Now showing items 18387-18406 of 18423

    • Zcchc11 Uridylates Mature miRNAs to Enhance Neonatal IGF-1 Expression, Growth, and Survival 

      Jones, Matthew R.; Blahna, Matthew T.; Kozlowski, Elyse; Matsuura, Kori Y.; Ferrari, Joseph D.; Morris, Samantha A; Powers, John T; Daley, George Quentin; Quinton, Lee J.; Mizgerd, Joseph P. (Public Library of Science, 2012)
      The Zcchc11 enzyme is implicated in microRNA (miRNA) regulation. It can uridylate let-7 precursors to decrease quantities of the mature miRNA in embryonic stem cell lines, suggested to mediate stem cell maintenance. It can ...
    • ZDHHC7-Mediated S-Palmitoylation of Scribble Regulates Cell Polarity 

      Chen, Baoen; Zheng, Baohui; DeRan, Micael; Jarugumilli, Gopala K.; Fu, Jianjun; Brooks, Yang S.; Wu, Xu (2016)
      Scribble (SCRIB) is a tumor suppressor protein, playing critical roles in establishing and maintaining epithelial cell polarity. Paradoxically, SCRIB is frequently amplified in human cancers, however, fails to localize ...
    • Zebrafish behavioral profiling identifies multi-target antipsychotic-like compounds 

      Bruni, Giancarlo; Rennekamp, Andrew J.; Velenich, Andrea; McCarroll, Matthew; Gendelev, Leo; Fertsch, Ethan; Taylor, Jack; Lakhani, Parth; Lensen, Dennis; Evron, Tama; Lorello, Paul J.; Huang, Xi-Ping; Kolczewski, Sabine; Carey, Galen; Caldarone, Barbara J.; Prinssen, Eric; Roth, Bryan L.; Keiser, Michael J.; Peterson, Randall T.; Kokel, David (2016)
      Many psychiatric drugs act on multiple targets and therefore require screening assays that encompass a wide target space. With sufficiently rich phenotyping, and a large sampling of compounds, it should be possible to ...
    • A zebrafish model of conditional targeted podocyte ablation and regeneration 

      Huang, Jianmin; Mckee, Mary; Huang, Hong Dong; Xiang, Alice; Davidson, Alan J; Lu, Hua A J (2013)
      Podocytes are specialized cells that contribute critically to the normal structure and function of the glomerular filtration barrier. Their depletion plays an important role in the pathogenesis of glomerulosclerosis. Here, ...
    • Zebrafish models of cerebrovascular disease 

      Walcott, Brian P; Peterson, Randall T (Nature Publishing Group, 2014)
      Perturbations in cerebral blood flow and abnormalities in blood vessel structure are the hallmarks of cerebrovascular disease. While there are many genetic and environmental factors that affect these entities through a ...
    • Zebrafish orthologs of human muscular dystrophy genes 

      Steffen, Leta S; Guyon, Jeffrey R; Vogel, Emily D; Beltre, Rosanna; Pusack, Timothy J; Zhou, Yi; Zon, Leonard Ira; Kunkel, Louis Martens (BioMed Central, 2007)
      Background: Human muscular dystrophies are a heterogeneous group of genetic disorders which cause decreased muscle strength and often result in premature death. There is no known cure for muscular dystrophy, nor have all ...
    • Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis 

      Storer, Narie Y.; White, Richard M.; Uong, Audrey; Price, Emily; Nielsen, G. Petur; Langenau, David M.; Zon, Leonard I. (Company of Biologists, 2013)
      Rhabdomyosarcoma is a pediatric malignancy thought to arise from the uncontrolled proliferation of myogenic cells. Here, we have generated models of rhabdomyosarcoma in the zebrafish by inducing oncogenic KRAS(G12D) ...
    • Zebrafish VEGF Receptors: A Guideline to Nomenclature 

      Bussmann, Jeroen; Lawson, Nathan; Zon, Leonard Ira; Schulte-Merker, Stefan; Zebrafish Nomenclature Committee (Public Library of Science, 2008)
    • zebraflash transgenic lines for in vivo bioluminescence imaging of stem cells and regeneration in adult zebrafish 

      Chen, Chen-Hui; Durand, Ellen; Wang, Jinhu; Zon, Leonard I.; Poss, Kenneth D. (Company of Biologists, 2013)
      The zebrafish has become a standard model system for stem cell and tissue regeneration research, based on powerful genetics, high tissue regenerative capacity and low maintenance costs. Yet, these studies can be challenged ...
    • The Zelnorm Epidemiologic Study (ZEST): A Cohort Study Evaluating Incidence of Abdominal and Pelvic Surgery Related to Tegaserod Treatment 

      Seeger, John; Quinn, Sherry; Earnest, David L; Lembo, Anthony J.; Kuo, Braden; Rivero, Elena; Walker, Alexander M. (BioMed Central, 2012)
      Background: Pre-marketing clinical studies of tegaserod suggested an increased risk of abdominal surgery, particularly cholecystectomy. We sought to quantify the association between tegaserod use and the occurrence of ...
    • Zfp322a Regulates Mouse ES Cell Pluripotency and Enhances Reprogramming Efficiency 

