Browsing Harvard Medical School by Title

Now showing items 912-931 of 18427

    • Antibodies to PfSEA-1 Block Parasite Egress From RBCs and Protect Against Malaria Infection 

      Raj, Dipak K; Nixon, C. P.; Nixon, C. E.; Dvorin, Jeffrey; DiPetrillo, C. G.; Pond-Tor, Sunthorn; Wu, H.-W.; Jolly, Grant; Pischel, L.; Lu, A.; Michelow, Ian C.; Cheng, L.; Conteh, S.; McDonald, E. A.; Absalon, Sabrina; Holte, S. E.; Friedman, Jennifer F.; Fried, Michal; Duffy, Patrick E; Kurtis, Jonathan D. (American Association for the Advancement of Science (AAAS), 2014-05-23)

    • Antibody Avidity in Humoral Immune Responses in Bangladeshi Children and Adults following Administration of an Oral Killed Cholera Vaccine 

      Alam, Mohammad Murshid; Leung, Daniel T.; Akhtar, Marjahan; Nazim, Mohammad; Akter, Sarmin; Uddin, Taher; Khanam, Farhana; Mahbuba, Deena Al; Ahmad, Shaikh Meshbahuddin; Bhuiyan, Taufiqur Rahman; Calderwood, Stephen B.; Ryan, Edward T.; Qadri, Firdausi (American Society for Microbiology, 2013)
      Antibody avidity for antigens following disease or vaccination increases with affinity maturation and somatic hypermutation. In this study, we followed children and adults in Bangladesh for 1 year following oral cholera ...

    • Antibody Derived Peptides for Detection of Ebola Virus Glycoprotein 

      Rodríguez-Martínez, Luis Mario; Marquez-Ipiña, Alan Roberto; López-Pacheco, Felipe; Pérez-Chavarría, Roberto; González-Vázquez, Juan Carlos; González-González, Everardo; Trujillo-de Santiago, Grissel; Ponce-Ponce de León, César Alejandro; Zhang, Yu Shrike; Dokmeci, Mehmet Remzi; Khademhosseini, Ali; Alvarez, Mario Moisés (Public Library of Science, 2015)
      Background: Current Ebola virus (EBOV) detection methods are costly and impractical for epidemic scenarios. Different immune-based assays have been reported for the detection and quantification of Ebola virus (EBOV) proteins. ...

    • Antibody Engineering & Therapeutics 2016: The Antibody Society's annual meeting, December 11–15, 2016, San Diego, CA 

      Larrick, James W.; Alfenito, Mark R.; Scott, Jamie K.; Parren, Paul W. H. I.; Burton, Dennis R.; Bradbury, Andrew R. M.; Lemere, Cynthia A.; Messer, Anne; Huston, James S.; Carter, Paul J.; Veldman, Trudi; Chester, Kerry A.; Schuurman, Janine; Adams, Gregory P.; Reichert, Janice M. (Taylor & Francis, 2016)
      ABSTRACT Antibody Engineering & Therapeutics, the largest meeting devoted to antibody science and technology and the annual meeting of The Antibody Society, will be held in San Diego, CA on December 11-15, 2016. Each of ...

    • Antibody Responses After Analytic Treatment Interruption in Human Immunodeficiency Virus-1-Infected Individuals on Early Initiated Antiretroviral Therapy 

      Stephenson, Kathryn E.; Neubauer, George H.; Bricault, Christine A.; Shields, Jennifer; Bayne, Madeleine; Reimer, Ulf; Pawlowski, Nikolaus; Knaute, Tobias; Zerweck, Johannes; Seaman, Michael S.; Rosenberg, Eric S.; Barouch, Dan H. (Oxford University Press, 2016)
      The examination of antibody responses in human immunodeficiency virus (HIV)-1-infected individuals in the setting of antiretroviral treatment (ART) interruption can provide insight into the evolution of antibody responses ...

