Now showing items 21-40 of 62

    • ErbB2, EphrinB1, Src Kinase and PTPN13 Signaling Complex Regulates MAP Kinase Signaling in Human Cancers 

      Vermeer, Paola D.; Bell, Megan; Lee, Kimberly; Vermeer, Daniel W.; Wieking, Byrant G.; Bilal, Erhan; Bhanot, Gyan; Ganesan, Shridar; Klingelhutz, Aloysius J.; Hendriks, Wiljan J.; Drapkin, Ronny I.; Lee, John H. (Public Library of Science, 2012)
      In non-cancerous cells, phosphorylated proteins exist transiently, becoming de-phosphorylated by specific phosphatases that terminate propagation of signaling pathways. In cancers, compromised phosphatase activity and/or ...
    • An Erythroid Differentiation Signature Predicts Response to Lenalidomide in Myelodysplastic Syndrome 

      Galili, Naomi; Tamayo, Pablo; Bosco, Jocelyn; Ladd-Acosta, Christine; Raza, Azra; Ebert, Benjamin L.; Mak, Raymond Heungwing; Pretz, Jennifer Lee; Tanguturi, Shyam Kumar; Stone, Richard Maury; Golub, Todd R. (Public Library of Science, 2008)
      Background: Lenalidomide is an effective new agent for the treatment of patients with myelodysplastic syndrome (MDS), an acquired hematopoietic disorder characterized by ineffective blood cell production and a predisposition ...
    • Evaluation of Association of HNF1B Variants with Diverse Cancers: Collaborative Analysis of Data from 19 Genome-Wide Association Studies 

      Elliott, Katherine S.; Zeggini, Eleftheria; McCarthy, Mark I.; Gudmundsson, Julius; Sulem, Patrick; Stacey, Simon N.; Thorlacius, Steinunn; Amundadottir, Laufey; Grönberg, Henrik; Xu, Jianfeng; Gaborieau, Valerie; Eeles, Rosalind A.; Neal, David E.; Donovan, Jenny L.; Hamdy, Freddie C.; Muir, Kenneth; Hwang, Shih-Jen; Spitz, Margaret R.; Zanke, Brent; Carvajal-Carmona, Luis; Brown, Kevin M.; Hayward, Nicholas K.; Macgregor, Stuart; Tomlinson, Ian P. M.; Lemire, Mathieu; Amos, Christopher I.; Murabito, Joanne M.; Isaacs, William B.; Easton, Douglas F.; Brennan, Paul; Barkardottir, Rosa B.; Gudbjartsson, Daniel F.; Rafnar, Thorunn; Chanock, Stephen J.; Stefansson, Kari; Australian Melanoma Family Study Investigators; The PanScan Consortium; Hunter, David J.; Ioannidis, John (Public Library of Science, 2010)
      Background: Genome-wide association studies have found type 2 diabetes-associated variants in the HNF1B gene to exhibit reciprocal associations with prostate cancer risk. We aimed to identify whether these variants may ...
    • Functional Copy-Number Alterations in Cancer 

      Taylor, Barry S.; Barretina, Jordi; Socci, Nicholas D.; DeCarolis, Penelope; Ladanyi, Marc; Sander, Chris; Gibson, Greg; Meyerson, Matthew Langer; Singer, Samuel (Public Library of Science, 2008)
      Understanding the molecular basis of cancer requires characterization of its genetic defects. DNA microarray technologies can provide detailed raw data about chromosomal aberrations in tumor samples. Computational analysis ...
    • Genetic Mechanisms in Apc-Mediated Mammary Tumorigenesis 

      Kuraguchi, Mari; Ohene-Baah, Nana Yaw; Sonkin, Dmitriy; Bronson, Roderick Terry; Kucherlapati, Raju (Public Library of Science, 2009)
      Many components of Wnt/\(\beta\)-catenin signaling pathway also play critical roles in mammary tumor development, yet the role of the tumor suppressor gene APC (adenomatous polyposis coli) in breast oncongenesis is unclear. ...
    • Genome-Wide and Candidate Gene Association Study of Cigarette Smoking Behaviors 

