Browsing Harvard Medical School by Title
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Gene Expression Analysis of Zebrafish Heart Regeneration
(Public Library of Science, 2006)Mammalian hearts cannot regenerate. In contrast, zebrafish hearts regenerate even when up to 20% of the ventricle is amputated. The mechanism of zebrafish heart regeneration is not understood. To systematically characterize ... -
Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells
(Elsevier BV, 2013)Hedgehog Interacting Protein (HHIP) was implicated in chronic obstructive pulmonary disease (COPD) by genome-wide association studies (GWAS). However, it remains unclear how HHIP contributes to COPD pathogenesis. To identify ... -
Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex
(Nature Publishing Group, 2006)Two key models for examining activity-dependent development of primary visual cortex (V1) involve either reduction of activity in both eyes via dark-rearing (DR) or imbalance of activity between the two eyes via monocular ... -
Gene Expression Changes within Müller Glial Cells in Retinitis Pigmentosa
(Molecular Vision, 2012)Purpose: Retinitis pigmentosa (RP) is a progressive retinal degeneration in which the retina loses nearly all of its photoreceptor cells and undergoes major structural changes. Little is known regarding the role the resident ... -
Gene expression defines natural changes in mammalian lifespan
(BlackWell Publishing Ltd, 2015)Mammals differ more than 100-fold in maximum lifespan, which can be altered in either direction during evolution, but the molecular basis for natural changes in longevity is not understood. Divergent evolution of mammals ... -
Gene Expression during the Generation and Activation of Mouse Neutrophils: Implication of Novel Functional and Regulatory Pathways
(Public Library of Science, 2014)As part of the Immunological Genome Project (ImmGen), gene expression was determined in unstimulated (circulating) mouse neutrophils and three populations of neutrophils activated in vivo, with comparison among these ... -
A Gene Expression Fingerprint of C. elegans Embryonic Motor Neurons
(BioMed Central, 2005)Background: Differential gene expression specifies the highly diverse cell types that constitute the nervous system. With its sequenced genome and simple, well-defined neuroanatomy, the nematode C. elegans is a useful model ... -
The Gene Expression Grade Index: A Potential Predictor of Relapse for Endocrine-treated Breast Cancer Patients in the BIG 1–98 Trial
(BioMed Central, 2009)Background: We have previously shown that the Gene expression Grade Index (GGI) was able to identify two subtypes of estrogen receptor (ER)-positive tumors that were associated with statistically distinct clinical outcomes ... -
Gene expression network analyses in response to air pollution exposures in the trucking industry
(BioMed Central, 2016)Background: Exposure to air pollution, including traffic-related pollutants, has been associated with a variety of adverse health outcomes, including increased cardiopulmonary morbidity and mortality, and increased lung ... -
Gene expression of the IGF pathway family distinguishes subsets of gastrointestinal stromal tumors wild type for KIT and PDGFRA
(Blackwell Publishing Ltd, 2013)Gastrointestinal stromal tumors (GISTs) arise from the interstitial cells of Cajal (ICCs) and are the most common mesenchymal neoplasm of the gastrointestinal tract. While the majority of GISTs harbor activating mutations ... -
Gene expression prediction using low-rank matrix completion
(BioMed Central, 2016)Background: An exponential growth of high-throughput biological information and data has occurred in the past decade, supported by technologies, such as microarrays and RNA-Seq. Most data generated using such methods are ... -
Gene Expression Profile Alone Is Inadequate In Predicting Complete Response In Multiple Myeloma
(2014)With advent of several treatment options in multiple myeloma, a selection of effective regimen has become an important issue. Use of GEP is considered an important tool in predicting outcome; however, it is unclear whether ... -
A Gene Expression Profile of Stem Cell Pluripotentiality and Differentiation Is Conserved across Diverse Solid and Hematopoietic Cancers
(BioMed Central, 2012)Background: Understanding the fundamental mechanisms of tumorigenesis remains one of the most pressing problems in modern biology. To this end, stem-like cells with tumor-initiating potential have become a central focus ... -
Gene expression profile testing for breast cancer and the use of chemotherapy, serious adverse effects, and costs of care
(Springer Science + Business Media, 2011)As gene expression profile (GEP) testing for breast cancer may provide additional prognostic information to guide the use of adjuvant chemotherapy, we examined the association between GEP testing and use of chemotherapy, ... -
Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes
(Public Library of Science, 2010)Background: Changes in gene expression in pancreatic beta-cells from type 2 diabetes (T2D) should provide insights into their abnormal insulin secretion and turnover. Methodology/Principal Findings: Frozen sections were ... -
Gene Expression Profiling of Human Vaginal Cells In Vitro Discriminates Compounds with Pro-Inflammatory and Mucosa-Altering Properties: Novel Biomarkers for Preclinical Testing of HIV Microbicide Candidates
(Public Library of Science, 2015)Background: Inflammation and immune activation of the cervicovaginal mucosa are considered factors that increase susceptibility to HIV infection. Therefore, it is essential to screen candidate anti-HIV microbicides for ... -
Gene Expression Signature of Normal Cell-of-Origin Predicts Ovarian Tumor Outcomes
(Public Library of Science, 2013)The potential role of the cell-of-origin in determining the tumor phenotype has been raised, but not adequately examined. We hypothesized that distinct cells-of-origin may play a role in determining ovarian tumor phenotype ... -
Gene Expression-Based Screening for Inhibitors of PDGFR Signaling
(BioMed Central, 2008)Here we describe a proof-of-concept experiment designed to explore the possibility of using gene expression-based high-throughput screening (GE-HTS) to find inhibitors of a signaling cascade, using platelet derived growth ... -
Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1α and oxidative phosphorylation
(National Academy of Sciences, 2008) -
Gene Network Analysis of Bone Marrow Mononuclear Cells Reveals Activation of Multiple Kinase Pathways in Human Systemic Lupus Erythematosus
(Public Library of Science, 2010)Background: Gene profiling studies provide important information for key molecules relevant to a disease but are less informative of protein-protein interactions, post-translational modifications and regulation by targeted ...