Browsing Harvard Medical School by Title

Now showing items 8732-8751 of 18428

    • Improved efficiency for respiratory motion compensation in three-dimensional flow measurements 

      Akcakaya, Mehmet; Gulaka, Praveen; Basha, Tamer; Hauser, Thomas Henry; Manning, Warren J.; Nezafat, Reza (BioMed Central, 2013)

    • Improved Fat Water Separation with Water Selective Inversion Pulse for Inversion Recovery-based Cardiac MRI Sequence 

      Havla, Lukas; Basha, Tamer A; Rayatzadeh, Hussein; Shaw, Jaime L; Manning, Warren J.; Reeder, Scott B; Kozerke, Sebastian; Nezafat, Reza (BioMed Central, 2012)

    • Improved IBD Detection Using Incomplete Haplotype Information 

      Genovese, Giulio; Leibon, Gregory; Pollak, Martin Russell; Rockmore, Daniel N (BioMed Central, 2010)
      Background: The availability of high density genetic maps and genotyping platforms has transformed human genetic studies. The use of these platforms has enabled population-based genome-wide association studies. However, ...

    • Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel 

      Huang, Jie; Howie, Bryan; McCarthy, Shane; Memari, Yasin; Walter, Klaudia; Min, Josine L.; Danecek, Petr; Malerba, Giovanni; Trabetti, Elisabetta; Zheng, Hou-Feng; Al Turki, Saeed; Amuzu, Antoinette; Anderson, Carl A.; Anney, Richard; Antony, Dinu; Artigas, María Soler; Ayub, Muhammad; Bala, Senduran; Barrett, Jeffrey C.; Barroso, Inês; Beales, Phil; Benn, Marianne; Bentham, Jamie; Bhattacharya, Shoumo; Birney, Ewan; Blackwood, Douglas; Bobrow, Martin; Bochukova, Elena; Bolton, Patrick F.; Bounds, Rebecca; Boustred, Chris; Breen, Gerome; Calissano, Mattia; Carss, Keren; Pablo Casas, Juan; Chambers, John C.; Charlton, Ruth; Chatterjee, Krishna; Chen, Lu; Ciampi, Antonio; Cirak, Sebahattin; Clapham, Peter; Clement, Gail; Coates, Guy; Cocca, Massimiliano; Collier, David A.; Cosgrove, Catherine; Cox, Tony; Craddock, Nick; Crooks, Lucy; Curran, Sarah; Curtis, David; Daly, Allan; Day, Ian N. M.; Day-Williams, Aaron; Dedoussis, George; Down, Thomas; Du, Yuanping; van Duijn, Cornelia M.; Dunham, Ian; Edkins, Sarah; Ekong, Rosemary; Ellis, Peter; Evans, David M.; Farooqi, I. Sadaf; Fitzpatrick, David R.; Flicek, Paul; Floyd, James; Foley, A. Reghan; Franklin, Christopher S.; Futema, Marta; Gallagher, Louise; Gasparini, Paolo; Gaunt, Tom R.; Geihs, Matthias; Geschwind, Daniel; Greenwood, Celia; Griffin, Heather; Grozeva, Detelina; Guo, Xiaosen; Guo, Xueqin; Gurling, Hugh; Hart, Deborah; Hendricks, Audrey E.; Holmans, Peter; Huang, Liren; Hubbard, Tim; Humphries, Steve E.; Hurles, Matthew E.; Hysi, Pirro; Iotchkova, Valentina; Isaacs, Aaron; Jackson, David K.; Jamshidi, Yalda; Johnson, Jon; Joyce, Chris; Karczewski, Konrad J.; Kaye, Jane; Keane, Thomas; Kemp, John P.; Kennedy, Karen; Kent, Alastair; Keogh, Julia; Khawaja, Farrah; Kleber, Marcus E.; van Kogelenberg, Margriet; Kolb-Kokocinski, Anja; Kooner, Jaspal S.; Lachance, Genevieve; Langenberg, Claudia; Langford, Cordelia; Lawson, Daniel; Lee, Irene; van Leeuwen, Elisabeth M.; Lek, Monkol; Li, Rui; Li, Yingrui; Liang, Jieqin; Lin, Hong; Liu, Ryan; Lönnqvist, Jouko; Lopes, Luis R.; Lopes, Margarida; Luan, Jian'an; MacArthur, Daniel G.; Mangino, Massimo; Marenne, Gaëlle; März, Winfried; Maslen, John; Matchan, Angela; Mathieson, Iain; McGuffin, Peter; McIntosh, Andrew M.; McKechanie, Andrew G.; McQuillin, Andrew; Metrustry, Sarah; Migone, Nicola; Mitchison, Hannah M.; Moayyeri, Alireza; Morris, James; Morris, Richard; Muddyman, Dawn; Muntoni, Francesco; Nordestgaard, Børge G.; Northstone, Kate; O'Donovan, Michael C.; O'Rahilly, Stephen; Onoufriadis, Alexandros; Oualkacha, Karim; Owen, Michael J.; Palotie, Aarno; Panoutsopoulou, Kalliope; Parker, Victoria; Parr, Jeremy R.; Paternoster, Lavinia; Paunio, Tiina; Payne, Felicity; Payne, Stewart J.; Perry, John R. B.; Pietilainen, Olli; Plagnol, Vincent; Pollitt, Rebecca C.; Povey, Sue; Quail, Michael A.; Quaye, Lydia; Raymond, Lucy; Rehnström, Karola; Ridout, Cheryl K.; Ring, Susan; Ritchie, Graham R. S.; Roberts, Nicola; Robinson, Rachel L.; Savage, David B.; Scambler, Peter; Schiffels, Stephan; Schmidts, Miriam; Schoenmakers, Nadia; Scott, Richard H.; Scott, Robert A.; Semple, Robert K.; Serra, Eva; Sharp, Sally I.; Shaw, Adam; Shihab, Hashem A.; Shin, So-Youn; Skuse, David; Small, Kerrin S.; Smee, Carol; Smith, George Davey; Southam, Lorraine; Spasic-Boskovic, Olivera; Spector, Timothy D.; St Clair, David; St Pourcain, Beate; Stalker, Jim; Stevens, Elizabeth; Sun, Jianping; Surdulescu, Gabriela; Suvisaari, Jaana; Syrris, Petros; Tachmazidou, Ioanna; Taylor, Rohan; Tian, Jing; Tobin, Martin D.; Toniolo, Daniela; Traglia, Michela; Tybjaerg-Hansen, Anne; Valdes, Ana M.; Vandersteen, Anthony M.; Varbo, Anette; Vijayarangakannan, Parthiban; Visscher, Peter M.; Wain, Louise V.; Walters, James T. R.; Wang, Guangbiao; Wang, Jun; Wang, Yu; Ward, Kirsten; Wheeler, Eleanor; Whincup, Peter; Whyte, Tamieka; Williams, Hywel J.; Williamson, Kathleen A.; Wilson, Crispian; Wilson, Scott G.; Wong, Kim; Xu, ChangJiang; Yang, Jian; Zaza, Gianluigi; Zeggini, Eleftheria; Zhang, Feng; Zhang, Pingbo; Zhang, Weihua; Gambaro, Giovanni; Richards, J. Brent; Durbin, Richard; Timpson, Nicholas J.; Marchini, Jonathan; Soranzo, Nicole (Nature Pub. Group, 2015)
      Imputing genotypes from reference panels created by whole-genome sequencing (WGS) provides a cost-effective strategy for augmenting the single-nucleotide polymorphism (SNP) content of genome-wide arrays. The UK10K Cohorts ...

