Browsing Harvard Medical School by Title

Now showing items 6789-6808 of 18428

    • Future perspectives in melanoma research: meeting report from the “Melanoma Bridge”, Napoli, December 5th-8th 2013 

      Ascierto, Paolo A; Grimaldi, Antonio M; Anderson, Ana Carrizosa; Bifulco, Carlo; Cochran, Alistair; Garbe, Claus; Eggermont, Alexander M; Faries, Mark; Ferrone, Soldano; Gershenwald, Jeffrey E; Gajewski, Thomas F; Halaban, Ruth; Hodi, F Stephen; Kefford, Richard; Kirkwood, John M; Larkin, James; Leachman, Sancy; Maio, Michele; Marais, Richard; Masucci, Giuseppe; Melero, Ignacio; Palmieri, Giuseppe; Puzanov, Igor; Ribas, Antoni; Saenger, Yvonne; Schilling, Bastian; Seliger, Barbara; Stroncek, David; Sullivan, Ryan; Testori, Alessandro; Wang, Ena; Ciliberto, Gennaro; Mozzillo, Nicola; Marincola, Francesco M; Thurin, Magdalena (BioMed Central, 2014)
      The fourth “Melanoma Bridge Meeting” took place in Naples, December 5 to 8th, 2013. The four topics discussed at this meeting were: Diagnosis and New Procedures, Molecular Advances and Combination Therapies, News in ...

    • Future perspectives in melanoma research: Meeting report from the “Melanoma Bridge”. Napoli, December 1st–4th 2015 

      Ascierto, Paolo A.; Agarwala, Sanjiv; Botti, Gerardo; Cesano, Alessandra; Ciliberto, Gennaro; Davies, Michael A.; Demaria, Sandra; Dummer, Reinhard; Eggermont, Alexander M.; Ferrone, Soldano; Fu, Yang Xin; Gajewski, Thomas F.; Garbe, Claus; Huber, Veronica; Khleif, Samir; Krauthammer, Michael; Lo, Roger S.; Masucci, Giuseppe; Palmieri, Giuseppe; Postow, Michael; Puzanov, Igor; Silk, Ann; Spranger, Stefani; Stroncek, David F.; Tarhini, Ahmad; Taube, Janis M.; Testori, Alessandro; Wang, Ena; Wargo, Jennifer A.; Yee, Cassian; Zarour, Hassane; Zitvogel, Laurence; Fox, Bernard A.; Mozzillo, Nicola; Marincola, Francesco M.; Thurin, Magdalena (BioMed Central, 2016)
      The sixth “Melanoma Bridge Meeting” took place in Naples, Italy, December 1st–4th, 2015. The four sessions at this meeting were focused on: (1) molecular and immune advances; (2) combination therapies; (3) news in ...

    • Future perspectives in melanoma research: meeting report from the “Melanoma Bridge”: Napoli, December 3rd–6th 2014 

      Ascierto, Paolo A.; Atkins, Michael; Bifulco, Carlo; Botti, Gerardo; Cochran, Alistair; Davies, Michael; Demaria, Sandra; Dummer, Reinhard; Ferrone, Soldano; Formenti, Silvia; Gajewski, Thomas F.; Garbe, Claus; Khleif, Samir; Kiessling, Rolf; Lo, Roger; Lorigan, Paul; Arthur, Grant Mc; Masucci, Giuseppe; Melero, Ignacio; Mihm, Martin; Palmieri, Giuseppe; Parmiani, Giorgio; Puzanov, Igor; Romero, Pedro; Schilling, Bastian; Seliger, Barbara; Stroncek, David; Taube, Janis; Tomei, Sara; Zarour, Hassane M.; Testori, Alessandro; Wang, Ena; Galon, Jérôme; Ciliberto, Gennaro; Mozzillo, Nicola; Marincola, Francesco M.; Thurin, Magdalena (BioMed Central, 2015)
      The fourth “Melanoma Bridge Meeting” took place in Naples, December 3–6th, 2014. The four topics discussed at this meeting were: Molecular and Immunological Advances, Combination Therapies, News in Immunotherapy, and Tumor ...

