Now showing items 65-84 of 15907

    • An ABC Transporter Is Required for Secretion of Peptide Sex Pheromones in Enterococcus faecalis 

      Varahan, Sriram; Harms, Nathan; Gilmore, Michael S.; Tomich, John M.; Hancock, Lynn E. (American Society of Microbiology, 2014)
      ABSTRACT Enterococci are leading causes of hospital-acquired infection in the United States and continue to develop resistances to new antibiotics. Many Enterococcus faecalis isolates harbor pheromone-responsive plasmids ...
    • ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: A comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas 

      Johnatty, Sharon E.; Beesley, Jonathan; Gao, Bo; Chen, Xiaoqing; Lu, Yi; Law, Matthew H.; Henderson, Michelle J.; Russell, Amanda J.; Hedditch, Ellen L.; Emmanuel, Catherine; Fereday, Sian; Webb, Penelope M.; Goode, Ellen L.; Vierkant, Robert A.; Fridley, Brooke L.; Cunningham, Julie M; Fasching, Peter A.; Beckmann, Matthias W.; Ekici, Arif B.; Hogdall, Estrid; Kjaer, Susanne K.; Jensen, Allan; Hogdall, Claus; Brown, Robert; Paul, Jim; Lambrechts, Sandrina; Despierre, Evelyn; Vergote, Ignace; Lester, Jenny; Karlan, Beth Y.; Heitz, Florian; du Bois, Andreas; Harter, Philipp; Schwaab, Ira; Bean, Yukie; Pejovic, Tanja; Levine, Douglas A.; Goodman, Marc T.; Camey, Michael E.; Thompson, Pamela J.; Lurie, Galina; Shildkraut, Joellen; Berchuck, Andrew; Terry, Kathryn Lynne; Cramer, Daniel William; Norris, Murray D.; Haber, Michelle; MacGregor, Stuart; deFazio, Anna; Chenevix-Trench, Georgia (Elsevier BV, 2013)
      Objective ABCB1 encodes the multi-drug efflux pump P-glycoprotein (P-gp) and has been implicated in multi-drug resistance. We comprehensively evaluated this gene and flanking regions for an association with clinical ...
    • Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria 

      Chen, Wen; Paradkar, P. N.; Li, L.; Pierce, E. L.; Langer, N. B.; Takahashi-Makise, N.; Hyde, B. B.; Shirihai, O. S.; Ward, D. M.; Kaplan, J.; Paw, Barry Htin (Proceedings of the National Academy of Sciences, 2009)
      Mitoferrin-1 (Mfrn1; Slc25a37), a member of the solute carrier family localized in the mitochondrial inner membrane, functions as an essential iron importer for the synthesis of mitochondrial heme and iron–sulfur clusters ...
    • abd-A Regulation by the iab-8 Noncoding RNA 

      Gummalla, Maheshwar; Maeda, Robert K.; Castro Alvarez, Javier J.; Gyurkovics, Henrik; Singari, Swetha; Edwards, Kevin A.; Karch, François; Bender, Welcome W. (Public Library of Science, 2012)
      The homeotic genes in Drosophila melanogaster are aligned on the chromosome in the order of the body segments that they affect. The genes affecting the more posterior segments repress the more anterior genes. This posterior ...
    • Abdominal Cross-sectional Imaging for Inpatients With Abnormal Liver Function Test Results 

      Rothschild, Jeffrey Mark; Khorasani, Ramin; Silverman, Stuart George; Hanson, Richard; Fiskio, Julie M.; Bates, David Westfall (American Medical Association (AMA), 2001)
      Background: Abdominal cross-sectional imaging is often performed to evaluate abnormal liver function test (LFT) results in hospitalized patients. However, few data are available regarding the yield and usefulness of imaging ...
    • Abdominal obesity and hyperglycemia mask the effect of a common APOC3 haplotype on the risk of myocardial infarction 

      Ruiz-Narváez, Edward; Sacks, Frank Martin; Campos, Hannia (American Society for Nutrition, 2008)
      Background Plasma apolipoprotein (apo) C-III strongly predicts myocardial infarction (MI) and directly activates atherogenic processes invascularcells.Geneticvariationintheinsulinresponseelementofthe APOC3 promoter is ...
    • Abdominal Pain, the Adolescent and Altered Brain Structure and Function 

      Hubbard, Catherine S.; Becerra, Lino; Heinz, Nicole; Ludwick, Allison; Rasooly, Tali; Wu, Rina; Johnson, Adriana; Schechter, Neil L.; Borsook, David; Nurko, Samuel (Public Library of Science, 2016)
      Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder of unknown etiology. Although relatively common in children, how this condition affects brain structure and function in a pediatric population ...
    • Abdominal Subcutaneous Adipose Tissue: A Protective Fat Depot? 

