Browsing Harvard Medical School by Title
Now showing items 9087-9106 of 18428
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The Influence of Skeletal Muscle on Systemic Aging and Lifespan
(Wiley, 2013-12)Epidemiological studies in humans suggest that skeletal muscle aging is a risk factor for the development of several age-related diseases such as metabolic syndrome, cancer, Alzheimer’s disease, and Parkinson’s disease. ... -
Influence of Spatial Resolution on Space-Time Disease Cluster Detection
(Public Library of Science, 2012)Background: Utilizing highly precise spatial resolutions within disease outbreak detection, such as the patients’ address, is most desirable as this provides the actual residential location of the infected individual(s). ... -
The Influence of Stimulus Deviance on Electrophysiologic and Behavioral Responses to Novel Events
(MIT Press - Journals, 2000)This study investigated the role of stimulus deviance in determining electrophysiologic and behavioral responses to “novelty.” Stimulus deviance was defined in terms of differences either from the immediately preceding ... -
Influence of subretinal fluid in advanced stage retinopathy of prematurity on proangiogenic response and cell proliferation
(Molecular Vision, 2014)Purpose The clinical phenotype of advanced stage retinopathy of prematurity (ROP, stages 4 and 5) cannot be replicated in an animal model. To dissect the molecular events that can lead up to advanced ROP, we examined ... -
The Influence of the Patient-Clinician Relationship on Healthcare Outcomes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
(Public Library of Science, 2014)Objective: To determine whether the patient-clinician relationship has a beneficial effect on either objective or validated subjective healthcare outcomes. Design: Systematic review and meta-analysis. Data Sources Electronic ... -
Influence of the sodium channel band on retinal ganglion cell excitation during electric stimulation – A modeling study
(Elsevier BV, 2014-04)Electric stimulation using retinal implants allows blind people to re-experience a rudimentary kind of vision. The elicited percepts or so called ’phosphenes’ are highly inconstant and therefore do not restore vision ... -
Influence of the US President’s Emergency Plan for AIDS Relief (PEPfAR) on career choices and emigration of health-profession graduates from a Ugandan medical school: a cross-sectional study
(BMJ Publishing Group, 2013)Objective: The purpose of this study was to determine the current work distribution of health professionals from a public Ugandan medical school in a period of major donor funding for HIV programmes. We explore the hypothesis ... -
Influences of Chronic Mild Stress Exposure on Motor, Non-Motor Impairments and Neurochemical Variables in Specific Brain Areas of MPTP/Probenecid Induced Neurotoxicity in Mice
(Public Library of Science, 2016)Parkinson's disease (PD) is regarded as a movement disorder mainly affecting the elderly population and occurs due to progressive loss of dopaminergic (DAergic) neurons in nigrostriatal pathway. Patients suffer from non-motor ... -
Influencing the Decline of Lung Function in COPD: Use of Pharmacotherapy
(Dove Medical Press, 2010)Chronic obstructive pulmonary disease (COPD) is a common and deadly disease. One of the hallmarks of COPD is an accelerated decline in lung function, as measured by spirometry. Inflammation, oxidative stress and other ... -
Influenza A Virus Host Shutoff Disables Antiviral Stress-Induced Translation Arrest
(Public Library of Science, 2014)Influenza A virus (IAV) polymerase complexes function in the nucleus of infected cells, generating mRNAs that bear 5′ caps and poly(A) tails, and which are exported to the cytoplasm and translated by host machinery. Host ... -
Influenza and Ultraviolet Germicidal Irradiation
(BioMed Central, 2008) -
Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates
(eLife Sciences Publications, Ltd, 2013)Influenza virus penetrates cells by fusion of viral and endosomal membranes catalyzed by the viral hemagglutinin (HA). Structures of the initial and final states of the HA trimer define the fusion endpoints, but do not ... -
Informal urban settlements and cholera risk in Dar es Salaam, Tanzania
(Public Library of Science, 2010)Background: As a result of poor economic opportunities and an increasing shortage of affordable housing, much of the spatial growth in many of the world's fastest-growing cities is a result of the expansion of informal ... -
An information model for computable cancer phenotypes
(BioMed Central, 2016)Background: Standards, methods, and tools supporting the integration of clinical data and genomic information are an area of significant need and rapid growth in biomedical informatics. Integration of cancer clinical data ... -
Information recovery from low coverage whole-genome bisulfite sequencing
(Nature Publishing Group, 2016)The cost of whole-genome bisulfite sequencing (WGBS) remains a bottleneck for many studies and it is therefore imperative to extract as much information as possible from a given dataset. This is particularly important ... -
Information Technology Support for Clinical Genetic Testing within an Academic Medical Center
(MDPI, 2016)Academic medical centers require many interconnected systems to fully support genetic testing processes. We provide an overview of the end-to-end support that has been established surrounding a genetic testing laboratory ... -
Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies
(Public Library of Science, 2012)Genetic case-control association studies often include data on clinical covariates, such as body mass index (BMI), smoking status, or age, that may modify the underlying genetic risk of case or control samples. For example, ... -
Informed Consent and Placebo Effects: A Content Analysis of Information Leaflets to Identify What Clinical Trial Participants Are Told about Placebos
(Public Library of Science, 2012)Background: Placebo groups are used in randomised clinical trials (RCTs) to control for placebo effects, which can be large. Participants in trials can misunderstand written information particularly regarding technical ... -
Informed consent and research design in critical care medicine
(BioMed Central, 1999) -
The Informed Consent Process in Older Patients Who Developed Delirium
(Elsevier BV, 1997)PURPOSE: Delirium, defined as an acute, fluctuating disorder of attention and cognition, is a serious and increasingly common problem for hospitalized older persons. Delirium poses unique ethical challenges for the informed ...