Now showing items 7515-7534 of 18423

    • H+ Transport Is an Integral Function of the Mitochondrial ADP/ATP Carrier 

      Vidoni, Sara; Bertholet, Ambre; Chouchani, Edward; Kazak, Lawrence; Angelin, Alessia; Fedorenko, Andriy; Long, Jonathan; Garrity, Ryan; Cho, Joonseok; Terada, Naohiro; Wallace, Douglas; Spiegelman, Bruce; Kirichok, Yurly (Springer Science and Business Media LLC, 2019-07)
      The mitochondrial ADP/ATP carrier (AAC) is a major transport protein of the inner mitochondrial membrane. It exchanges mitochondrial ATP for cytosolic ADP and controls cellular production of ATP. In addition, it has been ...
    • H2A.Z Landscapes and Dual Modifications in Pluripotent and Multipotent Stem Cells Underlie Complex Genome Regulatory Functions 

      Ku, Manching; Jaffe, Jacob D; Koche, Richard P; Rheinbay, Esther; Endoh, Mitsuhiro; Koseki, Haruhiko; Carr, Steven A; Bernstein, Bradley E (BioMed Central, 2012)
      Background: The histone variant H2A.Z has been implicated in nucleosome exchange, transcriptional activation and Polycomb repression. However, the relationships among these seemingly disparate functions remain obscure. ...
    • H2O2-responsive molecularly engineered polymer nanoparticles as ischemia/reperfusion-targeted nanotherapeutic agents 

      Lee, Dongwon; Bae, Soochan; Hong, Donghyun; Lim, Hyungsuk; Yoon, Joo Heung; Hwang, On; Park, Seunggyu; Ke, Qingen; Khang, Gilson; Kang, Peter M. (Nature Publishing Group, 2013)
      The main culprit in the pathogenesis of ischemia/reperfusion (I/R) injury is the overproduction of reactive oxygen species (ROS). Hydrogen peroxide (H2O2), the most abundant form of ROS produced during I/R, causes inflammation, ...
    • H3K36 methylation maintains cell identity by regulating opposing lineage programmes 

      Hoetker, Michael; Yagi, Masaki; Di Stefano, Bruno; Langerman, Justin; Cristea, Simona; Wong, Lai Ping; Huebner, Aaron J; Charlton, Jocelyn; Deng, Weixian; Haggerty, Chuck; Sadreyev, Ruslan I; Meissner, Alexander; Michor, Franziska; Plath, Kathrin; Hochedlinger, Konrad (Springer Science and Business Media LLC, 2023-07-17)
      The epigenetic mechanisms that maintain differentiated cell states remain largely unexplored. Here, we employed histone mutants to uncover a crucial role for H3K36-methylation in the maintenance of cell identities across ...
    • H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression 

      Rowbotham, Samuel; Li, F.; Dost, Antonella; Louie, Sharon M.; Marsh, B. P.; Pessina, Patrizia; Anbarasu, C. R.; Brainson, C. F.; Tuminello, S. J.; Lieberman, A.; Ryeom, S.; Schlaeger, Thorsten; Aronow, B. J.; Watanabe, H.; Wong, K. K.; Kim, Carla (Springer Science and Business Media LLC, 2018-11-19)
      Epigenetic regulators are attractive anticancer targets, but the promise of therapeutic strategies inhibiting some of these factors has not been proven in vivo or taken into account tumor cell heterogeneity. Here we show ...
    • Habitual intake of anthocyanins and flavanones and risk of cardiovascular disease in men12 

      Cassidy, Aedín; Bertoia, Monica; Chiuve, Stephanie; Flint, Alan; Forman, John; Rimm, Eric B (American Society for Nutrition, 2016)
      Background: Although increased fruit intake reduces cardiovascular disease (CVD) risk, which fruits are most beneficial and what key constituents are responsible are unclear. Habitual intakes of flavonoids, specifically ...
    • Habitual intake of flavonoid subclasses and risk of colorectal cancer in 2 large prospective cohorts12 

