Browsing Harvard Medical School by Title
Now showing items 12193-12212 of 18423
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O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway
(2016)Tumors utilize aerobic glycolysis to support growth and invasion. However, the molecular mechanisms that link metabolism with invasion are not well understood. The nutrient sensor O-linked-β-N-acetylglucosamine (O-GlcNAc) ... -
O-Glycosylation Regulates Ubiquitination and Degradation of the Anti-Inflammatory Protein A20 to Accelerate Atherosclerosis in Diabetic ApoE-Null Mice
(Public Library of Science, 2010)Background: Accelerated atherosclerosis is the leading cause of morbidity and mortality in diabetic patients. Hyperglycemia is a recognized independent risk factor for heightened atherogenesis in diabetes mellitus (DM). ... -
O-Specific Polysaccharide-Specific Memory B Cell Responses in Young Children, Older Children, and Adults Infected with Vibrio cholerae O1 Ogawa in Bangladesh
(American Society for Microbiology, 2016)Cholera caused by Vibrio cholerae O1 confers at least 3 to 10 years of protection against subsequent disease regardless of age, despite a relatively rapid fall in antibody levels in peripheral blood, suggesting that memory ... -
OA011-05. TLR-mediated pDC responses to HIV-1 ligands
(BioMed Central, 2009) -
OA031-04. Impairment of HIV-1-specific CD8+ T cell function by soluble epithelial adhesion molecules
(BioMed Central, 2009) -
OA08.04. Brain circuitry subserving acupuncture relief of itch in atopic dermatitis: an fMRI study
(BioMed Central, 2012) -
OA11.02. A model of integrative care for low back pain
(BioMed Central, 2012) -
OASIS is Automated Statistical Inference for Segmentation, with applications to multiple sclerosis lesion segmentation in MRI☆
(Elsevier, 2013)Magnetic resonance imaging (MRI) can be used to detect lesions in the brains of multiple sclerosis (MS) patients and is essential for diagnosing the disease and monitoring its progression. In practice, lesion load is often ... -
Obesity & Hypertension are Determinants of Poor Hemodynamic Control during Total Joint Arthroplasty: A Retrospective Review
(BioMed Central, 2013)Background: Proper blood pressure control during surgical procedures such as total joint arthroplasty (TJA) is considered critical to good outcome. There is poor understanding of the pre-operative risk factors for poor ... -
Obesity and Breastfeeding: Exploring the Relationship
(Mary Ann Liebert Inc, 2016)Obesity has reached epidemic proportions in the United States and throughout much of the developing world. In the United States, 40.4% of women, 35% of men, and 17% of children and adolescents have obesity. With the high ... -
Obesity and Mortality, Length of Stay and Hospital Cost among Patients with Sepsis: A Nationwide Inpatient Retrospective Cohort Study
(Public Library of Science, 2016)Objectives: The objective of this study was to examine the association between obesity and all-cause mortality, length of stay and hospital cost among patients with sepsis 20 years of age or older. Materials and Methods ... -
Obesity and risk of ovarian cancer subtypes: evidence from the Ovarian Cancer Association Consortium
(BioScientifica, 2013)Whilst previous studies have reported that higher body-mass index (BMI) increases a woman’s risk of developing ovarian cancer, associations for the different histological subtypes have not been well defined. As the prevalence ... -
Obesity and the Odds of Weight Gain following Androgen Deprivation Therapy for Prostate Cancer
(Hindawi Publishing Corporation, 2014)Background:. Increasing body mass index (BMI) is associated with increased risk of mortality; however, quantifying weight gain in men undergoing androgen deprivation therapy (ADT) for prostate cancer (PC) remains unexplored. ... -
Obesity and Type 2 Diabetes: What Can Be Unified and What Needs to Be Individualized?
(American Diabetes Association, 2011)Objective: This report examines what is known about the relationship between obesity and type 2 diabetes and how future research in these areas might be directed to benefit prevention, interventions, and overall patient ... -
Obesity and undiagnosed diabetes in the U.S.
(American Diabetes Association, 2008)OBJECTIVE—To study whether obese individuals, who are at higher risk for diabetes and disparities in care than nonobese individuals, are more likely to have undiagnosed diabetes. RESEARCH DESIGN AND METHODS—We performed ... -
Obesity as a risk factor for severe influenza-like illness
(Blackwell Publishing Ltd, 2013)Background: Obesity was recognized as in independent risk factor for influenza during the 2009 H1N1 influenza pandemic. Objectives: We evaluated the association between body mass index (BMI) and influenza-like illness (ILI) ...