Browsing Harvard Medical School by Title
Now showing items 1362-1381 of 18428
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Asthma Self-assessment in a Medicaid Population
(BioMed Central, 2009)Background: Self-assessment of symptoms by patients with chronic conditions is an important element of disease management. A recent study in a commercially-insured population found that patients who received automated ... -
Asthma Treatments and Mental Health Visits After a Food and Drug Administration Label Change for Leukotriene Inhibitors
(Elsevier BV, 2015)Purpose In 2009, the US Food and Drug Administration (FDA) mandated a label change for leukotriene inhibitors (LTIs) to include neuropsychiatric adverse events (eg, depression and suicidality) as a precaution. This study ... -
Asthma-susceptibility variants identified using probands in case-control and family-based analyses
(BioMed Central, 2010)Background: Asthma is a chronic respiratory disease whose genetic basis has been explored for over two decades, most recently via genome-wide association studies. We sought to find asthma-susceptibility variants by using ... -
Astrocyte regulation of sleep circuits: experimental and modeling perspectives
(Frontiers Media S.A., 2012)Integrated within neural circuits, astrocytes have recently been shown to modulate brain rhythms thought to mediate sleep function. Experimental evidence suggests that local impact of astrocytes on single synapses translates ... -
Astrocyte-Specific Disruption of SynCAM1 Signaling Results in ADHD-Like Behavioral Manifestations
(Public Library of Science, 2012)SynCAM1 is an adhesion molecule involved in synaptic differentiation and organization. SynCAM1 is also expressed in astroglial cells where it mediates astrocyte-to astrocyte and glial-neuronal adhesive communication. In ... -
Astrocytes in the optic nerve head express putative mechanosensitive channels
(Molecular Vision, 2015)Purpose To establish whether optic nerve head astrocytes express candidate molecules to sense tissue stretch. Methods: We used conventional PCR, quantitative PCR, and single-cell reverse transcription PCR (RT–PCR) to assess ... -
Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways
(2014)To achieve its precise neural connectivity, the developing mammalian nervous system undergoes extensive activity-dependent synapse remodeling. Recently microglial cells have been shown to be responsible for a portion of ... -
Astrocytes refine cortical connectivity at dendritic spines
(eLife Sciences Publications, Ltd, 2014)During cortical synaptic development, thalamic axons must establish synaptic connections despite the presence of the more abundant intracortical projections. How thalamocortical synapses are formed and maintained in this ... -
The ASTUTE Health study protocol: Deliberative stakeholder engagements to inform implementation approaches to healthcare disinvestment
(BioMed Central, 2012)Background: Governments and other payers are yet to determine optimal processes by which to review the safety, effectiveness, and cost-effectiveness of technologies and procedures that are in active use within health ... -
Asymmetric division coordinates collective cell migration in angiogenesis
(Springer Science and Business Media LLC, 2016-11-21)The asymmetric division of stem or progenitor cells generates daughters with distinct fates and regulates cell diversity during tissue morphogenesis1. However, roles for asymmetric division in other more dynamic morphogenetic ... -
Asymmetric formation of coated pits on dorsal and ventral surfaces at the leading edges of motile cells and on protrusions of immobile cells
(The American Society for Cell Biology, 2015)Clathrin/AP2-coated vesicles are the principal endocytic carriers originating at the plasma membrane. In the experiments reported here, we used spinning-disk confocal and lattice light-sheet microscopy to study the assembly ... -
Asymmetric neurotransmitter release enables rapid odor lateralization in Drosophila
(2012)In Drosophila, most individual olfactory receptor neurons (ORNs) project bilaterally to both sides of the brain1,2. Having bilateral rather than unilateral projections may represent a useful redundancy. However, bilateral ... -
Asymmetric Processing of Human Immunodeficiency Virus Type 1 cDNA in Vivo: Implications for Functional End Coupling during the Chemical Steps of DNA Transposition
(American Society for Microbiology, 2001) -
Asymmetric projections of the arcuate fasciculus to the temporal cortex underlie lateralized language function in the human brain
(Frontiers Media S.A., 2015)The arcuate fasciculus (AF) in the human brain has asymmetric structural properties. However, the topographic organization of the asymmetric AF projections to the cortex and its relevance to cortical function remain unclear. ... -
Asymmetric Requirement of Surface Epithelial β-Catenin During the Upper and Lower Jaw Development
(Wiley-Liss, Inc., 2012)Background: Intercellular communication between epithelial and mesenchymal cells is central to mammalian craniofacial development. β-catenin is the gateway of canonical Wnt signaling, one of the major evolutionarily conserved ... -
Asymmetry in facial expression
(American Association for the Advancement of Science (AAAS), 1980) -
Asymptomatic Extracranial Artery Stenosis and the Risk of Cardiovascular and Cerebrovascular Diseases
(Nature Publishing Group, 2016)Asymptomatic extracranial artery stenosis (ECAS) is a well-known risk factor for stroke events, but it remains unclear whether it has the same role in predicting cardiovascular and cerebrovascular diseases, especially in ... -
Asymptomatic Polyvascular Abnormalities in Community (APAC) Study in China: Objectives, Design and Baseline Characteristics
(Public Library of Science, 2013)Objective: The population-based “Asymptomatic Polyvascular Abnormalities in Community (APAC) Study was designed to examine prevalence and associations of asymptomatic polyvascular abnormalities (APA) in a general population. ... -
AT-RvD1 Modulates CCL-2 and CXCL-8 Production and NF-κB, STAT-6, SOCS1, and SOCS3 Expression on Bronchial Epithelial Cells Stimulated with IL-4
(Hindawi Publishing Corporation, 2015)Bronchial epithelial cells represent the first line of defense against microorganisms and allergens in the airways and play an important role in chronic inflammatory processes such as asthma. In an experimental model, both ...