    • Improved imputation quality of low-frequency and rare variants in European samples using the ‘Genome of The Netherlands' 

      Deelen, Patrick; Menelaou, Androniki; van Leeuwen, Elisabeth M; Kanterakis, Alexandros; van Dijk, Freerk; Medina-Gomez, Carolina; Francioli, Laurent C; Hottenga, Jouke Jan; Karssen, Lennart C; Estrada, Karol; Kreiner-Møller, Eskil; Rivadeneira, Fernando; van Setten, Jessica; Gutierrez-Achury, Javier; Westra, Harm-Jan; Franke, Lude; van Enckevort, David; Dijkstra, Martijn; Byelas, Heorhiy; van Duijn, Cornelia M; Swertz, Morris A; Neerincx, Pieter B T; Pulit, Sara L; Elbers, Clara C; Francesco Palamara, Pier; Pe'er, Itsik; Abdellaoui, Abdel; Kloosterman, Wigard P; van Oven, Mannis; Vermaat, Martijn; Li, Mingkun; Laros, Jeroen F J; Stoneking, Mark; de Knijff, Peter; Kayser, Manfred; Veldink, Jan H; van den Berg, Leonard H; den Dunnen, Johan T; Amin, Najaf; van der Velde, K Joeri; Jan Hottenga, Jouke; Kattenberg, Mathijs; van Schaik, Barbera D C; Bot, Jan; Nijman, Isaäuc J; Mei, Hailiang; Koval, Vyacheslav; Ye, Kai; Lameijer, Eric-Wubbo; Moed, Matthijs H; Hehir-Kwa, Jayne Y; Handsaker, Robert E; Sunyaev, Shamil R; Sohail, Mashaal; Hormozdiari, Fereydoun; Marschall, Tobias; Marschall, Schönhuth; Guryev, Victor; de Bakker, Paul I W; Slagboom, P Eline; Beekman, Marian B; de Craen, Anton J M; Suchiman, H Eka D; Hofman, Albert; van Duijn, Cornelia; Boomsma, Dorret I; Willemsen, Gonneke; Wolffenbuttel, Bruce H; Platteel, Mathieu; Pitts, Steven J; Potluri, Shobha; Cox, David R; Li, Qibin; Li, Yingrui; Du, Yuanping; Chen, Ruoyan; Cao, Hongzhi; Li, Ning; Cao, Sujie; Wang, Jun; Bovenberg, Jasper A; committee, Steering; Wijmenga, Cisca; van Ommen, Gertjan B (Nature Publishing Group, 2014)
      Although genome-wide association studies (GWAS) have identified many common variants associated with complex traits, low-frequency and rare variants have not been interrogated in a comprehensive manner. Imputation from ...