    • Fuzzy Logic Analysis of Kinase Pathway Crosstalk in TNF/EGF/Insulin-Induced Signaling 

      Aldridge, Bree Beardsley; Saez-Rodriguez, Julio; Muhlich, Jeremy; Sorger, Peter Karl; Lauffenburger, Douglas A. (Public Library of Science, 2009)
      When modeling cell signaling networks, a balance must be struck between mechanistic detail and ease of interpretation. In this paper we apply a fuzzy logic framework to the analysis of a large, systematic dataset describing ...

    • Fuzzy Modeling to Predict Severely Depressed Left Ventricular Ejection Fraction following Admission to the Intensive Care Unit Using Clinical Physiology 

      Pereira, Rúben Duarte M. A.; Salgado, Cátia M.; Dejam, Andre; Reti, Shane R.; Vieira, Susana M.; Sousa, João M. C.; Celi, Leo A.; Finkelstein, Stan N. (Hindawi Publishing Corporation, 2015)
      Left ventricular ejection fraction (LVEF) constitutes an important physiological parameter for the assessment of cardiac function, particularly in the settings of coronary artery disease and heart failure. This study ...

    • The G-protein Alpha Subunit Gsα Is A Tumor Suppressor In Sonic Hedgehog-driven Medulloblastoma 

      He, Xuelian; Zhang, Liguo; Chen, Ying; Remke, Marc; Shih, David; Lu, Fanghui; Wang, Haibo; Deng, Yaqi; Yu, Yang; Xia, Yong; Wu, Xiaochong; Ramaswamy, Vijay; Hu, Tom; Wang, Fan; Zhou, Wenhao; Burns, Dennis K.; Kim, Se Hoon; Kool, Marcel; Pfister, Stefan M.; Weinstein, Lee S.; Pomeroy, Scott L.; Gilbertson, Richard J.; Rubin, Joshua B.; Hou, Yiping; Wechsler-Reya, Robert; Taylor, Michael D.; Lu, Q. Richard (2014)
      Medulloblastoma, the most common malignant childhood brain tumor, exhibits distinct molecular subtypes and cellular origins. Genetic alterations driving medulloblastoma initiation and progression remain poorly understood. ...

    • G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L 

      Zhang, Tao; Dong, Kangyun; Liang, Wei; Xu, Daichao; Xia, Hongguang; Geng, Jiefei; Najafov, Ayaz; Liu, Min; Li, Yanxia; Han, Xiaoran; Xiao, Juan; Jin, Zhenzhen; Peng, Ting; Gao, Yang; Cai, Yu; Qi, Chunting; Zhang, Qing; Sun, Anyang; Lipinski, Marta; Zhu, Hong; Xiong, Yue; Pandolfi, Pier Paolo; Li, He; Yu, Qiang; Yuan, Junying (eLife Sciences Publications, Ltd, 2015)
      Autophagy is an important intracellular catabolic mechanism involved in the removal of misfolded proteins. Atg14L, the mammalian ortholog of Atg14 in yeast and a critical regulator of autophagy, mediates the production ...

    • The G-protein–gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation 

      Mesirca, Pietro; Marger, Laurine; Toyoda, Futoshi; Rizzetto, Riccardo; Audoubert, Matthieu; Dubel, Stefan; Torrente, Angelo G.; DiFrancesco, Mattia L.; Muller, Jana Christina; Leoni, Anne-Laure; Couette, Brigitte; Nargeot, Joël; Clapham, David E.; Wickman, Kevin; Mangoni, Matteo E. (The Rockefeller University Press, 2013)
      Parasympathetic regulation of sinoatrial node (SAN) pacemaker activity modulates multiple ion channels to temper heart rate. The functional role of the G-protein–activated K+ current (IKACh) in the control of SAN pacemaking ...

