Browsing Harvard Medical School by Title

Now showing items 8303-8322 of 18428

    • Identification of novel antimicrobials using a live-animal infection model 

      Moy, Terence I.; Ball, Anthony R.; Anklesaria, Zafia; Casadei, Gabriele; Lewis, Kim; Ausubel, Frederick M. (National Academy of Sciences, 2006)
      The alarming increase of antibiotic-resistant bacterial pathogens points to the need for novel therapeutic approaches to combat infection. To discover novel antimicrobials, we devised a screen to identify compounds that ...

    • Identification of Novel Genetic Markers of Breast Cancer Survival 

      Guo, Qi; Schmidt, Marjanka K.; Kraft, Peter; Canisius, Sander; Chen, Constance; Khan, Sofia; Tyrer, Jonathan; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Michailidou, Kyriaki; Lush, Michael; Kar, Siddhartha; Beesley, Jonathan; Dunning, Alison M.; Shah, Mitul; Czene, Kamila; Darabi, Hatef; Eriksson, Mikael; Lambrechts, Diether; Weltens, Caroline; Leunen, Karin; Bojesen, Stig E.; Nordestgaard, Børge G.; Nielsen, Sune F.; Flyger, Henrik; Chang-Claude, Jenny; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Blomqvist, Carl; Aittomäki, Kristiina; Fagerholm, Rainer; Muranen, Taru A.; Couch, Fergus J.; Olson, Janet E.; Vachon, Celine; Andrulis, Irene L.; Knight, Julia A.; Glendon, Gord; Mulligan, Anna Marie; Broeks, Annegien; Hogervorst, Frans B.; Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Fredrick; Le Marchand, Loic; Hopper, John L.; Tsimiklis, Helen; Apicella, Carmel; Southey, Melissa C.; Cox, Angela; Cross, Simon S.; Reed, Malcolm W. R.; Giles, Graham G.; Milne, Roger L.; McLean, Catriona; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Hooning, Maartje J.; Hollestelle, Antoinette; Martens, John W. M.; van den Ouweland, Ans M. W.; Marme, Federik; Schneeweiss, Andreas; Yang, Rongxi; Burwinkel, Barbara; Figueroa, Jonine; Chanock, Stephen J.; Lissowska, Jolanta; Sawyer, Elinor J.; Tomlinson, Ian; Kerin, Michael J.; Miller, Nicola; Brenner, Hermann; Dieffenbach, Aida Karina; Arndt, Volker; Holleczek, Bernd; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M.; Li, Jingmei; Brand, Judith S.; Humphreys, Keith; Devilee, Peter; Tollenaar, Rob A. E. M.; Seynaeve, Caroline; Radice, Paolo; Peterlongo, Paolo; Bonanni, Bernardo; Mariani, Paolo; Fasching, Peter A.; Beckmann, Matthias W.; Hein, Alexander; Ekici, Arif B.; Chenevix-Trench, Georgia; Balleine, Rosemary; Phillips, Kelly-Anne; Benitez, Javier; Zamora, M. Pilar; Arias Perez, Jose Ignacio; Menéndez, Primitiva; Jakubowska, Anna; Lubinski, Jan; Jaworska-Bieniek, Katarzyna; Durda, Katarzyna; Hamann, Ute; Kabisch, Maria; Ulmer, Hans Ulrich; Rüdiger, Thomas; Margolin, Sara; Kristensen, Vessela; Nord, Silje; Evans, D. Gareth; Abraham, Jean E.; Earl, Helena M.; Hiller, Louise; Dunn, Janet A.; Bowden, Sarah; Berg, Christine; Campa, Daniele; Diver, W. Ryan; Gapstur, Susan M.; Gaudet, Mia M.; Hankinson, Susan E.; Hoover, Robert N.; Hüsing, Anika; Kaaks, Rudolf; Machiela, Mitchell J.; Willett, Walter; Barrdahl, Myrto; Canzian, Federico; Chin, Suet-Feung; Caldas, Carlos; Hunter, David J.; Lindstrom, Sara; García-Closas, Montserrat; Hall, Per; Easton, Douglas F.; Eccles, Diana M.; Rahman, Nazneen; Nevanlinna, Heli; Pharoah, Paul D. P. (Oxford University Press, 2015)
      Background: Survival after a diagnosis of breast cancer varies considerably between patients, and some of this variation may be because of germline genetic variation. We aimed to identify genetic markers associated with ...

    • Identification of Novel Glial Genes by Single-Cell Transcriptional Profiling of Bergmann Glial Cells from Mouse Cerebellum 

      Koirala, Samir; Corfas, Gabriel (Public Library of Science, 2010)
      Bergmann glial cells play critical roles in the structure and function of the cerebellum. During development, their radial processes serve as guides for migrating granule neurons and their terminal endfeet tile to form the ...

