Browsing Harvard Medical School by Title
Now showing items 5018-5037 of 18423
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The E-NTPDase Family of Ectonucleotidases: Structure Function Relationships and Pathophysiological Significance
(Springer Netherlands, 2006)Ectonucleotidases are ectoenzymes that hydrolyze extracellular nucleotides to the respective nucleosides. Within the past decade, ectonucleotidases belonging to several enzyme families have been discovered, cloned and ... -
E-selectin inhibition mitigates splenic HSC activation and myelopoiesis in hypercholesterolemic mice with myocardial infarction
(American Heart Association, 2016)Objective Atherosclerosis is a chronic disease characterized by lipid accumulation in the arterial wall. After myocardial infarction (MI), atherosclerotic plaques are infiltrated by inflammatory myeloid cells that aggravate ... -
E-Selectin Mediates Immune Cell Trafficking in Corneal Transplantation
(Ovid Technologies (Wolters Kluwer Health), 2016)Background Immune rejection continues to threaten all tissue transplants. Here we sought to determine whether P- and E- selectin mediate T cell recruitment in corneal transplantation and whether their blockade can reduce ... -
E1A-engineered human umbilical cord mesenchymal stem cells as carriers and amplifiers for adenovirus suppress hepatocarcinoma in mice
(Impact Journals LLC, 2016)Gene therapy is an attractive approach for hepatocellular carcinoma (HCC) patients. Nevertheless, efficient transgene delivery remains a challenge. In this study, we explored a new targeted system based on human umbilical ... -
E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system
(National Academy of Sciences, 2006)In cells expressing human cytornegalovirus US11 protein, newly synthesized MHC class I heavy chains (HCs) are rapidly dislocated from the endoplasmic reticulum (ER) and degraded in the cytosol, a process that is similar ... -
E2a/Pbx1 Induces the Rapid Proliferation of Stem Cell Factor-Dependent Murine Pro-T Cells That Cause Acute T-Lymphoid or Myeloid Leukemias in Mice
(American Society for Microbiology, 2004)Oncoprotein E2a/Pbx1 is produced by the t(1;19) chromosomal translocation of human pre-B acute lymphoblastic leukemia. E2a/Pbx1 blocks differentiation of primary myeloid progenitors but, paradoxically, induces apoptosis ... -
E2F and p53 Induce Apoptosis Independently during Drosophila Development but Intersect in the Context of DNA Damage
(Public Library of Science, 2008)In mammalian cells, RB/E2F and p53 are intimately connected, and crosstalk between these pathways is critical for the induction of cell cycle arrest or cell death in response to cellular stresses. Here we have investigated ... -
Early Adoption of Dabigatran and Its Dosing in US Patients With Atrial Fibrillation: Results From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation
(Blackwell Publishing Ltd, 2013)Background: Dabigatran is a novel oral anticoagulant approved for thromboprophylaxis in atrial fibrillation. Adoption patterns of this new agent in community practice are unknown. Methods and Results: We studied patterns ... -
Early and Efficient Detection of Mycobacterium tuberculosis in Sputum by Microscopic Observation of Broth Cultures
(Public Library of Science, 2013)Early, efficient and inexpensive methods for the detection of pulmonary tuberculosis are urgently needed for effective patient management as well as to interrupt transmission. These methods to detect M. tuberculosis in a ... -
Early behavioral adherence predicts short and long-term weight loss in the POUNDS LOST study
(Springer Nature, 2010)The primary aim of this study was to test the association of early (first 6 months) adherence related to diet, self-monitoring, and attendance with changes in adiposity and cardiovascular risk factors. This study used data ... -
Early Blood Gas Predictors of Bronchopulmonary Dysplasia in Extremely Low Gestational Age Newborns
(Hindawi Publishing Corporation, 2014)Aim. To determine among infants born before the 28th week of gestation to what extent blood gas abnormalities during the first three postnatal days provide information about the risk of bronchopulmonary dysplasia (BPD). ... -
Early Brain Loss in Circuits Affected by Alzheimer’s Disease is Predicted by Fornix Microstructure but may be Independent of Gray Matter
(Frontiers Media S.A., 2014)In a cohort of community-recruited elderly subjects with normal cognition at initial evaluation, we found that baseline fornix white matter (WM) microstructure was significantly correlated with early volumetric longitudinal ... -
Early Category-Specific Cortical Activation Revealed by Visual Stimulus Inversion
(Public Library of Science, 2008)Visual categorization may already start within the first 100-ms after stimulus onset, in contrast with the long-held view that during this early stage all complex stimuli are processed equally and that category-specific ... -
Early Cellular Changes in the Ascending Aorta and Myocardium in a Swine Model of Metabolic Syndrome
(Public Library of Science, 2016)Background: Metabolic syndrome is associated with pathological remodeling of the heart and adjacent vessels. The early biochemical and cellular changes underlying the vascular damage are not fully understood. In this study, ... -
Early child care and obesity at 12 months of age in the Danish National Birth Cohort
(2014)Background/Objectives Evidence suggests that the child care environment may be more obesogenic than the family home, and previous studies have found that child care use may be associated with obesity in children. Few ... -
Early childhood development in Rwanda: a policy analysis of the human rights legal framework
(BioMed Central, 2016)Background: Early childhood development (ECD) is a critical period that continues to impact human health and productivity throughout the lifetime. Failing to provide policies and programs that support optimal developmental ... -
The early decline in renal function in patients with type 1 diabetes and proteinuria predicts the risk of end stage renal disease
(2012)The risk of end-stage renal disease (ESRD) remains high in patients with type 1diabetes and proteinuria; however, little is known about the rate of decline in their renal function. To help determine this we enrolled patients ... -
Early Detection and Prediction of Cardiotoxicity in Chemotherapy-Treated Patients
(Elsevier BV, 2011)As breast cancer survival increases, cardiotoxicity associated with chemotherapeutic regimens such as anthracyclines and trastuzumab becomes a more significant issue. Assessment of the left ventricular (LV) ejection fraction ... -
Early detection of cryptic memory and glucose uptake deficits in pre-pathological APP mice
(Nature Publishing Group, 2016)Earlier diagnosis and treatment of Alzheimer's disease would greatly benefit from the identification of biomarkers at the prodromal stage. Using a prominent animal model of aspects of the disease, we here show using ... -
Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
(MyJove Corporation, 2016)The kidney normally functions to maintain hemodynamic homeostasis and is a major site of damage caused by drug toxicity. Drug-induced nephrotoxicity is estimated to contribute to 19- 25% of all clinical cases of acute ...