    • Antibody Responses after Intravaginal Immunisation with Trimeric HIV-1CN54 clade C gp140 in Carbopol Gel are Augmented by Systemic Priming or Boosting with an Adjuvanted Formulation 

      Cranage, Martin P.; Fraser, Carol A.; Cope, Alethea; McKay, Paul F.; Cole, Tom; Mahmoud, A. Nasir; Hall, Joanna; Giles, Elaine; Voss, Gerald; Page, Mark; Almond, Neil; Shattock, Robin J.; Seaman, Michael S. (Elsevier Science, 2011)
      Optimum strategies to elicit and maintain antibodies at mucosal portals of virus entry are critical for the development of vaccines against human immunodeficiency virus (HIV). Here we show in non-human primates that a novel ...

    • Antibody Secreting Cell Responses following Vaccination with Bivalent Oral Cholera Vaccine among Haitian Adults 

      Matias, Wilfredo R.; Falkard, Brie; Charles, Richelle C.; Mayo-Smith, Leslie M.; Teng, Jessica E.; Xu, Peng; Kováč, Pavol; Ryan, Edward T.; Qadri, Firdausi; Franke, Molly F.; Ivers, Louise C.; Harris, Jason B. (Public Library of Science, 2016)
      Background: The bivalent whole-cell (BivWC) oral cholera vaccine (Shanchol) is effective in preventing cholera. However, evaluations of immune responses following vaccination with BivWC have been limited. To determine ...

    • An Antibody-Based Leukocyte-Capture Microarray for the Diagnosis of Systemic Lupus Erythematosus 

      Lin, Ming-Wei; Ho, Joshua Wing Kei; Harrison, Leonard C.; dos Remedios, Cristobal G.; Adelstein, Stephen (Public Library of Science, 2013)
      The diagnosis of Systemic Lupus Erythematosus (SLE) is challenging due to its heterogeneous clinical presentation and the lack of robust biomarkers to distinguish it from other autoimmune diseases. Further, currently used ...

    • Antibody-Mediated Immunity to the Obligate Intracellular Bacterial Pathogen Coxiella burnetii is Fc Receptor- and Complement-Independent 

      Shannon, Jeffrey G; Cockrell, Diane C; Takahashi, Kazue; Stahl, Gregory L.; Heinzen, Robert A (BioMed Central, 2009)
      Background: The obligate intracellular bacterial pathogen Coxiella burnetii causes the zoonosis Q fever. The intracellular niche of C. burnetii has led to the assumption that cell-mediated immunity is the most important ...

    • Antibody-Secreting Cell Responses after Vibrio cholerae O1 Infection and Oral Cholera Vaccination in Adults in Bangladesh 

      Rahman, Atiqur; Rashu, Rasheduzzaman; Bhuiyan, Taufiqur Rahman; Chowdhury, Fahima; Khan, Ashraful Islam; Islam, Kamrul; LaRocque, Regina C.; Ryan, Edward T.; Wrammert, Jens; Calderwood, Stephen B.; Qadri, Firdausi; Harris, Jason B. (American Society for Microbiology, 2013)
      Infection with Vibrio cholerae and oral cholera vaccines (OCVs) induce transient circulating plasmablast responses that peak within approximately 7 days after infection or vaccination. We previously demonstrated that ...

    • Anticancer Activity of an Extract from Needles and Twigs of Taxus cuspidata and Its Synergistic Effect as a Cocktail with 5-Fluorouracil 

      Shang, Weihu; Qiao, Jinping; Gu, Chenxin; Yin, Wei; Du, Jinglei; Wang, Wei; Zhu, Meilin; Han, Mei; Lu, Weidong (BioMed Central, 2011)
      Background: Botanical medicines are increasingly combined with chemotherapeutics as anticancer drug cocktails. This study aimed to assess the chemotherapeutic potential of an extract of Taxus cuspidata (TC) needles and ...

    • Anticancer Effect of Fucoidan in Combination with Tyrosine Kinase Inhibitor Lapatinib 

      Oh, Byeongsang; Kim, Jihun; Lu, Weidong; Rosenthal, David (Hindawi Publishing Corporation, 2014)
      Background:. Despite a number of in vitro and in vivo studies reporting the efficacy of fucoidan in treating various cancers, few studies have measured the efficacy of dietary fucoidan (DF) in combination with cancer drugs. ...

