Browsing Harvard Medical School by Title
Now showing items 2142-2161 of 15907
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Characterization of the Filum terminale as a neural progenitor cell niche in both rats and humans
(John Wiley and Sons Inc., 2016)Abstract Neural stem cells (NSCs) reside in a unique microenvironment within the central nervous system (CNS) called the NSC niche. Although they are relatively rare, niches have been previously characterized in both the ... -
Characterization of the integrated filamentous phage Pf5 and its involvement in small-colony formation
(Society for General Microbiology, 2007)Bacteriophages play an important role in bacterial virulence and phenotypic variation. It has been shown that filamentous bacteriophage Pf4 of Pseudomonas aeruginosa strain PAO1 mediates the formation of small-colony ... -
Characterization of the MUC1-C Cytoplasmic Domain as a Cancer Target
(Public Library of Science, 2015)Mucin 1 (MUC1) is a heterodimeric protein that is aberrantly expressed in diverse human carcinomas and certain hematologic malignancies. The oncogenic MUC1 transmembrane C-terminal subunit (MUC1-C) functions in part by ... -
Characterization of the Mutagenic Spectrum of 4-Nitroquinoline 1-Oxide (4-NQO) in Aspergillus nidulans by Whole Genome Sequencing
(Genetics Society of America, 2014)4-Nitroquinoline 1-oxide (4-NQO) is a highly carcinogenic chemical that induces mutations in bacteria, fungi, and animals through the formation of bulky purine adducts. 4-NQO has been used as a mutagen for genetic screens ... -
Characterization of the RpoN Regulon Reveals Differential Regulation of T6SS and New Flagellar Operons in Vibrio cholerae O37 Strain V52
(Oxford University Press, 2012)The alternative sigma factor RpoN is an essential colonization factor of Vibrio cholerae and controls important cellular functions including motility and type VI secretion (T6SS). The RpoN regulon has yet to be clearly ... -
Characterization of the Spatiotemporal Network in Prefrontal Cortex-Hippocampal Synchronization: The Role of the Thalamic Nucleus Reuniens and Delta Band 2-5 Hz Oscillations
(2017-05-12)Background: Schizophrenia is a devastating mental health illness in which our pharmacologic options do not treat the cognitive deficits that largely contribute to long-term disability. Problems with cognition likely arise ... -
Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours
(Nature Pub. Group, 2015)Currently available human tumour cell line panels consist of a small number of lines in each lineage that generally fail to retain the phenotype of the original patient tumour. Here we develop a cell culture medium that ... -
Characterization of two distinct early post-entry blocks to HIV-1 in common marmoset lymphocytes
(Nature Publishing Group, 2016)In nature, primate lentiviruses infect humans and several Old World monkeys and apes. However, to date, lentiviruses infecting New World monkeys have not been described. We studied the susceptibility of common marmoset ... -
Characterization of Two Distinct Lymphoproliferative Diseases Caused by Ectopic Expression of the Notch Ligand DLL4 on T Cells
(Public Library of Science, 2013)Notch signaling is essential for the development of T cell progenitors through the interaction of NOTCH1 receptor on their surface with the ligand, Delta-like 4 (DLL4), which is expressed by the thymic epithelial cells. ... -
Characterization of Vascular Disease Risk in Postmenopausal Women and Its Association with Cognitive Performance
(Public Library of Science, 2013)Objectives: While global measures of cardiovascular (CV) risk are used to guide prevention and treatment decisions, these estimates fail to account for the considerable interindividual variability in pre-clinical risk ... -
Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth.
(American Society for Clinical Investigation, 1996)Vascular endothelial growth factor (VEGF) is a potent endothelial cell mitogen which mediates its effects by binding to tyrosine kinase receptors. We have characterized the VEGF-activated intracellular signal transduction ... -
Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases
(Portland Press Ltd., 2014)The related NUAK1 and NUAK2 are members of the AMPK (AMP-activated protein kinase) family of protein kinases that are activated by the LKB1 (liver kinase B1) tumour suppressor kinase. Recent work suggests they play important ... -
Characterizing Acupuncture Stimuli Using Brain Imaging with fMRI - A Systematic Review and Meta-Analysis of the Literature
(Public Library of Science (PLoS), 2012)Background The mechanisms of action underlying acupuncture, including acupuncture point specificity, are not well understood. In the previous decade, an increasing number of studies have applied fMRI to investigate brain ... -
Characterizing and Modulating Brain Circuitry through Transcranial Magnetic Stimulation Combined with Electroencephalography
(Frontiers Media S.A., 2016)The concurrent combination of transcranial magnetic stimulation (TMS) with electroencephalography (TMS-EEG) is a powerful technology for characterizing and modulating brain networks across developmental, behavioral, and ... -
Characterizing EEG Brain States During General Anesthesia in Children: Insights for Improved Brain Monitoring
(2016-05-17)Current brain monitors in clinical anesthesia use electroencephalography (EEG) based single indices (patient state indices, PSIs) as a biomarker for level of unconsciousness. These values range from zero (isoelectric) to ... -
Characterizing genomic alterations in cancer by complementary functional associations
(2016)Systematic efforts to sequence the cancer genome have identified large numbers of relevant mutations and copy number alterations in human cancers; however, elucidating their functional consequences, and their interactions ... -
Characterizing heterogeneity in leukemic cells using single-cell gene expression analysis
(BioMed Central, 2014)Background: A fundamental challenge for cancer therapy is that each tumor contains a highly heterogeneous cell population whose structure and mechanistic underpinnings remain incompletely understood. Recent advances in ... -
Characterizing Sympathetic Neurovascular Transduction in Humans
(Public Library of Science, 2013)Despite its critical role for cardiovascular homeostasis in humans, only a few studies have directly probed the transduction of sympathetic nerve activity to regional vascular responses – sympathetic neurovascular transduction. ... -
Characterizing the DNA Damage Response by Cell Tracking Algorithms and Cell Features Classification Using High-Content Time-Lapse Analysis
(Public Library of Science, 2015)Traditionally, the kinetics of DNA repair have been estimated using immunocytochemistry by labeling proteins involved in the DNA damage response (DDR) with fluorescent markers in a fixed cell assay. However, detailed ... -
Characterizing the limited use of point-of-care ultrasound in Colombian emergency medicine residencies
(Springer, 2014)Background: Emergency medicine (EM) is a growing specialty in Colombia with five residency programs in the country. EM leadership is interested in incorporating point-of-care (POC) ultrasound into a standardized national ...