Browsing Harvard Medical School by Title
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Plasma Phospholipid Trans‐Fatty Acids Levels, Cardiovascular Diseases, and Total Mortality: The Cardiovascular Health Study
(Blackwell Publishing Ltd, 2014)Background: While self‐reported trans–fatty acid (TFA) consumption is linked to coronary heart disease (CHD), relationships between objective biomarkers of TFA subtypes (t‐16:1n9, total t‐18:1, and cis/trans‐(c/t‐), t/c‐ ... -
Plasma S100β is not a useful biomarker for tumor burden in neurofibromatosis
(Elsevier BV, 2013)Objectives Neurofibromatosis 1 (NF1), NF2, and schwannomatosis are characterized by a predisposition to develop multiple neurofibromas and schwannomas. Currently, there is no blood test to estimate tumor burden in ... -
Plasma Soluble VEGFR-1 Is a Potential Dual Biomarker of Response and Toxicity for Bevacizumab with Chemoradiation in Locally Advanced Rectal Cancer
(Alphamed Press, 2010)We explored plasma and urinary concentrations of two members of the vascular endothelial growth factor (VEGF) family and their receptors as potential response and toxicity biomarkers of bevacizumab with neoadjuvant ... -
Plasma Vitamin D Levels, Menopause, and Risk of Breast Cancer: Dose-Response Meta-Analysis of Prospective Studies
(Wolters Kluwer Health, 2013)Abstract Previous evidence suggests that higher circulating 25-hydroxyvitamin D (25[OH]D) levels are variably associated with lower breast cancer risk; however, prospective studies and clinical trials have been inconsistent, ... -
Plasma-type gelsolin in subarachnoid hemorrhage: novel biomarker today, therapeutic target tomorrow?
(BioMed Central, 2014)There is growing interest in the potential neuroprotective properties of gelsolin. In particular, plasma-type gelsolin (pGSN) can ameliorate deleterious inflammatory response by scavenging pro-inflammatory signals such as ... -
Plasmablastic Lymphoma: A Systematic Review
(Hindawi Limited, 2011-03-22)Plasmablastic lymphoma (PBL) is a very aggressive variant of diffuse large B-cell lymphoma initially described in the oral cavity of HIV-infected individuals. PBL represents a diagnostic challenge given its characteristic ... -
Plasmacytoma of the Clivus Presenting as Bilateral Sixth Nerve Palsy
(Georg Thieme Verlag KG, 2015)Background and Importance Plasmacytomas are monoclonal proliferations of plasma cells that may arise within soft tissue or bone. The skull base is a rare site for plasmacytomas to occur, and few cases have been reported ... -
Plasmodium falciparum gene expression measured directly from tissue during human infection
(BioMed Central, 2014)Background: During the latter half of the natural 48-h intraerythrocytic life cycle of human Plasmodium falciparum infection, parasites sequester deep in endothelium of tissues, away from the spleen and inaccessible to ... -
Plastic Surgery Training Worldwide: Part 1. The United States and Europe
(Wolters Kluwer Health, 2016)Background: Major differences exist in residency training, and the structure and quality of residency programs differ between different countries and teaching centers. It is of vital importance that a better understanding ... -
Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2
(2015)Absent in melanoma 2 (AIM2) is an essential cytosolic double-stranded DNA receptor that assembles with the adaptor, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and caspase-1 to ... -
Plasticity of brain wave network interactions and evolution across physiologic states
(Frontiers Media S.A., 2015)Neural plasticity transcends a range of spatio-temporal scales and serves as the basis of various brain activities and physiologic functions. At the microscopic level, it enables the emergence of brain waves with complex ... -
Plasticity of face processing in infancy
(Proceedings of the National Academy of Sciences, 2005)Experience plays a crucial role for the normal development of many perceptual and cognitive functions, such as speech perception. For example, between 6 and 10 months of age, the infant's ability to discriminate among ... -
Platelet actin nodules are podosome-like structures dependent on Wiskott–Aldrich syndrome protein and ARP2/3 complex
(Nature Pub. Group, 2015)The actin nodule is a novel F-actin structure present in platelets during early spreading. However, only limited detail is known regarding nodule organization and function. Here we use electron microscopy, SIM and dSTORM ... -
Platelet Granule Exocytosis: A Comparison with Chromaffin Cells
(Frontiers Media S.A., 2013)The rapid secretion of bioactive amines from chromaffin cells constitutes an important component of the fight or flight response of mammals to stress. Platelets respond to stresses within the vasculature by rapidly secreting ... -
Platelet-Associated CD40/CD154 Mediates Remote Tissue Damage after Mesenteric Ischemia/Reperfusion Injury
(Public Library of Science, 2012)Several innate and adaptive immune cell types participate in ischemia/reperfusion induced tissue injury. Amongst them, platelets have received little attention as contributors in the process of tissue damage after ischemia ... -
Platelet-Derived Growth Factor Receptor β Is Critical for Zebrafish Intersegmental Vessel Formation
(Public Library of Science, 2010)Background: Platelet-derived growth factor receptor β (PDGFRβ) is a tyrosine kinase receptor known to affect vascular development. The zebrafish is an excellent model to study specific regulators of vascular development, ... -
Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage
(National Academy of Sciences, 2006)Platelets contain both pro- and antiangiogenic factors, but their regulatory role in angiogenesis is poorly understood. Although previous studies showed that platelets stimulate angiogenesis in vitro, the role of platelets ... -
Platelets Generated from Human Embryonic Stem Cells are Functional In Vitro and in the Microcirculation of Living Mice
(Nature Publishing Group, 2011)Platelets play an essential role in hemostasis and atherothrombosis. Owing to their short storage time, there is constant demand for this life-saving blood component. In this study, we report that it is feasible to generate ... -
Platelets Recognize Brain-Specific Glycolipid Structures, Respond to Neurovascular Damage and Promote Neuroinflammation
(Public Library of Science, 2013)Platelets respond to vascular damage and contribute to inflammation, but their role in the neurodegenerative diseases is unknown. We found that the systemic administration of brain lipid rafts induced a massive platelet ... -
Platform dependence of inference on gene-wise and gene-set involvement in human lung development
(BioMed Central, 2009)Background: With the recent development of microarray technologies, the comparability of gene expression data obtained from different platforms poses an important problem. We evaluated two widely used platforms, Affymetrix ...