    • Anticipation of Monetary Reward Can Attenuate the Vigilance Decrement 

      Esterman, Michael; Grosso, Mallory; Liu, Guanyu; Mitko, Alex; Morris, Rachael; DeGutis, Joseph (Public Library of Science, 2016)
      Motivation and reward can have differential effects on separate aspects of sustained attention. We previously demonstrated that continuous reward/punishment throughout a sustained attention task improves overall performance, ...

    • Anticoagulants and Statins As Pharmacological Agents in Free Flap Surgery: Current Rationale 

      Pršić, Adnan; Kiwanuka, Elizabeth; Caterson, Stephanie A.; Caterson, Edward J. (Open Science Company, LLC, 2015)
      Microvascular free flaps are key components of reconstructive surgery, but despite their common use and usual reliability, flap failures still occur. Many pharmacological agents have been utilized to minimize risk of flap ...

    • An Antifouling Coating That Enables Affinity-Based Electrochemical Biosensing in Complex Biological Fluids 

      Sabaté del Río, Jonathan; Henry, Olivier; Jolly, Pawan; Ingber, Donald (Springer Science and Business Media LLC, 2019-11-11)
      Affinity-based electrochemical detection in complex biological fluids could enable multiplexed point-of-care (POC) diagnostics for home healthcare; however, commercialisation of POC devices has been limited by rapid loss ...

    • Antigen Cross-Presentation of Immune Complexes 

      Platzer, Barbara; Stout, Madeleine; Fiebiger, Edda (Frontiers Media S.A., 2014)
      The ability of dendritic cells (DCs) to cross-present tumor antigens has long been a focus of interest to physicians, as well as basic scientists, that aim to establish efficient cell-based cancer immune therapy. A ...

    • Antigen identification and high-throughput interaction mapping by reprogramming viral entry 

      Dobson, Connor; Reich, Anna; Gaglione, Stephanie; Smith, Blake; Kim, Ellen; Dong, Jiayi; Ronsard, Larance; Okonkwo, Vintus; Lingwood, Daniel; Dougan, Michael; Dougan, Stephanie; Brinbaum, Michael (Springer Science and Business Media LLC, 2022-04)
      Deciphering immune recognition is critical to understanding a broad range of diseases, and to develop effective vaccines and immunotherapies. Efforts to do so are limited by a lack of technologies capable of simultaneously ...

    • Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1–Specific CD8+ T Cells 

      Brumme, Zabrina L; Anastario, Michael; Cohen, Kristin W; Jolin, Jonathan S; Brumme, Chanson J; Streeck, Hendrik; Meier, Angela; Rosenberg, Eric Scott; Alter, Galit; Allen, Todd; Walker, Bruce David; Altfeld, Marcus (Public Library of Science, 2008)
      Background: Virus-specific CD8+ T lymphocytes play a key role in the initial reduction of peak viremia during acute viral infections, but display signs of increasing dysfunction and exhaustion under conditions of chronic ...

    • Antigen-mediated T cell expansion regulated by parallel pathways of death 

      Ch'en, Irene L.; Beisner, Daniel R.; Degterev, Alexei; Lynch, Candace; Yuan, Junying; Hoffmann, Alexander; Hedrick, Stephen M. (National Academy of Sciences, 2008)
      T cells enigmatically require caspase-8, an inducer of apoptosis, for antigen-driven expansion and effective antiviral responses, and yet the pathways responsible for this effect have been elusive. A defect in caspase-8 ...

    • Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination 

      Mahan, Alison E.; Jennewein, Madeleine F.; Suscovich, Todd; Dionne, Kendall; Tedesco, Jacquelynne; Chung, Amy W.; Streeck, Hendrik; Pau, Maria; Schuitemaker, Hanneke; Francis, Don; Fast, Patricia; Laufer, Dagna; Walker, Bruce D.; Baden, Lindsey; Barouch, Dan H.; Alter, Galit (Public Library of Science, 2016)
      Antibody effector functions, such as antibody-dependent cellular cytotoxicity, complement deposition, and antibody-dependent phagocytosis, play a critical role in immunity against multiple pathogens, particularly in the ...