Browsing Harvard Medical School by Title
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Fried Food Consumption and Cardiovascular Health: A Review of Current Evidence
(MDPI, 2015)Fried food consumption and its effects on cardiovascular disease are still subjects of debate. The objective of this review was to summarize current evidence on the association between fried food consumption and cardiovascular ... -
Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies
(BMJ Publishing Group Ltd., 2014)Objective: To examine the interactions between genetic predisposition and consumption of fried food in relation to body mass index (BMI) and obesity. Design: Prospective cohort study. Setting: Health professionals in the ... -
Friend Turned Foe: Evolution of Enterococcal Virulence and Antibiotic Resistance
(Annual Reviews, 2014)The enterococci are an ancient genus that evolved along with the tree of life. These intrinsically rugged bacteria are highly adapted members of the intestinal consortia of a range of hosts that spans the animal kingdom. ... -
From bench to bedside: bipolar androgen therapy in a pilot clinical study
(Medknow Publications & Media Pvt Ltd, 2015)Prostate cancer remains a leading cause of cancer death in Europe and the United States and is an emerging problem in Asia despite significant improvements in available treatments over the last few decades. Androgen ... -
From Biological Cilia to Artificial Flow Sensors: Biomimetic Soft Polymer Nanosensors with High Sensing Performance
(Nature Publishing Group, 2016)We report the development of a new class of miniature all-polymer flow sensors that closely mimic the intricate morphology of the mechanosensory ciliary bundles in biological hair cells. An artificial ciliary bundle is ... -
From cell biology to the microbiome: An intentional infinite loop
(The Rockefeller University Press, 2015)Cell biology is the study of the structure and function of the unit or units of living organisms. Enabled by current and evolving technologies, cell biologists today are embracing new scientific challenges that span many ... -
From Cell Differentiation to Cell Collectives: Bacillus subtilis Uses Division of Labor to Migrate
(Public Library of Science, 2015)The organization of cells, emerging from cell–cell interactions, can give rise to collective properties. These properties are adaptive when together cells can face environmental challenges that they separately cannot. One ... -
From comorbidities of chronic obstructive pulmonary disease to identification of shared molecular mechanisms by data integration
(BioMed Central, 2016)Background: Deep mining of healthcare data has provided maps of comorbidity relationships between diseases. In parallel, integrative multi-omics investigations have generated high-resolution molecular maps of putative ... -
From following patients to following up: a new system for learning and patient care in a longitudinal integrated clerkship
(2015-06-08)BACKGROUND Longitudinal integrated clerkships (LICs) organize medical student learning around participation in patient care across multiple disciplines and over time. Clinical logbooks – which normally only document student ... -
From Genes to Networks: In Systematic Points of View
(BioMed Central, 2011)We present a report of the BIOCOMP'10 - The 2010 International Conference on Bioinformatics & Computational Biology and other related work in the area of systems biology. -
From Neurons to Circuits: Linear Estimation of Local Field Potentials
(Society for Neuroscience, 2009)Extracellular physiological recordings are typically separated into two frequency bands: local field potentials (LFPs) (a circuit property) and spiking multiunit activity (MUA). Recently, there has been increased interest ... -
From Next-Generation Sequencing Alignments to Accurate Comparison and Validation of Single-Nucleotide Variants: The Pibase Software
(Oxford University Press, 2012)Scientists working with single-nucleotide variants (SNVs), inferred by next-generation sequencing software, often need further information regarding true variants, artifacts and sequence coverage gaps. In clinical diagnostics, ... -
From scaling up to sustainability in HIV: potential lessons for moving forward
(BioMed Central, 2013)Background: In 30 years of experience in responding to the HIV epidemic, critical decisions and program characteristics for successful scale-up have been studied. Now leaders face a new challenge: sustaining large-scale ... -
From Semantics to Feelings: How Do Individuals with Schizophrenia Rate the Emotional Valence of Words?
(Hindawi Publishing Corporation, 2012)Schizophrenia is characterized by both emotional and language abnormalities. However, in spite of reports of preserved evaluation of valence of affective stimuli, such as pictures, it is less clear how individuals with ... -
From synapse to gene product: prolonged expression of c-fos induced by a single microinjection of carbachol in the pontomesencephalic tegmentum
(Elsevier BV, 2005)It is not known how the brain modifies its regulatory systems in response to the application of a drug, especially over the long term of weeks and months. We have developed a model system approach to this question by ... -
From systems biology to synthetic biology
(EMBO, 2005-01) -
From Tones in Tinnitus to Sensed Social Interaction in Schizophrenia: How Understanding Cortical Organization Can Inform the Study of Hallucinations and Psychosis
(Oxford University Press, 2014)The content, modality, and perceptual attributes of hallucinations and other psychotic symptoms may be related to neural representation at a single cell and population level in the cerebral cortex. A brief survey of some ... -
From transcriptional regulation to drugging the cancer epigenome
(BioMed Central, 2014)Jay Bradner discusses the opportunities and challenges for the study and therapeutic targeting of the cancer epigenome, as well as innovative approaches to drug discovery. -
Front Line Treatment of Elderly Multiple Myeloma in the Era of Novel Agents
(Dove Medical Press, 2009)Melphalan combined with prednisone (MP) has long been the historical treatment of reference for a large proportion of elderly myeloma (MM) patients ineligible for autologous stem cell transplantation, and is still the ...