    • Improved intravital microscopy via synchronization of respiration and holder stabilization 

      Lee, Sungon; Vinegoni, Claudio; Feruglio, Paolo Fumene; Weissleder, Ralph (Society of Photo-optical Instrumentation Engineers, 2012)
      A major challenge in high-resolution intravital confocal and multiphoton microscopy is physiologic tissue movement during image acquisition. Of the various physiological sources of movement, respiration has arguably the ...

    • Improved Late Gadolinium Enhancement Imaging of Left Ventricle with Isotropic Spatial Resolution 

      Akcakaya, Mehmet; Rayatzadeh, Hussein; Hong, Susie; Hauser, Thomas Henry; Chan, Raymond Ho Ming; Basha, Tamer; Kissinger, Kraig V; Goddu, Beth; Manning, Warren J.; Nezafat, Reza (BioMed Central, 2012)

    • Improved Long-term Expression from Helper Virus-free HSV-1 Vectors Packaged Using Combinations of Mutated HSV-1 Proteins that Include the UL13 Protein Kinase and Specific Components of the VP16 Transcriptional Complex 

      Liu, Meng; Wang, Xiaodan; Geller, Alfred I. (BioMed Central, 2009)
      Background: Herpes Simplex Virus (HSV-1) gene expression is thought to shut off recombinant gene expression from HSV-1 vectors; however, in a helper virus-free HSV-1 vector system, a number of promoters support only ...

    • Improved Long-Term Imaging of Embryos with Genetically Encoded α-Bungarotoxin 

      Swinburne, Ian A.; Mosaliganti, Kishore R.; Green, Amelia A.; Megason, Sean G. (Public Library of Science, 2015)
      Rapid advances in microscopy and genetic labeling strategies have created new opportunities for time-lapse imaging of embryonic development. However, methods for immobilizing embryos for long periods while maintaining ...

    • Improved Navigator-Gated Motion Compensation in Cardiac MR Using Additional Constraint of Magnitude of Motion-Corrupted Data 

      Shaw, Jaime L; Moghari, Mehdi H.; Akcakaya, Mehmet; Chan, Raymond Ho Ming; Manning, Warren J.; Nezafat, Reza (BioMed Central, 2012)
      Background. In conventional prospective respiratory navigator (NAV) acquisitions, 40-60% of the acquired data are discarded resulting in low efficiency and long scan times [1,2].Compressed-sensing Motion Compensation (CosMo) ...

    • Improved Outcome Prediction Using CT Angiography in Addition to Standard Ischemic Stroke Assessment: Results from the STOPStroke Study 

      Lev, Michael Howard; Smith, Wade S.; Payabvash, Seyedmehdi; Harris, Gordon J.; Halpern, Elkan F.; Koroshetz, Walter J.; Dillon, William P.; Furie, Karen L.; Goldmacher, Gregory V.; Camargo, Erica Christina S.; González, Ramon Gilberto (Public Library of Science, 2012)
      Purpose: To improve ischemic stroke outcome prediction using imaging information from a prospective cohort who received admission CT angiography (CTA). Methods: In a prospectively designed study, 649 stroke patients diagnosed ...

    • An improved predictive recognition model for Cys2-His2 zinc finger proteins 

      Gupta, Ankit; Christensen, Ryan G.; Bell, Heather A.; Goodwin, Mathew; Patel, Ronak Y.; Pandey, Manishi; Enuameh, Metewo Selase; Rayla, Amy L.; Zhu, Cong; Thibodeau-Beganny, Stacey; Brodsky, Michael H.; Joung, J. Keith; Wolfe, Scot A.; Stormo, Gary D. (Oxford University Press, 2014)
      Cys2-His2 zinc finger proteins (ZFPs) are the largest family of transcription factors in higher metazoans. They also represent the most diverse family with regards to the composition of their recognition sequences. Although ...

