook, David (Public Library of Science, 2014)
      The hypothalamus has been implicated in migraine based on the manifestation of autonomic symptoms with the disease, as well as neuroimaging evidence of hypothalamic activation during attacks. Our objective was to determine ...

    • Altered intrinsic functional coupling between core neurocognitive networks in Parkinson's disease 

      Putcha, Deepti; Ross, Robert S.; Cronin-Golomb, Alice; Janes, Amy C.; Stern, Chantal E. (Elsevier, 2015)
      Parkinson's disease (PD) is largely attributed to disruptions in the nigrostriatal dopamine system. These neurodegenerative changes may also have a more global effect on intrinsic brain organization at the cortical level. ...

    • Altered kynurenine pathway metabolites in serum of chronic migraine patients 

      Curto, Martina; Lionetto, Luana; Negro, Andrea; Capi, Matilde; Fazio, Francesco; Giamberardino, Maria Adele; Simmaco, Maurizio; Nicoletti, Ferdinando; Martelletti, Paolo (Springer Milan, 2016)
      Background: Activation of glutamate (Glu) receptors plays a key role in the pathophysiology of migraine. Both NMDA and metabotropic Glu receptors are activated or inhibited by metabolites of the kynurenine pathway, such ...

    • Altered language network activity in young people at familial high-risk for schizophrenia 

      Thermenos, Heidi Wencel; Whitfield-Gabrieli, S.; Seidman, Larry Joel; Kuperberg, Gina Rosalind; Juelich, R.J.; Divatia, S.; Riley, C.; Jabbar, G.A.; Shenton, Martha Elizabeth; Kubicki, Marek R.; Manschreck, Theo Clyde; Keshavan, Matcheri S; DeLisi, Lynn E (Elsevier BV, 2013)
      Background—Abnormalities in language and language neural circuitry are observed in schizophrenia (SZ). Similar, but less pronounced language deficits are also seen in young first degree relatives of people with SZ, who ...

    • Altered Low Frequency Oscillations of Cortical Vessels in Patients with Cerebrovascular Occlusive Disease – A NIRS Study 

      Phillip, Dorte; Iversen, Helle K.; Schytz, Henrik W.; Selb, Juliette; Boas, David A.; Ashina, Messoud (Frontiers Media S.A., 2013)
      Analysis of cerebral autoregulation by measuring spontaneous oscillations in the low frequency spectrum of cerebral cortical vessels might be a useful tool for assessing risk and investigating different treatment strategies ...

    • Altered metabolic requirements in cancer cell migration and metastasis 

      Lee, Jaewon; Ng, Mei Rosa; Sinkevicius, Kerstin Wolf; Kim, Carla; Danuser, Gaudenz; Brugge, Joan S.; Haigis, Marcia C. (BioMed Central, 2012)

    • Altered Metabolism in Cancer 

      Locasale, Jason Wei; Cantley, Lewis C. (BioMed Central, 2010)
      Cancer cells have different metabolic requirements from their normal counterparts. Understanding the consequences of this differential metabolism requires a detailed understanding of glucose metabolism and its relation to ...

    • Altered Monocyte Phenotype in HIV-1 Infection Tends to Normalize with Integrase-Inhibitor-Based Antiretroviral Therapy 

      McCausland, Marie R.; Juchnowski, Steven M.; Zidar, David A.; Kuritzkes, Daniel R.; Andrade, Adriana; Sieg, Scott F.; Lederman, Michael M.; Funderburg, Nicholas T. (Public Library of Science, 2015)
      Background: Monocytes are increasingly implicated in the inflammatory consequences of HIV-1 disease, yet their phenotype following antiretroviral therapy (ART) initiation is incompletely defined. Here, we define more ...

    • Altered NK cell function in obese healthy humans 

      Laue, Tobias; Wrann, Christiane D; Hoffmann-Castendiek, Birgit; Pietsch, Daniel; Hübner, Lena; Kielstein, Heike (BioMed Central, 2015)
      Background: Obesity is associated with an elevated risk for several types of cancer and thus a major health hazard. However, the mechanism between overweight and cancer susceptibility is still elusive. Leptin, mainly ...