      Caporaso, Neil; Gu, Fangyi; Chatterjee, Nilanjan; Sheng-Chih, Jin; Yu, Kai; Yeager, Meredith; Jacobs, Kevin; Landi, Maria Teresa; Ziegler, Regina G.; Chanock, Stephen; Kraft, Peter; Bergen, Andrew W.; Chen, Constance; Wheeler, William; Hunter, David J.; Hankinson, Susan Elizabeth (Public Library of Science, 2009)
      The contribution of common genetic variation to one or more established smoking behaviors was investigated in a joint analysis of two genome wide association studies (GWAS) performed as part of the Cancer Genetic Markers ...
    • HSPG-Binding Peptide Corresponding to the Exon 6a-Encoded Domain of VEGF Inhibits Tumor Growth by Blocking Angiogenesis in Murine Model 

      Lee, Tong-Young; Folkman, Judah; Javaherian, Kashi (Public Library of Science, 2010)
      Vascular endothelial growth factor VEGF165 is a critical element for development of the vascular system in physiological and pathological angiogenesis. VEGF isoforms have different affinities for heparan sulphate proteoglycan ...
    • Identification and Rational Redesign of Peptide Ligands to CRIP1, A Novel Biomarker for Cancers 

      Hao, Jihua; Serohijos, Adrian; Newton, Gail; Tassone, Gina; Wang, Zuncai; Sgroi, Dennis Charles; Dokholyan, Nikolay V.; Basilion, James P. (Public Library of Science, 2008)
      Cysteine-rich intestinal protein 1 (CRIP1) has been identified as a novel marker for early detection of cancers. Here we report on the use of phage display in combination with molecular modeling to identify a high-affinity ...
    • Impact of Circulating Cholesterol Levels on Growth and Intratumoral Androgen Concentration of Prostate Tumors 

      Mostaghel, Elahe A.; Solomon, Keith R.; Pelton, Kristine; Freeman, Michael R.; Montgomery, R. Bruce (Public Library of Science, 2012)
      Prostate cancer (PCa) is the second most common cancer in men. Androgen deprivation therapy (ADT) leads to tumor involution and reduction of tumor burden. However, tumors eventually reemerge that have overcome the absence ...
    • Induction of Erythroid Differentiation in Human Erythroleukemia Cells by Depletion of Malic Enzyme 2 

      Everett, Peter; Clish, Clary B.; Polymenis, Michael; Ren, Jian-Guo; Seth, Pankaj; Sukhatme, Vikas Pandurang (Public Library of Science, 2010)
      Malic enzyme 2 (ME2) is a mitochondrial enzyme that catalyzes the conversion of malate to pyruvate and CO2 and uses NAD as a cofactor. Higher expression of this enzyme correlates with the degree of cell de-differentiation. ...
    • Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer 

      Dutt, Amit; Ramos, Alex H.; Hammerman, Peter Seth; Mermel, Craig Harold; Cho, Jeonghee; Sharifnia, Tanaz; Chande, Ajit; Tanaka, Kumiko Elisa; Stransky, Nicolas; Greulich, Heidi E.; Gray, Nathanael Schiander; Meyerson, Matthew Langer (Public Library of Science, 2011)
      Background: Squamous cell lung carcinomas account for approximately 25% of new lung carcinoma cases and 40,000 deaths per year in the United States. Although there are multiple genomically targeted therapies for lung ...
    • Integrated Proteomic Analysis of Human Cancer Cells and Plasma from Tumor Bearing Mice for Ovarian Cancer Biomarker Discovery 

      Pitteri, Sharon J.; JeBailey, Lellean; Faça, Vitor M.; Thorpe, Jason D.; Silva, Melissa A.; Ireton, Reneé C.; Horton, Marc B.; Pruitt, Liese C.; Urban, Nicole; Hanash, Samir M.; Nordheim, Alfred; Wang, Hong; Zhang, Qing; Cheng, Yu-Kang; Dinulescu, Daniela M (Public Library of Science, 2009)
      Background: The complexity of the human plasma proteome represents a substantial challenge for biomarker discovery. Proteomic analysis of genetically engineered mouse models of cancer and isolated cancer cells and cell ...
    • Interactions between Plasma Levels of 25-Hydroxyvitamin D, Insulin-Like Growth Factor (IGF)-1 and C-Peptide with Risk of Colorectal Cancer 

      Wu, Kana; Feskanich, Diane; Fuchs, Charles Stewart; Chan, Andrew Tan; Willett, Walter C.; Hollis, Bruce W.; Pollak, Michael N.; Giovannucci, Edward L. (Public Library of Science, 2011)
      Background: Vitamin D status and levels of insulin-like growth factor (IGF)-1 and C-peptide have been implicated in colorectal carcinogenesis. However, in contrast to vitamin D IGF-1 is not an easily modifiable risk factor. ...
    • Limited Awareness and Low Immediate Uptake of Pre-Exposure Prophylaxis among Men Who Have Sex with Men Using an Internet Social Networking Site 