    • An improved ScoreCard to assess the differentiation potential of human pluripotent stem cells 

      Tsankov, Alexander M.; Akopian, Veronika; Pop, Ramona; Chetty, Sundari; Gifford, Casey A.; Daheron, Laurence; Melton, Douglas A.; Tsankova, Nadejda M.; Meissner, Alexander (2015)
      Research on human pluripotent stem cells has been hampered by the lack of a standardized, quantitative, scalable assay of pluripotency. We have previously described an assay called ScoreCard that used gene expression ...

    • Improved Somatic Mutagenesis in Zebrafish Using Transcription Activator-Like Effector Nucleases (TALENs) 

      Moore, Finola Elizabeth; Reyon, Deepak; Sander, Jeffry D.; Martinez, Sarah A.; Blackburn, Jessica S.; Khayter, Cyd; Ramirez, Cherie Lynn; Joung, Jae Keith; Langenau, David M. (Public Library of Science, 2012)
      Zinc Finger Nucleases (ZFNs) made by Context-Dependent Assembly (CoDA) and Transcription Activator-Like Effector Nucleases (TALENs) provide robust and user-friendly technologies for efficiently inactivating genes in ...

    • Improved Therapeutic Monitoring With Several Interventions 

      Feldstein, Adrianne C.; Smith, David H.; Perrin, Nancy; Yang, Xiuhai; Rix, Mary; Raebel, Marsha A.; Magid, David J.; Simon, Steven R.; Soumerai, Stephen Bertram (American Medical Association (AMA), 2006)
      Background Medication errors are frequently related to failure to appropriately select medications or adjust for laboratory parameters. Differences between guideline recommendations and actual frequency of therapeutic ...

    • Improved tracking of sevoflurane anesthetic states with drug-specific machine learning models 

      Kashkooli, Kimia; Polk, Samuel; Hahm, Eunice; Murphy, James; Ethridge, Breanna; Gitlin, Jacob; Ibala, Reine; Mekonnen, Jennifer; Pedemonte, Juan; Sun, Haoqi; Westover, Brandon; Barbieri, Riccardo; Johnson-Akeju, Oluwaseun; Chamadia, Shubham (IOP Publishing, 2020-08-04)

    • Improved Tumor Oxygenation and Survival in Glioblastoma Patients Who Show Increased Blood Perfusion After Cediranib and Chemoradiation 

      Batchelor, Tracy; Gerstner, Elizabeth; Emblem, Kyrre E.; Duda, Dan; Kalpathy-Cramer, Jayashree; Snuderl, Matija; Ancukiewicz, Marek; Polaskova, Pavlina; Pinho, Marco C.; Jennings, Dominique; Plotkin, Scott; Chi, Andrew S.; Eichler, April; Dietrich, Jorg; Hochberg, Fred H.; Lu-Emerson, Christine; Iafrate, Anthony; Ivy, S. Percy; Rosen, Bruce; Loeffler, Jay; Wen, Patrick; Sorenson, A. Greg; Jain, Rakesh (National Academy of Sciences, 2013-11-19)
      Antiangiogenic therapy has shown clear activity and improved survival benefit for certain tumor types. However, an incomplete understanding of the mechanisms of action of antiangiogenic agents has hindered optimization and ...

    • Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer 

      Heist, Rebecca; Duda, Dan; Sahani, Dushyant; Ancukiewicz, Marek; Fidias, Panos; Sequist, Lecia; Temel, Jennifer; Shaw, Alice; Pennell, Nathan; Neal, Joel; Gandhi, Leena; Lynch, Thomas; Engelman, Jeffrey; Jain, Rakesh (National Academy of Sciences, 2015)
      Addition of anti-VEGF antibody therapy to standard chemotherapies has improved survival and is an accepted standard of care for advanced non-small cell lung cancer (NSCLC). However, the mechanisms by which anti-VEGF therapy ...

    • Improved Vascular Engraftment and Graft Function After Inhibition of the Angiostatic Factor Thrombospondin-1 in Mouse Pancreatic Islets 

      Olerud, Johan; Johansson, Magnus; Lawler, Jack William; Welsh, Nils; Carlsson, Per-Ola (American Diabetes Association, 2008)
      Objective: Insufficient development of a new intra-islet capillary network after transplantation may be one contributing factor to the failure of islet grafts in clinical transplantation. The present study tested the ...

    • Improvement and Emergence of Insulin Restriction in Women With Type 1 Diabetes 

      Fikkan, Janna; Franko, Debra L.; Goebel-Fabbri, Ann Elizabeth; Anderson, Barbara Joan; Peasron, Kimberly; Anderson, Barbara Joan; Weinger, Katie (American Diabetes Association, 2011)
      OBJECTIVE To determine the distinguishing characteristics of women who report stopping insulin restriction at 11 years of follow-up from those continuing to endorse insulin restriction as well as those characteristics ...