      Nimptsch, Katharina; Zhang, Xuehong; Cassidy, Aedín; Song, Mingyang; O’Reilly, Éilis J; Lin, Jennifer H; Pischon, Tobias; Rimm, Eric B; Willett, Walter C; Fuchs, Charles S; Ogino, Shuji; Chan, Andrew T; Giovannucci, Edward L; Wu, Kana (American Society for Nutrition, 2016)
      Background: Flavonoids inhibit the growth of colon cancer cells in vitro. In a secondary analysis of a randomized controlled trial, the Polyp Prevention Trial, a higher intake of one subclass, flavonols, was statistically ...
    • The HAC1 Gene from Pichia Pastoris: Characterization and Effect of its Overexpression on the Production of Secreted, Surface Displayed and Membrane Proteins 

      Guerfal, Mouna; Ryckaert, Stefan; Jacobs, Pieter P.; Ameloot, Paul; Van Craenenbroeck, Kathleen; Derycke, Riet; Callewaert, Nico (BioMed Central, 2010)
      Background: The unfolded protein response (UPR) in eukaryotes upregulates factors that restore ER homeostasis upon protein folding stress and in yeast is activated by a non-conventional splicing of the HAC1 mRNA. The spliced ...
    • Haematological Safety of Perinatal Zidovudine in Pregnant HIV-1–Infected Women in Thailand: Secondary Analysis of a Randomized Trial 

      Briand, Nelly; Lallemant, Marc Jean; Jourdain, Gonzague Joseph Albert; Techapalokul, Somnuek; Tunthanathip, Preecha; Suphanich, Surachet; Chanpoo, Truengta; Traisathit, Patrinee; McIntosh, Kenneth; Coeur, Sophie Le (Public Library of Science, 2007)
      Objectives: To respond to the primary safety objective of the Perinatal HIV Prevention Trial 1 (PHPT-1) by studying the evolution of haematological parameters according to zidovudine exposure duration in HIV-1−infected ...
    • Haematopoietic stem cells require a highly regulated protein synthesis rate 

      Signer, Robert A.J.; Magee, Jeffrey A.; Salic, Adrian; Morrison, Sean J. (2014)
      Many aspects of cellular physiology remain unstudied in somatic stem cells. For example, there are almost no data on protein synthesis in any somatic stem cell. We found that the amount of protein synthesized per hour in ...
    • Hair follicle melanocyte cells as a renewable source of melanocytes for culture and transplantation 

      Kwon, Ho-Keun; Liu, Perry H.; Lew, Dae-Hyun; Nishimura, Emi; Orgill, Dennis Paul (2008)
      Objective: Advances in melanocyte culture techniques have not yet led to reliable clinical methods for treating hypopigmentation disorders. We hypothesized that melanocytes harvested from plucked hair follicles may provide ...
    • Hair Manganese and Hyperactive Behaviors: Pilot Study of School-Age Children Exposed through Tap Water 

      Bouchard, Maryse; Laforest, François; Vandelac, Louise; Bellinger, David C.; Mergler, Donna (National Institute of Environmental Health Sciences, 2006)
      Background: Neurotoxic effects are known to occur with inhalation of manganese particulates, but very few data are available on exposure to Mn in water. We undertook a pilot study in a community in Québec (Canada) where ...
    • Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells 

      Lee, Jiyoon; Rabbani, Cyrus; Gao, Hongyu; Steinhart, Matthew; Woodruff, Benjamin M.; Pflum, Zachary; Kim, Alexander; Heller, Stefan; Liu, Yunlong; Shipchandler, Taha Z.; Koehler, Karl R.; Koehler (Springer Nature, 2019-07-31)
      The skin is a multi-layered organ equipped with appendages (i.e. follicles and glands) critical for regulating bodily fluid retention and temperature, guarding against external stresses, and mediating touch and pain ...
    • Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice 

