Browsing Harvard Medical School by Title
Now showing items 6751-6770 of 18428
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Functional Multipotency of Stem Cells: A Conceptual Review of Neurotrophic Factor-Based Evidence and Its Role in Translational Research
(Bentham Science Publishers, 2011)We here propose an updated concept of stem cells (SCs), with an emphasis on neural stem cells (NSCs). The conventional view, which has touched principally on the essential property of lineage multipotency (e.g., the ability ... -
Functional Network Dynamics of the Language System
(Oxford University Press, 2016)During linguistic processing, a set of brain regions on the lateral surfaces of the left frontal, temporal, and parietal cortices exhibit robust responses. These areas display highly correlated activity while a subject ... -
Functional outcomes of acute medical illness and hospitalization in older persons
(American Medical Association (AMA), 1996)BACKGROUND: Short-stay hospitalization in older patients is frequently associated with a loss of function, which can lead to a need for postdischarge assistance and longer-term institutionalization. Because little is known ... -
Functional Perturbation of Classical Natural Killer and Innate Lymphoid Cells in the Oral Mucosa during SIV Infection
(Frontiers Media S. A., 2013)Despite the fact that the majority of human pathogens are transmitted across mucosal surfaces, including the oral mucosae, oral immunity is poorly understood. Furthermore, because the normal flora of the oral cavity is ... -
A Functional Polymorphism in the Epidermal Growth Factor Gene Independently Predicts Clinical Decompensation in HCV-Related Cirrhosis
(2014-07-07)Background and Aims: Several single nucleotide polymorphisms (SNPs), including rs4444903 in the epidermal growth factor (EGF) gene, rs12979860 near the interleukin-28B (IL28B) gene, and rs738409 in the patatin-like ... -
A functional polymorphism in the epidermal growth factor gene predicts hepatocellular carcinoma risk in Japanese hepatitis C patients
(Dove Medical Press, 2013)Background: A single nucleotide polymorphism (SNP) in the epidermal growth factor (EGF) gene (rs4444903) has been associated with increased risk of cancer, including hepatocellular carcinoma (HCC). The aim of this study ... -
Functional profiling of the gut microbiome in disease-associated inflammation
(BioMed Central, 2013)The microbial residents of the human gut are a major factor in the development and lifelong maintenance of health. The gut microbiota differs to a large degree from person to person and has an important influence on health ... -
Functional Properties and Toxin Pharmacology of a Dorsal Root Ganglion Sodium Channel Viewed through its Voltage Sensors
(The Rockefeller University Press, 2011)The voltage-activated sodium (Nav) channel Nav1.9 is expressed in dorsal root ganglion (DRG) neurons where it is believed to play an important role in nociception. Progress in revealing the functional properties and ... -
Functional Reconstitution of Human FcRn in Madin-Darby Canine Kidney Cells Requires Co-expressed Human β2-Microglobulin
(American Society for Biochemistry and Molecular Biology, 2002)The major histocompatibility complex class I-related neonatal Fc receptor, FcRn, assembles as a heterodimer consisting of a heavy chain and beta(2)-microglobulin (beta(2)m), which is essential for FcRn function. We observed ... -
Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1
(The Rockefeller University Press, 2014)The leucine zipper, EF hand–containing transmembrane protein 1 (Letm1) gene encodes a mitochondrial inner membrane protein, whose depletion severely perturbs mitochondrial Ca2+ and K+ homeostasis. Here we expressed, purified, ... -
Functional refolding of the penetration protein on a non-enveloped virus
(Springer Science and Business Media LLC, 2021-01-13)A non-enveloped virus requires a membrane lesion to deliver its genome into a target cell. For rotaviruses, membrane perforation is a principal function of the viral outer-layer protein, VP4. Here we describe the use of ... -
Functional role of the soluble guanylyl cyclase α1 subunit in vascular smooth muscle relaxation
(Oxford University Press (OUP), 2007)Objective: Soluble guanylyl cyclase (sGC), the predominant receptor for nitric oxide (NO), exists in 2 active isoforms (α2β1 and α1β1). In vascular tissue sGCα1β1 is believed to be the most important. The aim of our study ... -
Functional Roles of 10 Hz Alpha-Band Power Modulating Engagement and Disengagement of Cortical Networks in a Complex Visual Motion Task
(Public Library of Science, 2014)Alpha band power, particularly at the 10 Hz frequency, is significantly involved in sensory inhibition, attention modulation, and working memory. However, the interactions between cortical areas and their relationship to ... -
Functional screening identifies miR-315 as a potent activator of Wingless signaling
(Proceedings of the National Academy of Sciences, 2007-11-07)The existence of vast regulatory networks mediated by microRNAs (miRNAs) suggests broad potential for miRNA dysfunction to contrib- ute to disease. However, relatively few miRNA–target interactions are likely to make ... -
Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms
(Oxford University Press, 2014)Using a Drosophila model of Alzheimers disease (AD), we systematically evaluated 67 candidate genes based on AD-associated genomic loci (P 10(4)) from published human genome-wide association studies (GWAS). Genetic ... -
A Functional Selection Model Explains Evolutionary Robustness Despite Plasticity in Regulatory Networks
(Nature Publishing Group, 2012)Evolutionary rewiring of regulatory networks is an important source of diversity among species. Previous evidence suggested substantial divergence of regulatory networks across species. However, systematically assessing ... -
Functional SNPs in HSPA1A Gene Predict Risk of Coronary Heart Disease
(Public Library of Science, 2009)Background: HSP70 plays crucial roles in endothelial cell apoptosis, which is involved in the early phase and progress of coronary heart disease (CHD). However, the association between polymorphisms of HSP70 genes and the ... -
Functional Status Predicts Acute Care Readmissions from Inpatient Rehabilitation in the Stroke Population
(Public Library of Science, 2015)Objective: Acute care readmission risk is an increasingly recognized problem that has garnered significant attention, yet the reasons for acute care readmission in the inpatient rehabilitation population are complex and ... -
Functional Validation of an Alpha-Actinin-4 Mutation as a Potential Cause of an Aggressive Presentation of Adolescent Focal Segmental Glomerulosclerosis: Implications for Genetic Testing
(Public Library of Science, 2016)Genetic testing in the clinic and research lab is becoming more routinely used to identify rare genetic variants. However, attributing these rare variants as the cause of disease in an individual patient remains challenging. ...