Browsing Harvard Medical School by Title

Now showing items 9414-9433 of 18428

    • Interobserver Variability in the Diagnosis of Crypt Dysplasia in Barrett Esophagus 

      Coco, Dominique P.; Goldblum, John R.; Hornick, Jason L.; Lauwers, Gregory Y.; Montgomery, Elizabeth; Srivastava, Amitabh; Wang, Helen; Odze, Robert D. (Ovid Technologies (Wolters Kluwer Health), 2011)
      Recent morphologic and molecular evidence suggests that dysplasia in Barrett esophagus (BE) begins in the bases of the crypts [crypt dysplasia (CD)] and progresses with time to involve the upper portions of the crypts and ...

    • Interocular Shift of Visual Attention Enhances Stereopsis and Visual Acuities of Anisometropic Amblyopes beyond the Critical Period of Visual Development: A Novel Approach 

      Huang, Liwen; Sun, Xinghuai; Luo, Gang; Liu, Shuai; Liu, Rui; Mansouri, Behzad; Wong, Vicky wing lai; Wen, Wen; Liu, Hong; Wang, Ai-Hou (Hindawi Publishing Corporation, 2014)
      Aims. Increasing evidence shows that imbalanced suppressive drive prior to binocular combination may be the key factor in amblyopia. We described a novel binocular approach, interocular shift of visual attention (ISVA), ...

    • Interorgan Communication Pathways in Physiology: Focus on Drosophila 

      Droujinine, Ilia; Perrimon, Norbert (Annual Reviews, 2016)
      Studies in mammals and Drosophila have demonstrated the existence and significance of secreted factors involved in communication between distal organs. In this review, primarily focusing on Drosophila, we examine the known ...

    • Interphotoreceptor matrix-poly(ϵ-caprolactone) composite scaffolds for human photoreceptor differentiation 

      Baranov, Petr; Michaelson, Andrew; Kundu, Joydip; Carrier, Rebecca L; Young, Michael (SAGE Publications, 2014)
      Tissue engineering has been widely applied in different areas of regenerative medicine, including retinal regeneration. Typically, artificial biopolymers require additional surface modification (e.g. with arginine–glycin ...

    • Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection 

      Penaloza-MacMaster, Pablo; Kamphorst, Alice O.; Wieland, Andreas; Araki, Koichi; Iyer, Smita S.; West, Erin E.; O’Mara, Leigh; Yang, Shu; Konieczny, Bogumila T.; Sharpe, Arlene H.; Freeman, Gordon J.; Rudensky, Alexander Y.; Ahmed, Rafi (The Rockefeller University Press, 2014)
      Regulatory T (T reg) cells are critical for preventing autoimmunity mediated by self-reactive T cells, but their role in modulating immune responses during chronic viral infection is not well defined. To address this ...

    • Interplay between Structure-Specific Endonucleases for Crossover Control during Caenorhabditis elegans Meiosis 

      Saito, Takamune T.; Lui, Doris Y.; Kim, Hyun-Min; Meyer, Katherine; Colaiácovo, Monica P. (Public Library of Science, 2013)
      The number and distribution of crossover events are tightly regulated at prophase of meiosis I. The resolution of Holliday junctions by structure-specific endonucleases, including MUS-81, SLX-1, XPF-1 and GEN-1, is one of ...

    • Interpreting Cancer Genomes Using Systematic Host Perturbations by Tumour Virus Proteins 

      Rozenblatt-Rosen, Orit; Deo, Rahul C.; Dricot, Amélie; Askenazi, Manor; Tavares, Maria; Abderazzaq, Fieda; Byrdsong, Danielle; Correll, Mick; Fan, Changyu; Feltkamp, Mariet C.; Franchi, Rachel; Garg, Brijesh K.; Gulbahce, Natali; Hao, Tong; Korkhin, Anna; Litovchick, Larisa; Mar, Jessica C.; Pak, Theodore R.; Rabello, Sabrina; Rubio, Renee; Shen, Yun; Tasan, Murat; Wanamaker, Shelly; Roecklein-Canfield, Jennifer; Johannsen, Eric; Barabási, Albert-László; Padi, Megha; Adelmant, Guillaume; Calderwood, Michael A; Rolland, Thomas; Grace, Miranda; Pevzner, Samuel; Carvunis, Anne-Ruxandra; Chen, Alyce Aura; Cheng, Jingwei; Duarte, Melissa; Ficarro, Scott; Holthaus, Amy Marie; James, Robert; Singh, Saurav; Spangle, Jennifer Marie; Webber, James T.; Beroukhim, Rameen; Kieff, Elliott D.; Cusick, Michael; Hill, David E.; Munger, Karl; Marto, Jarrod; Quackenbush, John; Roth, Frederick Phillip; DeCaprio, James A.; Vidal, Marc (Nature Publishing Group, 2012)
      Genotypic differences greatly influence susceptibility and resistance to disease. Understanding genotype-phenotype relationships requires that phenotypes be viewed as manifestations of network properties, rather than simply ...