      Porter, Stacy Ann; Massaro, Joseph M.; Hoffmann, Udo; Vasan, Ramachandran S.; O'Donnel, Christopher J.; Fox, Caroline (American Diabetes Association, 2009)
      OBJECTIVE: Obesity is associated with increased metabolic and cardiovascular risk. The ectopic fat hypothesis suggests that subcutaneous fat may be protective, but this theory has yet to be fully explored. RESEARCH DESIGN ...
    • Abdominal Superficial Subcutaneous Fat 

      Golan, Rachel; Shelef, Ilan; Rudich, Assaf; Gepner, Yftach; Shemesh, Elad; Chassidim, Yoash; Harman-Boehm, Ilana; Henkin, Yaakov; Schwarzfuchs, Dan; Ben Avraham, Sivan; Witkow, Shula; Liberty, Idit F.; Tangi-Rosental, Osnat; Sarusi, Benjamin; Stampfer, Meir Jonathan; Shai, Iris (American Diabetes Association, 2012)
      OBJECTIVE: Unlike visceral adipose tissue (VAT), the association between subcutaneous adipose tissue (SAT) and obesity-related morbidity is controversial. In patients with type 2 diabetes, we assessed whether this variability ...
    • Abelson Phosphorylation of CLASP2 Modulates its Association With Microtubules and Actin 

      Engel, Ulrike; Zhan, Yougen; Long, Jennifer B; Boyle, Scott N; Ballif, Bryan A; Dorey, Karel; Gygi, Steven P; Koleske, Anthony J; VanVactor, David (Blackwell Publishing Ltd, 2014)
      The Abelson (Abl) non-receptor tyrosine kinase regulates the cytoskeleton during multiple stages of neural development, from neurulation, to the articulation of axons and dendrites, to synapse formation and maintenance. ...
    • Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β 

      Kim, Man Lyang; Chae, Jae Jin; Park, Yong Hwan; De Nardo, Dominic; Stirzaker, Roslynn A.; Ko, Hyun-Ja; Tye, Hazel; Cengia, Louise; DiRago, Ladina; Metcalf, Donald; Roberts, Andrew W.; Kastner, Daniel L.; Lew, Andrew M.; Lyras, Dena; Kile, Benjamin T.; Croker, Ben A.; Masters, Seth L. (The Rockefeller University Press, 2015)
      Gain-of-function mutations that activate the innate immune system can cause systemic autoinflammatory diseases associated with increased IL-1β production. This cytokine is activated identically to IL-18 by an intracellular ...
    • Aberrant Brain Plasticity in Autism Spectrum Disorders 

      Oberman, Lindsay M.; Rotenberg, Alexander; Pascual-Leone, Alvaro (Oxford University Press, 2014)
      Plasticity enables the human brain to adapt to developmental challenges and rapidly changing environmental demands, acquire new skills, and cope with injury. However, aberrant or mistimed brain plasticity can lead to ...
    • Aberrant error processing in relation to symptom severity in obsessive–compulsive disorder: A multimodal neuroimaging study 

      Agam, Yigal; Greenberg, Jennifer L.; Isom, Marlisa; Falkenstein, Martha J.; Jenike, Eric; Wilhelm, Sabine; Manoach, Dara S. (Elsevier, 2014)
      Background: Obsessive–compulsive disorder (OCD) is characterized by maladaptive repetitive behaviors that persist despite feedback. Using multimodal neuroimaging, we tested the hypothesis that this behavioral rigidity ...
    • Aberrant Expression of Functional BAFF-System Receptors by Malignant B-Cell Precursors Impacts Leukemia Cell Survival 