    • G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments 

      Ivanov, Pavel; O’Day, Elizabeth; Emara, Mohamed M.; Wagner, Gerhard; Lieberman, Judy; Anderson, Paul (National Academy of Sciences, 2014)

    • G1 arrest and differentiation can occur independently of Rb family function 

      Wirt, S. E.; Adler, A. S.; Gebala, V.; Weimann, J. M.; Schaffer, B. E.; Saddic, L. A.; Viatour, P.; Vogel, H.; Chang, H. Y.; Meissner, Alexander; Sage, J. (Rockefeller University Press, 2010)
      The ability of progenitor cells to exit the cell cycle is essential for proper embryonic development and homeostasis, but the mechanisms governing cell cycle exit are still not fully understood. Here, we tested the requirement ...

    • G3BP–Caprin1–USP10 complexes mediate stress granule condensation and associate with 40S subunits 

      Kedersha, Nancy; Panas, Marc D.; Achorn, Christopher A.; Lyons, Shawn; Tisdale, Sarah; Hickman, Tyler; Thomas, Marshall; Lieberman, Judy; McInerney, Gerald M.; Ivanov, Pavel; Anderson, Paul (The Rockefeller University Press, 2016)
      Mammalian stress granules (SGs) contain stalled translation preinitiation complexes that are assembled into discrete granules by specific RNA-binding proteins such as G3BP. We now show that cells lacking both G3BP1 and ...

    • GABA\(_A\) Receptors Containing the \(\alpha\)2 Subunit Are Critical for Direction-Selective Inhibition in the Retina 

      Auferkorte, Olivia Nicola; Baden, Tom; Kaushalya, Sanjeev Kumar; Zabouri, Nawal; Rudolph, Uwe; Haverkamp, Silke; Euler, Thomas (Public Library of Science, 2012)
      Far from being a simple sensor, the retina actively participates in processing visual signals. One of the best understood aspects of this processing is the detection of motion direction. Direction-selective (DS) retinal ...

    • GABAA receptor signalling mechanisms revealed by structural pharmacology 

      Masiulis, Simonas; Desai, Rooma; Uchański, Tomasz; Serna Martin, Itziar; Laverty, Duncan; Karia, Dimple; Malinauskas, Tomas; Zivanov, Jasenko; Pardon, Els; Kotecha, Abhay; Steyaert, Jan; Miller, Keith; Aricescu, A. Radu (Springer Nature, 2019-01)
      Type-A -aminobutyric receptors (GABAARs) are ligand-gated chloride channels with a very rich pharmacology. Some of their modulators, including benzodiazepines and general anaesthetics, are among the most successful drugs ...

    • GABAergic parafacial zone is a medullary slow–wave–sleep promoting center 

      Anaclet, Christelle; Ferrari, Loris; Arrigoni, Elda; Bass, Caroline E.; Saper, Clifford B.; Lu, Jun; Fuller, Patrick M. (2014)
      Work in animals and humans suggest the existence of a slow–wave sleep (SWS) promoting/EEG synchronizing center in the mammalian lower brainstem. While sleep–active GABAergic neurons in the medullary parafacial zone (PZ) ...

    • GADD45α and γ interaction with CDK11p58 regulates SPDEF protein stability and SPDEF-mediated effects on cancer cell migration 

      Tamura, Rodrigo E.; Paccez, Juliano D.; Duncan, Kristal C.; Morale, Mirian G.; Simabuco, Fernando M.; Dillon, Simon; Correa, Ricardo G.; Gu, Xuesong; Libermann, Towia A.; Zerbini, Luiz F. (Impact Journals LLC, 2016)
      The epithelium-specific Ets transcription factor, SPDEF, plays a critical role in metastasis of prostate and breast cancer cells. While enhanced SPDEF expression blocks migration and invasion, knockdown of SPDEF expression ...