    • Interpreting Expression Data with Metabolic Flux Models: Predicting Mycobacterium tuberculosis Mycolic Acid Production 

      Colijn, Caroline; Brandes, Aaron; Zucker, Jeremy Daniel Hofeld; Lun, Desmond S.; Weiner, Brian; Farhat, Maha Reda; Cheng, Tan-Yun; Moody, D Branch; Murray, Megan Blanche; Galagan, James E (Public Library of Science, 2009)
      Metabolism is central to cell physiology, and metabolic disturbances play a role in numerous disease states. Despite its importance, the ability to study metabolism at a global scale using genomic technologies is limited. ...

    • Interrater Reliability of mHealth App Rating Measures: Analysis of Top Depression and Smoking Cessation Apps 

      Powell, Adam C; Torous, John; Chan, Steven; Raynor, Geoffrey Stephen; Shwarts, Erik; Shanahan, Meghan; Landman, Adam B (JMIR Publications Inc., 2016)
      Background: There are over 165,000 mHealth apps currently available to patients, but few have undergone an external quality review. Furthermore, no standardized review method exists, and little has been done to examine the ...

    • Interrelationship of Multiple Endothelial Dysfunction Biomarkers with Chronic Kidney Disease 

      Chen, Jing; Hamm, L. Lee; Mohler, Emile R.; Hudaihed, Alhakam; Arora, Robin; Chen, Chung-Shiuan; Liu, Yanxi; Browne, Grace; Mills, Katherine T.; Kleinpeter, Myra A.; Simon, Eric E.; Rifai, Nader; Klag, Michael J.; He, Jiang (Public Library of Science, 2015)
      The interrelationship of multiple endothelial biomarkers and chronic kidney disease (CKD) has not been well studied. We measured asymmetric dimethylarginine (ADMA), L-arginine, soluble intercellular adhesion molecule-1 ...

    • Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics 

      Swearingen, Kristian E.; Lindner, Scott E.; Shi, Lirong; Shears, Melanie J.; Harupa, Anke; Hopp, Christine S.; Vaughan, Ashley M.; Springer, Timothy A.; Moritz, Robert L.; Kappe, Stefan H. I.; Sinnis, Photini (Public Library of Science, 2016)
      Malaria parasite infection is initiated by the mosquito-transmitted sporozoite stage, a highly motile invasive cell that targets hepatocytes in the liver for infection. A promising approach to developing a malaria vaccine ...

    • Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models 

      Jarzabek, M A; Amberger-Murphy, V; Callanan, J J; Gao, C; Zagozdzon, A M; Shiels, L; Wang, J; Ligon, K L; Rich, B E; Dicker, P; Gallagher, W M; Prehn, J H M; Byrne, A T (Nature Publishing Group, 2014)
      Background: Glioblastoma (GBM), being a highly vascularised and locally invasive tumour, is an attractive target for anti-angiogenic and anti-invasive therapies. The GBM/endothelial cell response to gossypol/temozolomide ...

    • Interrogation of human hematopoiesis at single-cell and single-variant resolution 

      Ulirsch, Jacob; Lareau, Caleb A.; Bao, Erik L.; Ludwig, Leif S.; Guo, Michael H.; Benner, Christian; Satpathy, Ansuman T.; Kartha, Vinay; Salem, Rany M.; Hirschhorn, Joel; Finucane, Hilary; Aryee, Martin; Buenrostro, Jason; Sankaran, Vijay (Springer Science and Business Media LLC, 2019-03-11)
      Widespread linkage disequilibrium and incomplete annotation of cell-to-cell state variation represent substantial challenges to elucidating mechanisms of trait-associated genetic variation. Here, we perform genetic ...