      Maia, Sara; Pelletier, Marc; Ding, Jixin; Hsu, Yen-Ming; Sallan, Stephen Earl; Rao, Sambasiva P.; Nadler, Lee Marshall; Cardoso, Angelo A. (Public Library of Science, 2011)
      Despite exhibiting oncogenic events, patient's leukemia cells are responsive and dependent on signals from their malignant bone marrow (BM) microenvironment, which modulate their survival, cell cycle progression, trafficking ...
    • Aberrant regulation of FBW7 in cancer 

      Wang, Lixia; Ye, Xiantao; Liu, Yueyong; Wei, Wenyi; Wang, Zhiwei (Impact Journals LLC, 2014)
      FBW7 (F-box and WD repeat domain-containing 7) or Fbxw7 is a tumor suppressor, which promotes the ubiquitination and subsequent degradation of numerous oncoproteins including Mcl-1, Cyclin E, Notch, c- Jun, and c-Myc. In ...
    • Aberrant semantic activation in schizophrenia: a neurophysiological study 

      Nestor, PG; Kimble, MO; O'Donnell, BF; Smith, L; Niznikiewicz, Margaret A.; Shenton, Martha Elizabeth; McCarley, RW (American Psychiatric Publishing, 1997)
      OBJECTIVE: Schizophrenia has long been thought to be characterized by a fundamental disturbance in semantic associations, which has often been presumed to be of neurobiological origin. The authors examined the neurophysiological ...
    • The Ability of Flux Balance Analysis to Predict Evolution of Central Metabolism Scales with the Initial Distance to the Optimum 

      Harcombe, William R.; Delaney, Nigel F.; Leiby, Nicholas; Klitgord, Niels; Marx, Christopher J. (Public Library of Science, 2013)
      The most powerful genome-scale framework to model metabolism, flux balance analysis (FBA), is an evolutionary optimality model. It hypothesizes selection upon a proposed optimality criterion in order to predict the set of ...
    • Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes 

      Mann, Jaclyn K; Byakwaga, Helen; Kuang, Xiaomei T; Le, Anh Q; Brumme, Chanson J; Mwimanzi, Philip; Omarjee, Saleha; Martin, Eric; Lee, Guinevere Q; Baraki, Bemuluyigza; Danroth, Ryan; McCloskey, Rosemary; Muzoora, Conrad; Bangsberg, David R; Hunt, Peter W; Goulder, Philip JR; Walker, Bruce D; Harrigan, P Richard; Martin, Jeff N; Ndung’u, Thumbi; Brockman, Mark A; Brumme, Zabrina L (BioMed Central, 2013)
      Background: The highly genetically diverse HIV-1 group M subtypes may differ in their biological properties. Nef is an important mediator of viral pathogenicity; however, to date, a comprehensive inter-subtype comparison ...
    • Ablation of AMP-Activated Protein Kinase \(\alpha\)2 Activity Exacerbates Insulin Resistance Induced by High-Fat Feeding of Mice 

      Fujii, Nobuharu; Ho, Richard C.; Manabe, Yasuko; Jessen, Niels; Toyoda, Taro; Holland, William; Summers, Scott A.; Hirshman, Michael F.; Goodyear, Laurie Joy (American Diabetes Association, 2008)
      Objective: We determined whether muscle AMP-activated protein kinase (AMPK) has a role in the development of insulin resistance. Research Design and Methods: Muscle-specific transgenic mice expressing an inactive form of ...
    • Ablation of SGK1 Impairs Endothelial Cell Migration and Tube Formation Leading to Decreased Neo-Angiogenesis Following Myocardial Infarction 

      Zarrinpashneh, Elham; Poggioli, Tommaso; Sarathchandra, Padmini; Lexow, Jonas; Monassier, Laurent; Terracciano, Cesare; Lang, Florian; Damilano, Federico; Zhou, Jessica Q.; Rosenzweig, Anthony; Rosenthal, Nadia; Santini, Maria Paola (Public Library of Science, 2013)
      Serum and glucocorticoid inducible kinase 1 (SGK1) plays a pivotal role in early angiogenesis during embryonic development. In this study, we sought to define the SGK1 downstream signalling pathways in the adult heart and ...