Browsing Harvard Medical School by Title

Now showing items 6861-6880 of 18426

    • Gender and vocal production mode discrimination using the high frequencies for speech and singing 

      Monson, Brian B.; Lotto, Andrew J.; Story, Brad H. (Frontiers Media S.A., 2014)
      Humans routinely produce acoustical energy at frequencies above 6 kHz during vocalization, but this frequency range is often not represented in communication devices and speech perception research. Recent advancements ...

    • Gender difference in motor impairments induced by chronic administration of vinblastine 

      Parsania, Shahrnaz; Shabani, Mohammad; Moazzami, Kasra; Razavinasab, Moazamehosadat; Larizadeh, Mohammad Hassan; Nazeri, Masoud; Asadi-Shekaari, Majid; Kermani, Moein (Mashhad University of Medical Sciences, 2014)
      Objective(s): Neurotoxicity of anticancer drugs complicates treatment of cancer patients. Vinblastine (VBL) is reported to induce motor and cognitive impairments in patients receiving chronic low-dose regimen. Materials ...

    • Gender Differences in Left Ventricular Geometry and Determinants of Myocardial Perfusion Reserve in Patients with Severe Aortic Stenosis 

      Steadman, Christopher D; Jerosch-Herold, Michael; Grundy, Benjamin; Rafelt, Suzanne; Ng, Leong L; Squire, Iain B; Samani, Nilesh J; McCann, Gerry P (BioMed Central, 2011)

    • Gender Differences in Real-Home Sleep of Young and Older Couples 

      Butt, Maryam; Quan, Stuart Fun; Pentland, Alex (Sandy); Khaya, Inas (Southwest Journal of Pulmonary and Critical Care, 2015)
      Objectives: To understand gender differences in sleep quality, architecture and duration of young healthy couples in comparison to older couples in their natural sleep environment. Design: Sleep was monitored in a naturalistic ...

    • Gender Differences in Somatic Symptoms and Current Suicidal Risk in Outpatients with Major Depressive Disorder 

      Jeon, Hong Jin; Woo, Jong-Min; Kim, Hyo-Jin; Fava, Maurizio; Mischoulon, David; Cho, Seong Jin; Chang, Sung Man; Park, Doo-Heum; Kim, Jong Woo; Yoo, Ikki; Heo, Jung-Yoon; Hong, Jin Pyo (Korean Neuropsychiatric Association, 2016)
      Objective: Although somatic symptoms are common complaints of patients with major depressive disorder (MDD), their associations with suicide are still unclear. Methods: A total of 811 MDD outpatients of aged between 18 to ...

    • Gender Differences in Sustained Attentional Control Relate to Gender Inequality across Countries 

      Riley, Elizabeth; Okabe, Hidefusa; Germine, Laura; Wilmer, Jeremy; Esterman, Michael; DeGutis, Joseph (Public Library of Science, 2016)
      Sustained attentional control is critical for everyday tasks and success in school and employment. Understanding gender differences in sustained attentional control, and their potential sources, is an important goal of ...

    • Gender Differences in the Motivational Processing of Babies Are Determined by Their Facial Attractiveness 

      Yamamoto, Rinah Tikvah; Ariely, Dan; Chi, Won; Langleben, Daniel D.; Elman, Igor (Public Library of Science, 2009)
      Background: This study sought to determine how esthetic appearance of babies may affect their motivational processing by the adults. Methodology and Principal Findings: Healthy men and women were administered two ...

    • Gender Disparity and Mutation Burden in Melanoma 

      Gupta, Sameer (2016-05-17)
      A female advantage in melanoma incidence and outcome has been consistently observed but remains unexplained. We hypothesized that tumors are genetically distinct between men and women and analyzed the mutation spectra in ...

    • Gender-Related Differences in the Prevalence of Cardiovascular Disease Risk Factors and their Correlates in Urban Tanzania 

      Njelekela, Marina A; Mpembeni, Rose; Mligiliche, Nuru L; Mtabaji, Jacob; Muhihi, Alfa; Spiegelman, Donna Lynn; Hertzmark, Ellen; Liu, Enju; Finkelstein, Julia Leigh; Fawzi, Wafaie W.; Willett, Walter C. (BioMed Central, 2009)
      Background: Urban areas in Africa suffer a serious problem with dual burden of infectious diseases and emerging chronic diseases such as cardiovascular diseases (CVD) and diabetes which pose a serious threat to population ...

    • Gender-specific hypertension and responsiveness to nitric oxide in sGCa1 knockout mice 

      Buys, Emmanuel; Sips, Patrick; Vermeersch, Pieter; Raher, Michael J.; Rogge, Elke; Ichinose, Fumito; Dewerchin, Mieke; Bloch, Kenneth; Janssens, Stefan; Brouckaert, Peter (Oxford University Press (OUP), 2008)
      Aim: The effects of nitric oxide (NO) in the cardiovascular system are attributed in part to cGMP synthesis by the α1β1 isoform of soluble guanylate cyclase (sGC). Because available sGC inhibitors are neither enzyme- nor ...

    • Gender-Specific Modulation of the Response to Arterial Injury by Soluble Guanylate Cyclase α1 

      Vermeersch, Pieter; Pokreisz, Peter; Marsboom, Glenn; Gillijns, Hilde; Pellens, Marijke; Dewerchin, Mieke; Brouckaert, Peter; Janssens, Stefan; Buys, Emmanuel; Sips, Patrick; Bloch, Kenneth Daniel (Bentham Open, 2009)
      Objective: Soluble guanylate cyclase (sGC), a heterodimer composed of α and β subunits, synthesizes cGMP in response to nitric oxide (NO). NO modulates vascular tone and structure but the relative contributions of ...