      Krakower, Douglas S.; Mimiaga, Matthew James; Rosenberger, Joshua G.; Novak, David S.; Mitty, Jennifer A.; White, Jaclyn M.; Mayer, Kenneth Hugh (Public Library of Science, 2012)
      Background: In 2010, the iPrEx trial demonstrated that oral antiretroviral pre-exposure prophylaxis (PrEP) reduced the risk of HIV acquisition among high-risk men who have sex with men (MSM). The impact of iPrEx on PrEP ...
    • Lung Adenocarcinoma of Never Smokers and Smokers Harbor Differential Regions of Genetic Alteration and Exhibit Different Levels of Genomic Instability 

      Thu, Kelsie L.; Vucic, Emily A.; Lockwood, William W.; English, John C.; Fu, Rong; Feng, Ziding; MacAulay, Calum E.; Gazdar, Adi F.; Lam, Wan L.; Chari, Rajagopal; Zhang, Wei; Wang, Pei; Lam, Stephen (Public Library of Science, 2012)
      Recent evidence suggests that the observed clinical distinctions between lung tumors in smokers and never smokers (NS) extend beyond specific gene mutations, such as EGFR, EML4-ALK, and KRAS, some of which have been ...
    • Mammalian Target of Rapamycin Is a Therapeutic Target for Murine Ovarian Endometrioid Adenocarcinomas with Dysregulated Wnt/\(\beta\)-Catenin and PTEN 

      Tanwar, Pradeep; Zhang, LiHua; Kaneko-Tarui, Tomoko; Curley, Michael D.; Taketo, Makoto M.; Rani, Poonam; Roberts, Drucilla Jane; Teixeira, Jose M. (Public Library of Science, 2011)
      Despite the fact that epithelial ovarian cancers are the leading cause of death from gynecological cancer, very little is known about the pathophysiology of the disease. Mutations in the WNT and PI3K pathways are frequently ...
    • Micro-Environmental Mechanical Stress Controls Tumor Spheroid Size and Morphology by Suppressing Proliferation and Inducing Apoptosis in Cancer Cells 

      Cheng, Gang; Tse, Janet; Jain, Rakesh K.; Munn, Lance Leon (Public Library of Science, 2009)
      Background: Compressive mechanical stress produced during growth in a confining matrix limits the size of tumor spheroids, but little is known about the dynamics of stress accumulation, how the stress affects cancer cell ...
    • Mucosal Damage and Neutropenia Are Required for Candida albicans Dissemination 

      Koh, Andrew Y; Köhler, Julia R; Coggshall, Kathleen T; Van Rooijen, Nico; Pier, Gerald B. (Public Library of Science, 2008)
      Candida albicans fungemia in cancer patients is thought to develop from initial gastrointestinal (GI) colonization with subsequent translocation into the bloodstream after administration of chemotherapy. It is unclear what ...
    • Multi-Gene Expression Predictors of Single Drug Responses to Adjuvant Chemotherapy in Ovarian Carcinoma: Predicting Platinum Resistance 

      Ferriss, J. Stuart; Kim, Youngchul; Duska, Linda; Birrer, Michael James; Levine, Douglas A.; Moskaluk, Christopher; Theodorescu, Dan; Lee, Jae K. (Public Library of Science, 2012)
      Despite advances in radical surgery and chemotherapy delivery, ovarian cancer is the most lethal gynecologic malignancy. Standard therapy includes treatment with platinum-based combination chemotherapies yet there is no ...
    • NSAIDs Modulate CDKN2A, TP53, and DNA Content Risk for Progression to Esophageal Adenocarcinoma 

      Galipeau, Patricia C; Li, Xiaohong; Blount, Patricia L; Maley, Carlo C; Sanchez, Carissa A; Odze, Robert D.; Ayub, Kamran; Rabinovitch, Peter S; Vaughan, Thomas L; Reid, Brian J (Public Library of Science, 2007)
      Background: Somatic genetic CDKN2A, TP53, and DNA content abnormalities are common in many human cancers and their precursors, including esophageal adenocarcinoma (EA) and Barrett's esophagus (BE), conditions for which ...