    • Identification of Novel Imprinted Differentially Methylated Regions by Global Analysis of Human-Parthenogenetic-Induced Pluripotent Stem Cells 

      Stelzer, Yonatan; Ronen, Daniel; Bock, Christoph; Boyle, Patrick; Meissner, Alexander; Benvenisty, Nissim (Elsevier, 2013)
      Parental imprinting is an epigenetic phenomenon by which genes are expressed in a monoallelic fashion, according to their parent of origin. DNA methylation is considered the hallmark mechanism regulating parental imprinting. ...

    • Identification of novel lncRNAs regulated by the TAL1 complex in T-cell acute lymphoblastic leukemia 

      Ngoc, Phuong Cao Thi; Tan, Shi Hao; Tan, Tze King; Chan, Min Min; Li, Zhenhua; Yeoh, Allen. E. J.; Tenen, Daniel; Sanda, Takaomi (Springer Science and Business Media LLC, 2018-03-26)
      TAL1/SCL is one of the most prevalent oncogenes in T-cell acute lymphoblastic leukemia (T-ALL). TAL1 and its regulatory partners (GATA3, RUNX1, and MYB) positively regulate each other and coordinately regulate the expression ...

    • Identification of novel myeloma-specific XBP1 peptides able to generate cytotoxic T lymphocytes: A potential therapeutic application in multiple myeloma 

      Bae, Jooeun; Carrasco, Ruben D.; Lee, Ann-Hwee; Tai, Yu-Tzu; Anderson, Kenneth Carl; Munshi, Nikhil C. (2012)
      The purpose of these studies was to identify HLA-A2+ immunogenic peptides derived from XBP1 antigens to induce a multiple myeloma (MM)-specific immune response. Six native peptides from non-spliced XBP1 antigen and three ...

    • Identification of Novel Non-Coding Small RNAs from Streptococcus Pneumoniae TIGR4 Using High-Resolution Genome Tiling Arrays 

      Kumar, Ranjit; Shah, Pratik; Swiatlo, Edwin; Burgess, Shane C; Lawrence, Mark L; Nanduri, Bindu (BioMed Central, 2010)
      Background: The identification of non-coding transcripts in human, mouse, and Escherichia coli has revealed their widespread occurrence and functional importance in both eukaryotic and prokaryotic life. In prokaryotes, ...

    • Identification of Novel Pro-Migratory, Cancer-Associated Genes Using Quantitative, Microscopy-Based Screening 

      Naffar-Abu-Amara, Suha; Shay, Tal; Galun, Meirav; Cohen, Naomi; Isakoff, Steven Jay; Kam, Zvi; Geiger, Benjamin (Public Library of Science, 2008)
      Background: Cell migration is a highly complex process, regulated by multiple genes, signaling pathways and external stimuli. To discover genes or pharmacological agents that can modulate the migratory activity of cells, ...

    • Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase 

      Moccia, Marialuisa; Liu, Qingsong; Guida, Teresa; Federico, Giorgia; Brescia, Annalisa; Zhao, Zheng; Choi, Hwan Geun; Deng, Xianming; Tan, Li; Wang, Jinhua; Billaud, Marc; Gray, Nathanael S.; Carlomagno, Francesca; Santoro, Massimo (Public Library of Science, 2015)
      Oncogenic mutation of the RET receptor tyrosine kinase is observed in several human malignancies. Here, we describe three novel type II RET tyrosine kinase inhibitors (TKI), ALW-II-41-27, XMD15-44 and HG-6-63-01, that ...

    • Identification of Novel sRNAs in Mycobacterial Species 

      Tsai, Chen-Hsun; Baranowski, Catherine; Livny, Jonathan; McDonough, Kathleen A.; Wade, Joseph T.; Contreras, Lydia M. (Public Library of Science, 2013)
      Bacterial small RNAs (sRNAs) are short transcripts that typically do not encode proteins and often act as regulators of gene expression through a variety of mechanisms. Regulatory sRNAs have been identified in many species, ...

    • Identification of Novel Type 2 Diabetes Candidate Genes Involved in the Crosstalk between the Mitochondrial and the Insulin Signaling Systems 

      Mercader, Josep M.; Puiggros, Montserrat; Segrè, Ayellet V.; Planet, Evarist; Sorianello, Eleonora; Sebastian, David; Rodriguez-Cuenca, Sergio; Ribas, Vicent; Bonàs-Guarch, Sílvia; Draghici, Sorin; Yang, Chenjing; Mora, Sílvia; Vidal-Puig, Antoni; Dupuis, Josée; Zorzano, Antonio; Torrents, David; Florez, Jose Carlos (Public Library of Science, 2012)
      Type 2 Diabetes (T2D) is a highly prevalent chronic metabolic disease with strong co-morbidity with obesity and cardiovascular diseases. There is growing evidence supporting the notion that a crosstalk between mitochondria ...

    • Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis 

      Kang, Sona; Tsai, Linus T.; Zhou, Yiming; Evertts, Adam; Xu, Su; Griffin, Michael J.; Issner, Robbyn; Whitton, Holly J.; Garcia, Benjamin A.; Epstein, Charles B.; Mikkelsen, Tarjei S.; Rosen, Evan D. (2014)
      Summary Insulin resistance is a sine qua non of Type 2 diabetes (T2D) and a frequent complication of multiple clinical conditions, including obesity, aging, and steroid use, among others. How such a panoply of insults can ...

    • Identification of Orch3, a Locus Controlling Dominant Resistance to Autoimmune Orchitis, as Kinesin Family Member 1C 

      del Rio, Roxana; McAllister, Ryan D.; Meeker, Nathan D.; Wall, Emma H.; Bond, Jeffrey P.; Kyttaris, Vasileios; Tsokos, George C.; Tung, Kenneth S. K.; Teuscher, Cory (Public Library of Science, 2012)
      Experimental autoimmune orchitis (EAO), the principal model of non-infectious testicular inflammatory disease, can be induced in susceptible mouse strains by immunization with autologous testicular homogenate and appropriate ...

    • Identification of Podocalyxin as a Candidate Gene in Focal Segmental Glomerulosclerosis 

      Shieh, Eric (2015-06-08)
      Studies of rare monogenetic forms of the glomerular kidney disease focal segmental glomerulosclerosis (FSGS) have highlighted the importance of the podocyte in glomerular filtration. Recent reports have also demonstrated ...

    • Identification of Potent Ebola Virus Entry Inhibitors with Suitable Properties for in Vivo Studies 

      Liu, Hu; Tian, Ye; Lee, Kyungae; Krishnan, Pranav; Wang, May Kwang-Mei; Whelan, Sean P.J.; Mevers, Emily Elizabeth; Soloveva, Veronica; Dedic, Benjamin; Liu, Xinyong; Cunningham, James Morgan; Whelan, Sean (American Chemical Society (ACS), 2018-06-19)
      Previous studies identified an adamantane dipeptide piperazine 3.47 that inhibits Ebola virus (EBOV) infection by targeting the essential receptor Niemann–Pick C1 (NPC1). The physicochemical properties of 3.47 limit its ...

    • Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi 

      Housden, Benjamin; Valvezan, Alexander; Kelley, Colleen; Sopko, Richelle; Hu, Yanhui; Roesel, Charles; Lin, Shuailiang; Buckner, Michael; Tao, Rong; Yilmazel, Bahar; Mohr, Stephanie; Manning, Brendan; Perrimon, Norbert (American Association for the Advancement of Science, 2015)
      The tuberous sclerosis complex (TSC) family of tumor suppressors, TSC1 and TSC2, function together in an evolutionarily conserved protein complex that is a point of convergence for major cell signaling pathways that regulate ...

    • The Identification of Prognostic Factors and Survival Statistics of Conventional Central Chondrosarcoma 

      Nota, Sjoerd P. F. T.; Braun, Yvonne; Schwab, Joseph H.; van Dijk, C. Niek; Bramer, Jos A. M. (Hindawi Publishing Corporation, 2015)
      Introduction:. Chondrosarcomas are malignant bone tumors that are characterized by the production of chondroid tissue. Since radiation therapy and chemotherapy have limited effect on chondrosarcoma, treatment of most ...

    • Identification of promoter targets of enhancers by epigenetic knockdown using TAL DNA binding proteins 

      Mendenhall, Eric M; Williamson, Kaylyn Elise; Reyon, Deepak; Joung, Jae Keith; Bernstein, Bradley E. (BioMed Central, 2013)

    • Identification of Protective Pneumococcal \(T_{H}17\) Antigens from the Soluble Fraction of a Killed Whole Cell Vaccine 

      Moffitt, Kristin Leigh; Malley, Richard; Lu, Ying-Jie (Public Library of Science, 2012)
      Mucosal or parenteral immunization with a killed unencapsulated pneumococcal whole cell antigen (WCA) with an adjuvant protects mice from colonization by a \(T_{H}17\) CD4+ cell-mediated mechanism. Using preparative SDS ...

    • Identification of proteins found to be significantly altered when comparing the serum proteome from Multiple Myeloma patients with varying degrees of bone disease 

      Dowling, Paul; Hayes, Catriona; Ting, Kay Reen; Hameed, Abdul; Meiller, Justine; Mitsiades, Constantine; Anderson, Kenneth C; Clynes, Martin; Clarke, Colin; Richardson, Paul; O’Gorman, Peter (BioMed Central, 2014)
      Background: Bone destruction is a feature of multiple myeloma, characterised by osteolytic bone destruction due to increased osteoclast activity and suppressed or absent osteoblast activity. Almost all multiple myeloma ...