    • Gender-Specific Molecular and Clinical Features Underlie Malignant Pleural Mesothelioma 

      De Rienzo, Assunta; Archer, Michael A.; Yeap, Beow; Dao, Nhien; Sciaranghella, Daniele; Sideris, Antonios C.; Zheng, Yifan; Holman, Alexander G.; Wang, Yaoyu E.; Dal Cin, Paola; Fletcher, Jonathan; Rubio, Renee; Croft, Larry; Quackenbush, John; Sugarbaker, Peter E.; Munir, Kiara J.; Battilana, Jesse R.; Gustafson, Corinne; Chirieac, Lucian; Ching, Soo Meng; Wong, James; Tay, Liang Chung; Rudd, Stephen; Hercus, Robert; Sugarbaker, David J.; Richards, William; Bueno, Raphael (American Association for Cancer Research (AACR), 2016-01-15)
      Malignant pleural mesothelioma (MPM) is an aggressive cancer that occurs more frequently in men, but is associated with longer survival in women. Insight into the survival advantage of female patients may advance the ...

    • Gene 1.7 of bacteriophage T7 confers sensitivity of phage growth to dideoxythymidine 

      Tran, Ngoc Q.; Rezende, Lisa F.; Qimron, Udi; Richardson, Charles C.; Tabor, Stanley (National Academy of Sciences, 2008)
      Bacteriophage T7 DNA polymerase efficiently incorporates dideoxynucleotides into DNA, resulting in chain termination. Dideoxythymidine (ddT) present in the medium at levels not toxic to Escherichia coli inhibits phage T7. ...

    • Gene 4 DNA Primase of Bacteriophage T7 Mediates the Annealing and Extension of Ribo-oligonucleotides at Primase Recognition Sites 

      Kusakabe, Takahiro; Richardson, Charles C. (American Society for Biochemistry and Molecular Biology, 1997)
      The 63-kDa gene 4 primase of bacteriophage T7 recognizes a core trinucleotide sequence, 5'-GTC-3', on single-stranded DNA at which it catalyzes the synthesis of the ribodinucleotide pppAC. The dinucleotide is extended to ...

    • Gene 5.5 protein of bacteriophage T7 in complex with Escherichia coli nucleoid protein H-NS and transfer RNA masks transfer RNA priming in T7 DNA replication 

      Zhu, Bin; Lee, Seung-Joo; Tan, Min; Wang, En-Duo; Richardson, Charles C. (National Academy of Sciences, 2012)
      DNA primases provide oligoribonucleotides for DNA polymerase to initiate lagging strand synthesis. A deficiency in the primase of bacteriophage T7 to synthesize primers can be overcome by genetic alterations that decrease ...

    • Gene and Genome Parameters of Mammalian Liver Circadian Genes (LCGs) 

      Wu, Gang; Zhu, Jiang; He, Fuhong; Wang, Weiwei; Hu, Songnian; Yu, Jun (Public Library of Science, 2012)
      The mammalian circadian system controls various physiology processes and behavior responses by regulating thousands of circadian genes with rhythmic expressions. In this study, we redefined circadian-regulated genes based ...

    • Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas 

      Eising, Else; Huisman, Sjoerd M. H.; Mahfouz, Ahmed; Vijfhuizen, Lisanne S.; Anttila, Verneri; Winsvold, Bendik S.; Kurth, Tobias; Ikram, M. Arfan; Freilinger, Tobias; Kaprio, Jaakko; Boomsma, Dorret I.; van Duijn, Cornelia M.; Järvelin, Marjo-Riitta R.; Zwart, John-Anker; Quaye, Lydia; Strachan, David P.; Kubisch, Christian; Dichgans, Martin; Davey Smith, George; Stefansson, Kari; Palotie, Aarno; Chasman, Daniel I.; Ferrari, Michel D.; Terwindt, Gisela M.; de Vries, Boukje; Nyholt, Dale R.; Lelieveldt, Boudewijn P. F.; van den Maagdenberg, Arn M. J. M.; Reinders, Marcel J. T. (Springer Berlin Heidelberg, 2016)
      Migraine is a common disabling neurovascular brain disorder typically characterised by attacks of severe headache and associated with autonomic and neurological symptoms. Migraine is caused by an interplay of genetic and ...

    • Gene Editing Using CRISPR 

      Komaroff, Anthony L. (American Medical Association (AMA), 2017)
      The gene-editing technique known as CRISPR (clustered regularly interspaced short palindromic repeats) is only 5 years old, yet it has galvanized biomedical research and raised important ethical questions. What is it, how ...

    • Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures 

      Prilutsky, Daria; Kho, Alvin T.; Palmer, Nathan P.; Bhakar, Asha L.; Smedemark-Margulies, Niklas; Margulies, David M.; Kong, Sek Won; Bear, Mark F.; Kohane, Isaac S. (BioMed Central, 2015)
      Background: Fragile X syndrome (FXS) is a neurodevelopmental disorder whose biochemical manifestations involve dysregulation of mGluR5-dependent pathways, which are widely modeled using cultured neurons. In vitro phenotypes ...

    • Gene Expression Analysis of Embryonic Stem Cells Expressing VE-Cadherin (CD144) During Endothelial Differentiation 

      Nikolova-Krstevski, Vesna; Bhasin, Manoj; Otu, Hasan H; Libermann, Towia Aron; Oettgen, Peter (BioMed Central, 2008)
      Backgroun: Endothelial differentiation occurs during normal vascular development in the developing embryo. This process is recapitulated in the adult when endothelial progenitor cells are generated in the bone marrow and ...