Browsing Harvard Medical School by Title
Now showing items 7555-7574 of 18428
-
Harsh discipline relates to internalizing problems and cognitive functioning: findings from a cross-sectional study with school children in Tanzania
(BioMed Central, 2016)Background: Child maltreatment poses a risk to children and adolescents’ mental health and may also affect cognitive functioning. Also harsh discipline has been frequently associated with mental health problems. However, ... -
The Harvard Beat Assessment Test (H-BAT): a battery for assessing beat perception and production and their dissociation
(Frontiers Media S.A., 2013)Humans have the abilities to perceive, produce, and synchronize with a musical beat, yet there are widespread individual differences. To investigate these abilities and to determine if a dissociation between beat perception ... -
Harvard Personal Genome Project: lessons from participatory public research
(BioMed Central, 2014)Background: Since its initiation in 2005, the Harvard Personal Genome Project has enrolled thousands of volunteers interested in publicly sharing their genome, health and trait data. Because these data are highly identifiable, ... -
Has the DOTS Strategy Improved Case Finding or Treatment Success? An Empirical Assessment
(Public Library of Science, 2008)Background: Nearly fifteen years after the start of WHO's DOTS strategy, tuberculosis remains a major global health problem. Given the lack of empirical evidence that DOTS reduces tuberculosis burden, considerable debate ... -
Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation
(The Rockefeller University Press, 2012)Haspin phosphorylates histone H3 at threonine-3 (H3T3ph), providing a docking site for the Aurora B complex at centromeres. Aurora B functions to correct improper kinetochore–microtubule attachments and alert the spindle ... -
Hazards of Hindsight — Monitoring the Safety of Nutritional Supplements
(New England Journal of Medicine (NEJM/MMS), 2014) -
HbA1c After a Short Period of Monotherapy With Metformin Identifies Durable Glycemic Control Among Adolescents With Type 2 Diabetes
(American Diabetes Association, 2015)OBJECTIVE To determine whether clinically accessible parameters early in the course of youth-onset type 2 diabetes predict likelihood of durable control on oral therapy. RESEARCH DESIGN AND METHODS TODAY was a randomized ... -
HbA\(_{1c}\) Levels in Schoolchildren With Type 1 Diabetes Are Seasonally Variable and Dependent on Weather Conditions
(Springer-Verlag, 2010)Aims/hypothesis: We evaluated seasonal HbA\(_{1c}\) changes in children with type 1 diabetes and its relation with measures of weather conditions. Methods: HbA\(_{1c}\) changes over more than 3 years were evaluated in type ... -
HCO3−/Cl− Exchange Inactivation and Reactivation during Mouse Oocyte Meiosis Correlates with MEK/MAPK-Regulated Ae2 Plasma Membrane Localization
(Public Library of Science, 2009)Background: Germinal Vesicle (GV) stage mouse oocytes in first meiotic prophase exhibit highly active HCO3−/Cl− exchange—a class of transport nearly ubiquitously involved in regulation of intracellular pH and cell volume. ... -
HCV induces transforming growth factor β1 through activation of endoplasmic reticulum stress and the unfolded protein response
(Nature Publishing Group, 2016)HCV replication disrupts normal endoplasmic reticulum (ER) function and activates a signaling network called the unfolded protein response (UPR). UPR is directed by three ER transmembrane proteins including ATF6, IRE1, and ... -
HD CAGnome: A Search Tool for Huntingtin CAG Repeat Length-Correlated Genes
(Public Library of Science, 2014)Background: The length of the huntingtin (HTT) CAG repeat is strongly correlated with both age at onset of Huntington’s disease (HD) symptoms and age at death of HD patients. Dichotomous analysis comparing HD to controls ... -
The HDAC Inhibitors Scriptaid and LBH589 Combined with the Oncolytic Virus Delta24-RGD Exert Enhanced Anti-Tumor Efficacy in Patient-Derived Glioblastoma Cells
(Public Library of Science, 2015)Background: A phase I/II trial for glioblastoma with the oncolytic adenovirus Delta24-RGD was recently completed. Delta24-RGD conditionally replicates in cells with a disrupted retinoblastoma-pathway and enters cells via ... -
HDAC2 Negatively Regulates Memory Formation and Synaptic Plasticity
(Nature Publishing Group, 2012)Chromatin modifications, especially histone-tail acetylation, have been implicated in memory formation. Increased histone-tail acetylation induced by inhibitors of histone deacetylases (HDACis) facilitates learning and ... -
HDAC3 regulates DNMT1 expression in multiple myeloma: therapeutic implications
(Springer Science and Business Media LLC, 2017-05-11)Epigenetic signaling pathways are implicated in tumorigenesis and therefore histone deacetylases (HDACs) represent novel therapeutic targets for cancers, including multiple myeloma (MM). Although non-selective HDAC inhibitors ... -
HDAC6 Inhibitors Modulate Lys49 Acetylation and Membrane Localization of β-Catenin in Human iPSC-Derived Neuronal Cells
(American Chemical Society, 2014)We examined the effects of isoform-specific histone deacetylase (HDAC) inhibitors on β-catenin posttranslational modifications in neural progenitor cells (NPCs) derived from human induced pluripotent stem cells (iPSCs). ... -
HDACi inhibits liposarcoma via targeting of the MDM2-p53 signaling axis and PTEN, irrespective of p53 mutational status
(Impact Journals LLC, 2015)The MDM2-p53 pathway plays a prominent role in well-differentiated liposarcoma (LPS) pathogenesis. Here, we explore the importance of MDM2 amplification and p53 mutation in LPS independently, to determine whether HDACi are ... -
HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation
(Public Library of Science, 2015)The HTT CAG expansion mutation causes Huntington’s Disease and is associated with a wide range of cellular consequences, including altered metabolism. The mutant allele is expressed widely, in all tissues, but the striatum ... -
HE4 (WFDC2) Promotes Tumor Growth in Endometrial Cancer Cell Lines
(Molecular Diversity Preservation International (MDPI), 2013)HE4, also known as WFDC2, is a useful biomarker for ovarian cancer when either used alone or in combination with CA125. HE4 is also overexpressed in endometrial cancer (EC), but its function in cancer cells is not clear. ... -
Head Circumference as a Useful Surrogate for Intracranial Volume in Older Adults
(Cambridge University Press (CUP), 2016-01)Background Intracranial volume (ICV) has been proposed as a measure of maximum lifetime brain size. Accurate ICV measures require neuroimaging which is not always feasible for epidemiologic investigations. We examined ... -
Head CT is of Limited Diagnostic Value in Critically Ill Patients Who Remain Unresponsive After Discontinuation of Sedation
(BioMed Central, 2009)Background: Prolonged sedation is common in mechanically ventilated patients and is associated with increased morbidity and mortality. We sought to determine the diagnostic value of head computed tomography (CT) in ...