      Ma, Hui; Ng, Hui Min; Teh, Xiuwen; Li, Hu; Lee, Yun Hwa; Chong, Yew Mei; Loh, Yuin Han; Collins, James J.; Feng, Bo; Yang, Henry; Wu, Qiang (Public Library of Science, 2014)
      Embryonic stem (ES) cells derived from the inner cell mass (ICM) of blastocysts are characterised by their ability to self-renew and their potential to differentiate into many different cell types. Recent studies have shown ...
    • Zfp36l2 is required for self-renewal of early erythroid BFU-E progenitors 

      Zhang, Lingbo; Prak, Lina; Rayon-Estrada, Violeta; Thiru, Prathapan; Flygare, Johan; Lim, Bing; Lodish, Harvey F. (2013)
      Stem cells and progenitors in many lineages undergo self- renewing divisions, but the extracellular and intracellular proteins that regulate this process are largely unknown. Glucocorticoids stimulate red cell formation ...
    • Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome 

      Klase, Zachary A.; Khakhina, Svetlana; Schneider, Adriano De Bernardi; Callahan, Michael V.; Glasspool-Malone, Jill; Malone, Robert (Public Library of Science, 2016)
      The ongoing Zika virus epidemic in the Americas and the observed association with both fetal abnormalities (primary microcephaly) and adult autoimmune pathology (Guillain–Barré syndrome) has brought attention to this ...
    • Zika Virus: Medical Countermeasure Development Challenges 

      Malone, Robert W.; Homan, Jane; Callahan, Michael V.; Glasspool-Malone, Jill; Damodaran, Lambodhar; Schneider, Adriano De Bernardi; Zimler, Rebecca; Talton, James; Cobb, Ronald R.; Ruzic, Ivan; Smith-Gagen, Julie; Janies, Daniel; Wilson, James (Public Library of Science, 2016)
      Introduction: Reports of high rates of primary microcephaly and Guillain–Barré syndrome associated with Zika virus infection in French Polynesia and Brazil have raised concerns that the virus circulating in these regions ...
    • Zinc Finger Database (ZiFDB): A Repository for Information on C2H2 Zinc Fingers and Engineered Zinc-Finger Arrays 

      Fu, Fengli; Sander, Jeffry D; Maeder, Morgan; Thibodeau-Beganny, Stacey; Joung, Jae Keith; Dobbs, Drena; Miller, Leslie; Voytas, Daniel F. (Oxford University Press, 2009)
      Zinc fingers are the most abundant DNA-binding motifs encoded by eukaryotic genomes and one of the best understood DNA-recognition domains. Each zinc finger typically binds a 3-nt target sequence, and it is possible to ...
    • Zinc Finger Protein Zbtb20 Is Essential for Postnatal Survival and Glucose Homeostasis 

      Sutherland, Andrew R.; Zhang, Hai; Zhang, Ye; Michaud, Monia; Xie, Zhifang; Patti, Mary-Elizabeth; Grusby, Michael J.; Zhang, Weiping J. (American Society for Microbiology, 2009)
      Zbtb20 is a member of the POK family of proteins, which function primarily as transcriptional repressors via interactions mediated by their conserved C2H2 Kruppel type zinc finger and BTB/POZ domains. To define the function ...
    • Zinc Finger Targeter (ZiFiT): An Engineered Zinc Finger/Target Site Design Tool 

      Sander, Jeffry D; Zaback, Peter; Joung, Jae Keith; Voytas, Daniel F.; Dobbs, Drena (Oxford University Press, 2007)
      Zinc Finger Targeter (ZiFiT) is a simple and intuitive web-based tool that facilitates the design of zinc finger proteins (ZFPs) that can bind to specific DNA sequences. The current version of ZiFiT is based on a widely ...
    • Zinc-binding Domain of the Bacteriophage T7 DNA Primase Modulates Binding to the DNA Template 

      Lee, Seung-Joo; Zhu, Bin; Akabayov, Barak; Richardson, Charles (American Society for Biochemistry and Molecular Biology, 2012)
      The zinc-binding domain (ZBD) of prokaryotic DNA primases has been postulated to be crucial for recognition of specific sequences in the single-stranded DNA template. To determine the molecular basis for this role in ...
    • Zinc-induced Alzheimer's Aβ1–40 Aggregation Is Mediated by Conformational Factors 

      Atwood, Craig S.; Hartshorn, Mariana A.; Vonsattel, Jean-Paul; Huang, Xudong; Moir, Robert; Tanzi, Rudolph; Bush, Ashley (American Society for Biochemistry & Molecular Biology (ASBMB), 1997-10-17)
      The heterogeneous precipitates of Aβ that accumulate in the brain cortex in Alzheimer's disease possess varying degrees of resistance to resolubilization. We previously found that Aβ1–40 is rapidly precipitated in vitro ...
    • Zoledronic Acid Enhances Lipopolysaccharide-Stimulated Proinflammatory Reactions through Controlled Expression of SOCS1 in Macrophages 

      Muratsu, Daichi; Yoshiga, Daigo; Taketomi, Takaharu; Onimura, Tomohiro; Seki, Yoshihiro; Matsumoto, Akinobu; Nakamura, Seiji (Public Library of Science, 2013)
      Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious side effect of nitrogen-containing bisphosphonate (NBP) use. Many studies have shown that BRONJ is limited to the jawbone and does not occur in the other ...