    • Gadolinium-Based Nanoparticles and Radiation Therapy for Multiple Brain Melanoma Metastases: Proof of Concept before Phase I Trial 

      Kotb, Shady; Detappe, Alexandre; Lux, François; Appaix, Florence; Barbier, Emmanuel L.; Tran, Vu-Long; Plissonneau, Marie; Gehan, Hélène; Lefranc, Florence; Rodriguez-Lafrasse, Claire; Verry, Camille; Berbeco, Ross; Tillement, Olivier; Sancey, Lucie (Ivyspring International Publisher, 2016)
      Nanoparticles containing high-Z elements are known to boost the efficacy of radiation therapy. Gadolinium (Gd) is particularly attractive because this element is also a positive contrast agent for MRI, which allows for the ...

    • GagPol-specific CD4+ T-cells increase the antibody response to Env by intrastructural help 

      Nabi, Ghulam; Genannt Bonsmann, Michael Storcksdieck; Tenbusch, Matthias; Gardt, Oliver; Barouch, Dan H; Temchura, Vladimir; Überla, Klaus (BioMed Central, 2013)
      Background: Immunization of rhesus macaques against Gag of SIV resulted in a more rapid appearance of Env antibodies after infection with SIV or SHIV challenge viruses although the vaccines lacked an Env component. We ...

    • Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling 

      Rice, Gillian I; del Toro Duany, Yoandris; Jenkinson, Emma M; Forte, Gabriella MA; Anderson, Beverley H; Ariaudo, Giada; Bader-Meunier, Brigitte; Baildam, Eileen M; Battini, Roberta; Beresford, Michael W; Casarano, Manuela; Chouchane, Mondher; Cimaz, Rolando; Collins, Abigail E; Cordeiro, Nuno JV; Dale, Russell C; Davidson, Joyce E; De Waele, Liesbeth; Desguerre, Isabelle; Faivre, Laurence; Fazzi, Elisa; Isidor, Bertrand; Lagae, Lieven; Latchman, Andrew R; Lebon, Pierre; Li, Chumei; Livingston, John H; Lourenço, Charles M; Mancardi, Maria Margherita; Masurel-Paulet, Alice; McInnes, Iain B; Menezes, Manoj P; Mignot, Cyril; O’Sullivan, James; Orcesi, Simona; Picco, Paolo P; Riva, Enrica; Robinson, Robert A; Rodriguez, Diana; Salvatici, Elisabetta; Scott, Christiaan; Szybowska, Marta; Tolmie, John L; Vanderver, Adeline; Vanhulle, Catherine; Vieira, Jose Pedro; Webb, Kate; Whitney, Robyn N; Williams, Simon G; Wolfe, Lynne A; Zuberi, Sameer M; Hur, Sun; Crow, Yanick J (2014)
      The type I interferon system is integral to human antiviral immunity. However, inappropriate stimulation or defective negative regulation of this system can lead to inflammatory disease. We sought to determine the molecular ...

    • Gain-of-Sensitivity Mutations in a Trim5-Resistant Primary Isolate of Pathogenic SIV Identify Two Independent Conserved Determinants of Trim5α Specificity 

      McCarthy, Kevin Raymond; Schmidt, Aaron Gregory; Kirmaier, Andrea; Wyand, Allison L.; Newman, Ruchi M.; Johnson, Welkin E. (Public Library of Science, 2013)
      Retroviral capsid recognition by Trim5 blocks productive infection. Rhesus macaques harbor three functionally distinct Trim5 alleles: Trim5αQ, Trim5αTFP and Trim5CypA. Despite the high degree of amino acid identity between ...

    • Gaining the hard yard: pre-clinical evaluation of lentiviral-mediated gene therapy for the treatment of β-thalassemia 

      Milsom, Michael D; Williams, David Allan (WILEY-VCH Verlag, 2010)
      Gene therapy is one potential novel therapeutic avenue for the treatment of inherited monogenic disorders. Diseases of the blood are frequent targets for gene therapy because it is relatively easy to harvest haematopoietic ...