      Wu, Xudong; Indzhykulian, Artur A.; Niksch, Paul D.; Webber, Roxanna M.; Garcia-Gonzalez, Miguel; Watnick, Terry; Zhou, Jing; Vollrath, Melissa A.; Corey, David P. (Public Library of Science, 2016)
      Members of the TRP superfamily of ion channels mediate mechanosensation in some organisms, and have been suggested as candidates for the mechanotransduction channel in vertebrate hair cells. Some TRP channels can be ruled ...
    • The Haiti Breast Cancer Initiative: Initial Findings and Analysis of Barriers-to-Care Delaying Patient Presentation 

      Sharma, Ketan; Costas, Ainhoa; Damuse, Ruth; Hamiltong-Pierre, Jean; Pyda, Jordan; Ong, Cecilia T.; Shulman, Lawrence N.; Meara, John G. (Hindawi Publishing Corporation, 2013)
      Background. In Haiti, breast cancer patients present at such advanced stages that even modern therapies offer modest survival benefit. Identifying the personal, sociocultural, and economic barriers-to-care delaying patient ...
    • Haiti’s progress in achieving its 10-year plan to eliminate cholera: hidden sickness cannot be cured 

      Koski-Karell, Victoria; Farmer, Paul E; Isaac, Benito; Campa, Elizabeth M; Viaud, Loune; Namphy, Paul C; Ternier, Ralph; Ivers, Louise C (Dove Medical Press, 2016)
      Since the beginning of the cholera epidemic in Haiti 5 years ago, the prevalence of this deadly water-borne disease has fallen far below the initial rates registered during its explosive outset. However, cholera continues ...
    • Hallux valgus and plantar pressure loading: the Framingham foot study 

      Galica, Andrew M; Hagedorn, Thomas J; Dufour, Alyssa B; Riskowski, Jody L; Hillstrom, Howard J; Casey, Virginia A; Hannan, Marian T (BioMed Central, 2013)
      Background: Hallux valgus (HV), a common structural foot deformity, can cause foot pain and lead to limited mobility. The purpose of this study was to evaluate differences in plantar pressure and force during gait by HV ...
    • Handling changes in MRI acquisition parameters in modeling whole brain lesion volume and atrophy data in multiple sclerosis subjects: Comparison of linear mixed-effect models 

      Chua, Alicia S.; Egorova, Svetlana; Anderson, Mark C.; Polgar-Turcsanyi, Mariann; Chitnis, Tanuja; Weiner, Howard L.; Guttmann, Charles R.G.; Bakshi, Rohit; Healy, Brian C. (Elsevier, 2015)
      Magnetic resonance imaging (MRI) of the brain provides important outcome measures in the longitudinal evaluation of disease activity and progression in MS subjects. Two common measures derived from brain MRI scans are the ...
    • Handling incomplete correlated continuous and binary outcomes in meta‐analysis of individual participant data 

      Gomes, Manuel; Hatfield, Laura; Normand, Sharon‐Lise (John Wiley and Sons Inc., 2016)
      Meta‐analysis of individual participant data (IPD) is increasingly utilised to improve the estimation of treatment effects, particularly among different participant subgroups. An important concern in IPD meta‐analysis ...
    • Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence 

      Sedic, Maja; Skibinski, Adam; Brown, Nelson; Gallardo, Mercedes; Mulligan, Peter; Martinez, Paula; Keller, Patricia J.; Glover, Eugene; Richardson, Andrea L.; Cowan, Janet; Toland, Amanda E.; Ravichandran, Krithika; Riethman, Harold; Naber, Stephen P.; Näär, Anders M.; Blasco, Maria A.; Hinds, Philip W.; Kuperwasser, Charlotte (Nature Pub. Group, 2015)
      Although BRCA1 function is essential for maintaining genomic integrity in all cell types, it is unclear why increased risk of cancer in individuals harbouring deleterious mutations in BRCA1 is restricted to only a select ...