    • Interspecies Interactions Stimulate Diversification of the Streptomyces coelicolor Secreted Metabolome 

      Traxler, Matthew F.; Watrous, Jeramie D.; Alexandrov, Theodore; Dorrestein, Pieter C.; Kolter, Roberto (American Society of Microbiology, 2013)
      ABSTRACT Soils host diverse microbial communities that include filamentous actinobacteria (actinomycetes). These bacteria have been a rich source of useful metabolites, including antimicrobials, antifungals, anticancer ...

    • Interstitial Fluid: The Overlooked Component of the Tumor Microenvironment? 

      Wiig, Helge; Tenstad, Olav; Iversen, Per Ole; Kalluri, Raghu; Bjerkvig, Rolf (BioMed Central, 2010)
      Background: The interstitium, situated between the blood and lymph vessels and the cells, consists of a solid or matrix phase and a fluid phase, together constituting the tissue microenvironment. Here we focus on the ...

    • Intertissue Control of the Nucleolus via a Myokine-Dependent Longevity Pathway 

      Demontis, Fabio; Patel, Vishal K.; Swindell, William R.; Perrimon, Norbert (Elsevier BV, 2014-06-12)
      Recent evidence indicates that skeletal muscle influences systemic aging but little is known on the signaling pathways and muscle-released cytokines (myokines) responsible for this inter-tissue communication. Here, we show ...

    • Interventions designed to improve the quality and efficiency of medication use in managed care: A critical review of the literature – 2001–2007 

      Lu, Christine Y.; Ross-Degnan, Dennis; Soumerai, Stephen Bertram; Pearson, Sallie-Anne (BioMed Central, 2008)
      Background: Managed care organizations use a variety of strategies to reduce the cost and improve the quality of medication use. The effectiveness of such policies is not well understood. The objective of this research was ...

    • Interventions to Improve Adherence and Persistence With Osteoporosis Medications: A Systematic Literature Review 

      Gleeson, T.; Iversen, Maura Daly; Avorn, Jerry Lewis; Brookhart, A. M.; Katz, Jeffrey Neil; Losina, Elena; May, F.; Patrick, A. R.; Shrank, W; Solomon, Daniel Hal; Solomon, Daniel Hal (Springer Science + Business Media, 2009-06-05)
      Summary: Adherence and persistence with osteoporosis medications are poor. We conducted a systematic literature review of interventions to improve adherence and persistence with osteoporosis medications. Seven studies met ...

    • Interventions to Improve Screening and Follow-Up in Primary Care: A Systematic Review of the Evidence 

      Van Cleave, Jeanne; Kuhlthau, Karen Alice; Bloom, Sheila; Newacheck, Paul W.; Nozzolillo, Alixandra A; Homer, Charles Jay; Perrin, James Marc (Elsevier BV, 2012)
      Background The American Academy of Pediatrics and other organizations recommend several screening tests as part of preventive care. The proportion of children who are appropriately screened and who receive follow-up ...

    • Interventions to Slow Aging in Humans: Are We Ready? 

      Longo, Valter D; Antebi, Adam; Bartke, Andrzej; Barzilai, Nir; Brown-Borg, Holly M; Caruso, Calogero; Curiel, Tyler J; de Cabo, Rafael; Franceschi, Claudio; Gems, David; Ingram, Donald K; Johnson, Thomas E; Kennedy, Brian K; Kenyon, Cynthia; Klein, Samuel; Kopchick, John J; Lepperdinger, Guenter; Madeo, Frank; Mirisola, Mario G; Mitchell, James R; Passarino, Giuseppe; Rudolph, Karl L; Sedivy, John M; Shadel, Gerald S; Sinclair, David A; Spindler, Stephen R; Suh, Yousin; Vijg, Jan; Vinciguerra, Manlio; Fontana, Luigi (John Wiley & Sons, Ltd, 2015)
      The workshop entitled ‘Interventions to Slow Aging in Humans: Are We Ready?’ was held in Erice, Italy, on October 8–13, 2013, to bring together leading experts in the biology and genetics of aging and obtain a consensus ...