Browsing Harvard Medical School by Title
Now showing items 9197-9216 of 18428
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Insights from COVID-19 Pandemic for improving HMS Medical Student Clerkship Patient Care and Learning Experiences
(2021-08-30)Introduction: Medical students represent key stakeholders whose perspectives are often lacking in curricular design. In response to the COVID-19 pandemic, medical education shifted abruptly from in-person clinical experience ... -
Insights into Assessing the Genetics of Endometriosis
(Current Science Inc., 2012)Endometriosis is a complex disease arising from the interplay between multiple genetic and environmental factors. The genetic variants potentially underlying the hereditary component of endometriosis have been widely ... -
Insights into Imaging of Aortitis
(Springer-Verlag, 2012)Background: Aortitis is a subtype of the more general term “vasculitis”, an inflammatory condition of infectious or noninfectious origin involving the vessel wall. The term “vasculitis” refers to a broad spectrum of diseases ... -
Insights into the Evolution of Longevity from the Bowhead Whale Genome
(Cell Press, 2015)Summary The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, ... -
Insights into Vibrio cholerae Intestinal Colonization from Monitoring Fluorescently Labeled Bacteria
(Public Library of Science, 2014)Vibrio cholerae, the agent of cholera, is a motile non-invasive pathogen that colonizes the small intestine (SI). Most of our knowledge of the processes required for V. cholerae intestinal colonization is derived from ... -
Insights on the trafficking and retro-translocation of glycosphingolipid-binding bacterial toxins
(Frontiers Media S.A., 2012)Some bacterial toxins and viruses have evolved the capacity to bind mammalian glycosphingolipids to gain access to the cell interior, where they can co-opt the endogenous mechanisms of cellular trafficking and protein ... -
InSite: a computational method for identifying protein-protein interaction binding sites on a proteome-wide scale
(BioMed Central, 2007)We propose InSite, a computational method that integrates high-throughput protein and sequence data to infer the specific binding regions of interacting protein pairs. We compared our predictions with binding sites in ... -
Insomnia, Health-Related Quality of Life and Health Outcomes in Children: A Seven Year Longitudinal Cohort
(Nature Publishing Group, 2016)Insomnia is common in children, and is associated with decreased school performance and increased psychopathology. Although adult insomnia is linked to worsened health-related quality of life (HRQOL), there is insufficient ... -
Institution specific risk factors for 30 day readmission at a community hospital: a retrospective observational study
(BioMed Central, 2014)Background: As of October 1, 2012, hospitals in the United States with excess readmissions based on the Centers for Medicare and Medicaid Services (CMS) risk-adjusted ratio began being penalized. Given the impact of high ... -
Instrumental Music Influences Recognition of Emotional Body Language
(Springer US, 2009)In everyday life, emotional events are perceived by multiple sensory systems. Research has shown that recognition of emotions in one modality is biased towards the emotion expressed in a simultaneously presented but task ... -
Insufficiency of Janus Kinase 2-Autonomous Leptin Receptor Signals for Most Physiologic Leptin Actions
(American Diabetes Association, 2010)OBJECTIVE: Leptin acts via its receptor (LepRb) to signal the status of body energy stores. Leptin binding to LepRb initiates signaling by activating the associated Janus kinase 2 (Jak2) tyrosine kinase, which promotes the ... -
Insulator dysfunction and oncogene activation in IDH mutant gliomas
(2015)Gain-of-function IDH mutations are initiating events that define major clinical and prognostic classes of gliomas1,2. Mutant IDH protein produces a novel onco-metabolite, 2-hydroxyglutarate (2-HG), that interferes with ... -
Insulin Action in Brain Regulates Systemic Metabolism and Brain Function
(American Diabetes Association, 2014)Insulin receptors, as well as IGF-1 receptors and their postreceptor signaling partners, are distributed throughout the brain. Insulin acts on these receptors to modulate peripheral metabolism, including regulation of ... -
Insulin and Insulin-like Growth Factor-1 Receptors Act as Ligand-specific Amplitude Modulators of a Common Pathway Regulating Gene Transcription
(American Society for Biochemistry and Molecular Biology, 2010)Insulin and insulin-like growth factor-1 (IGF-1) act on highly homologous receptors, yet in vivo elicit distinct effects on metabolism and growth. To investigate how the insulin and IGF-1 receptors exert specificity in ... -
Insulin Augmentation of Glucose-Stimulated Insulin Secretion Is Impaired in Insulin-Resistant Humans
(American Diabetes Association, 2012)Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic β-cell dysfunction, the latter possibly caused by a defect in insulin signaling in β-cells. We hypothesized that insulin’s effect to potentiate ... -
Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood
(Elsevier, 2016)Background: Insulin, a pleotrophic hormone, has diverse effects in the body. Recent work has highlighted the important role of insulin's action in the nervous system on glucose and energy homeostasis, memory, and mood. ... -
Insulin Receptor Activation with Transmembrane Domain Ligands
(American Society for Biochemistry and Molecular Biology, 2014)Complementary surfaces are buried when peptide hormones, growth factors, or cytokines bind and activate cellular receptors. Although these extended surfaces provide high affinity and specificity to the interactions, they ... -
Insulin Receptor Substrate 1 Gene Variation Modifies Insulin Resistance Response to Weight-Loss Diets in a 2-Year Randomized Trial: The Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) Trial
(Ovid Technologies (Wolters Kluwer Health), 2011)BACKGROUND: Common genetic variants in the insulin receptor substrate 1 (IRS1) gene have been recently associated with insulin resistance and hyperinsulinemia. We examined whether the best-associated variant modifies the ... -
Insulin receptor substrate 1 is a substrate of the Pim protein kinases
(Impact Journals LLC, 2016)The Pim family of serine/threonine protein kinases (Pim 1, 2, and 3) contribute to cellular transformation by regulating glucose metabolism, protein synthesis, and mitochondrial oxidative phosphorylation. Drugs targeting ... -
Insulin Resistance Alters Islet Morphology in Nondiabetic Humans
(American Diabetes Association, 2014)Type 2 diabetes is characterized by poor glucose uptake in metabolic tissues and manifests when insulin secretion fails to cope with worsening insulin resistance. In addition to its effects on skeletal muscle, liver, and ...