Browsing Harvard Medical School by Title
Now showing items 8360-8379 of 18428
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Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer
(National Academy of Sciences, 2009)In cancer, genetically activated proto-oncogenes often induce "upstream'' dependency on the activity of the mutant oncoprotein. Therapeutic inhibition of these activated oncoproteins can induce massive apoptosis of tumor ... -
Identifying Health Information Technology Needs of Oncologists to Facilitate the Adoption of Genomic Medicine: Recommendations From the 2016 American Society of Clinical Oncology Omics and Precision Oncology Workshop
At the ASCO Data Standards and Interoperability Summit held in May 2016, it was unanimously decided that four areas of current oncology clinical practice have serious, unmet health information technology needs. The following ... -
Identifying Indicators of Important Diagnostic Features of Delirium
(Wiley-Blackwell, 2012)OBJECTIVES: To use an expert consensus process to identify indicators of delirium features to help enhance bedside recognition of delirium. DESIGN: Modified Delphi consensus process to assign existing cognitive and ... -
Identifying Intestinal Metaplasia at the Squamocolumnar Junction by Using Optical Coherence Tomography
(Elsevier BV, 2007)Background: Optical coherence tomography (OCT) is an optical imaging method that produces high-resolution cross-sectional images of the esophagus. The accuracy of OCT for differentiating tissue types at the squamocolumnar ... -
Identifying Key Drivers of Frequent Urgent Care Visits at the Massachusetts General Hospital Chelsea Healthcare Center (MGH-Chelsea)
(2015-06-17)Background: Frequent users of the emergency room are described as medically- and socially-complex and suffer from high rates of morbidity and mortality. However an over-reliance on ER services compromises continuity and ... -
Identifying Long Non-Coding RNAs Associated with a Protective Type I Interferon Signature in Melanoma
(2023-05-10)Long non-coding RNAs (lncRNAs) have emerged as a new class of regulators of type I interferon (IFN) signaling and can potentially serve as therapeutic targets.1 In this study, we identified lncRNAs that are associated with ... -
Identifying Medicare beneficiaries with dementia
(Wiley, 2021-04-26)BACKGROUND/OBJECTIVES: No data exist regarding the validity of International Classification of Disease (ICD)-10 dementia diagnoses within Medicare claims data. We examined the accuracy of claims-based diagnoses with respect ... -
Identifying Metabolic Enzymes with Multiple Types of Association Evidence
(BioMed Central, 2006)Background: Existing large-scale metabolic models of sequenced organisms commonly include enzymatic functions which can not be attributed to any gene in that organism. Existing computational strategies for identifying such ... -
Identifying Metabolic Subpopulations from Population Level Mass Spectrometry
(Public Library of Science, 2016)Metabolism underlies many important cellular decisions, such as the decisions to proliferate and differentiate, and defects in metabolic signaling can lead to disease and aging. In addition, metabolic heterogeneity can ... -
Identifying Novel Genomic Variants in Hemophagocytic Lymphohistiocytosis in Adults
(2021-05-27)Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disorder of immune system overactivation that occurs in familial (primary) and acquired (secondary) forms. While primary HLH is caused by inherited ... -
Identifying Pediatric Mood Disorders From Transdiagnostic Polygenic Risk Scores
(Physicians Postgraduate Press, Inc, 2022-04-20)Objective: Mood disorders often co-occur with attention deficit-hyperactive disorder (ADHD), disruptive behavior disorders (DBD), and aggression. We aimed to determine if polygenic risk scores (PRSs) based on external ... -
Identifying Pediatric Mood Disorders From Transdiagnostic Polygenic Risk Scores: A Study of Children and Adolescents
(Physicians Postgraduate Press, Inc, 2022-04-20) -
Identifying Postpartum Intervention Approaches to Prevent Type 2 Diabetes in Women with a History of Gestational Diabetes
(BioMed Central, 2011)Background: Women who develop gestational diabetes mellitus (GDM) have an increased risk for the development of type 2 diabetes. Despite this "window of opportunity," few intervention studies have targeted postpartum women ... -
Identifying Postpartum Intervention Approaches to Reduce Cardiometabolic Risk Among American Indian Women With Prior Gestational Diabetes, Oklahoma, 2012–2013
(Centers for Disease Control and Prevention, 2015)Introduction: Innovative approaches are needed to reduce cardiometabolic risk among American Indian women with a history of gestational diabetes. We assessed beliefs of Oklahoma American Indian women about preventing type ... -
Identifying Primary Care Patients at Risk for Future Diabetes and Cardiovascular Disease Using Electronic Health Records
(BioMed Central, 2009)Background: Prevention of diabetes and coronary heart disease (CHD) is possible but identification of at-risk patients for targeting interventions is a challenge in primary care. Methods: We analyzed electronic health ... -
Identifying regulatory mechanisms using individual variation reveals key role for chromatin modification
(Proceedings of the National Academy of Sciences, 2006-09-19)Sequence polymorphisms affect gene expression by perturbing the complex network of regulatory interactions. We propose a probabilistic method, called Geronemo, which directly aims to identify the mechanism by which genetic ... -
Identifying Targetable Liabilities in Ewing Sarcoma
(2014-07-07)Background: Despite multi-modality therapy, the majority of patients with metastatic or recurrent Ewing sarcoma (ES), the second most common pediatric bone malignancy, will die of their disease. ES tumors express aberrantly ... -
Identifying Targets for COPD Treatment Through Gene Expression Analyses
(Dove Medical Press, 2008)Despite the status of chronic obstructive pulmonary disease (COPD) as a major global health problem, no currently available therapies can limit COPD progression. Therefore, an urgent need exists for the development of new ... -
Identifying the pathways required for coping behaviours associated with sustained pain
(Springer Science and Business Media LLC, 2018-12-10)Animals and humans display two types of responses to noxious stimuli. The first includes reflexive-defensive responses to prevent or limit injury. A well-known example is the quick withdrawal of one’s hand touching a hot ... -
Identifying translational science within the triangle of biomedicine
(BioMed Central, 2013)Background: The National Institutes of Health (NIH) Roadmap places special emphasis on “bench-to-bedside” research, or the “translation” of basic science research into practical clinical applications. The Clinical and ...