Browsing Harvard Medical School by Title

Now showing items 14166-14185 of 18428

    • Quantitative Investigation of the Effect of the Extra-Cerebral Vasculature in Diffuse Optical Imaging: A Simulation Study 

      Dehaes, Mathieu; Gagnon, Louis; Lesage, Frederic; Pelegrini-Issac, Melanie; Vignaud, Alexandre; Valabregue, Romain; Grebe, Reinhard; Wallois, Fabrice; Benali, Habib (Optical Society of America, 2011)
      Diffuse optical imaging (DOI) is a non invasive technique allowing the recovery of hemodynamic changes in the brain. Due to the diffusive nature of photon propagation in turbid media and the fact that cerebral tissues are ...

    • The Quantitative Methods Boot Camp: Teaching Quantitative Thinking and Computing Skills to Graduate Students in the Life Sciences 

      Stefan, Melanie I.; Gutlerner, Johanna L.; Born, Richard T.; Springer, Michael (Public Library of Science, 2015)
      The past decade has seen a rapid increase in the ability of biologists to collect large amounts of data. It is therefore vital that research biologists acquire the necessary skills during their training to visualize, ...

    • Quantitative Methods for Molecular Diagnostic and Therapeutic Imaging 

      Li, Quanzheng (Ivyspring International Publisher, 2013)
      This theme issue provides an overview on the basic quantitative methods, an in-depth discussion on the cutting-edge quantitative analysis approaches as well as their applications for both static and dynamic molecular ...

    • Quantitative Molecular Assessment of Chimerism across Tissues in Marmosets and Tamarins 

      Sweeney, Carolyn G; Curran, Elizabeth H.; Westmoreland, Susan V.; Mansfield, Keith G.; Vallender, Eric (BioMed Central, 2012)
      Background: Marmosets are playing an increasingly large and important role in biomedical research. They share genetic, anatomical, and physiological similarities with humans and other primate model species, but their smaller ...

    • Quantitative Morphological Signatures Define Local Signaling Networks Regulating Cell Morphology 

      Bakal, C.; Aach, J.; Church, G.; Perrimon, N. (American Association for the Advancement of Science, 2007)
      Although classical genetic and biochemical approaches have identified hundreds of proteins that function in the dynamic remodeling of cell shape in response to upstream signals, there is currently little systems-level ...

    • A quantitative MR measure of the fornix in schizophrenia 

      Zahajszky, Janos; Dickey, Chandlee C.; McCarley, Robert William; Fischer, Iris A.; Nestor, Paul Gerard; Kikinis, Ron; Shenton, Martha Elizabeth (Elsevier BV, 2001)
      Some cognitive disturbances accompanying schizophrenia may be due to abnormalities in the thalamus and components of the limbic system. The fornix is an important white-matter relay pathway connecting these structures and ...

    • Quantitative MRI Phenotypes in Longitudinal Population of MS Patients. 

      Egorova, Svetlana; Polgar-Turcsanyi, Mariann; Anderson, Mark Allen; Healy, Brian Curran; Weiner, Howard Lee (2014)

    • Quantitative MRI study of Pineal Gland in MS. 

      Egorova, Svetlana; Denes, Palma; Polgar-Turcsanyi, Mariann; Anderson, Mark Allen; Cavallari, Michele; Guttmann, Charles R.G.; Glanz, Bonnie; Chitnis, Tanuja; Bove, Riley; Buckle, Guy; De Jager, Philip Lawrence; Severson, Cristopher; Stankiewicz, James; Houtchens, Maria K.; Quintana, Francisco Javier; Gandhi, Roopali; Webb, Pia; Meier, Dominik; Healy, Brian Curran; Weiner, Howard Lee (2016)

    • Quantitative Oxygen Extraction Fraction from 7-Tesla MRI Phase: Reproducibility and Application in Multiple Sclerosis 

      Fan, Audrey P.; Govindarajan, Sindhuja T.; Kinkel, R. Phillip; Madigan, Nancy K.; Nielsen, A. Scott; Benner, Thomas; Tinelli, Emanuele; Rosen, Bruce; Adalsteinsson, Elfar; Mainero, Caterina (SAGE Publications, 2014-10-29)
      Quantitative oxygen extraction fraction (OEF) in cortical veins was studied in patients with multiple sclerosis (MS) and healthy subjects via magnetic resonance imaging (MRI) phase images at 7 Tesla (7 T). Flow-compensated, ...

    • Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips 

      Herland, Anna; Maoz, Ben M.; Das, Debarun; Somayaji, Mahadevabharath R.; Prantil-Baun, Rachelle; Novak, Richard; Cronce, Michael; Huffstater, Tessa; Jeanty, Sauveur S.F.; Ingram, Miles; Chalkiadaki, Angeliki; Chou, David; Clauson, Susan; Delahanty, Aaron; Jalili-Firoozinezhad, Sasan; Milton, Yuka; Sontheimer-Phelps, Alexandra; Swenor, Ben; Levy, Oren; Parker, Kevin K.; Przekwas, Andrzej; Ingber, Donald (Springer Science and Business Media LLC, 2020-01-27)
      Analyses of drug pharmacokinetics (PKs) and pharmacodynamics (PDs) performed in animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD modelling does not provide quantitative PK parameters. ...

    • Quantitative Profiling of Peptides from RNAs classified as non-coding 

      Prabakaran, Sudhakaran; Hemberg, Martin; Chauhan, Ruchi; Winter, Dominic; Tweedie-Cullen, Ry Y.; Dittrich, Christian; Hong, Elizabeth; Gunawardena, Jeremy; Steen, Hanno; Kreiman, Gabriel; Steen, Judith A. (2014)
      Only a small fraction of the mammalian genome codes for messenger RNAs destined to be translated into proteins, and it is generally assumed that a large portion of transcribed sequences - including introns and several ...

    • Quantitative proteomic analysis in HCV-induced HCC reveals sets of proteins with potential significance for racial disparity 

      Dillon, Simon T; Bhasin, Manoj K; Feng, Xiaoxing; Koh, David W; Daoud, Sayed S (BioMed Central, 2013)
      Background: The incidence and mortality of hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) is higher in African Americans (AA) than other racial/ethnic groups in the U.S., but the reasons for this disparity ...

    • Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy 

      Mancias, Joseph D.; Wang, Xiaoxu; Gygi, Steven P.; Harper, J. Wade; Kimmelman, Alec C. (2014)
      Autophagy, the process by which proteins and organelles are sequestered in double-membrane structures called autophagosomes and delivered to lysosomes for degradation, is critical in diseases such as cancer and ...

    • Quantitative Proteomics of an Amphibian Pathogen, Batrachochytrium dendrobatidis, following Exposure to Thyroid Hormone 

      Thekkiniath, Jose; Zabet-Moghaddam, Masoud; Kottapalli, Kameswara Rao; Pasham, Mithun R.; San Francisco, Susan; San Francisco, Michael (Public Library of Science, 2015)
      Batrachochytrium dendrobatidis (Bd), a chytrid fungus, has increasingly been implicated as a major factor in the worldwide decline of amphibian populations. The fungus causes chytridiomycosis in susceptible species leading ...

    • Quantitative rates of brain glucose metabolism distinguish minimally conscious from vegetative state patients 

      Stender, Johan; Kupers, Ron; Rodell, Anders; Thibaut, Aurore; Chatelle, Camille; Bruno, Marie-Aurélie; Gejl, Michael; Bernard, Claire; Hustinx, Roland; Laureys, Steven; Gjedde, Albert (Nature Publishing Group, 2015)
      The differentiation of the vegetative or unresponsive wakefulness syndrome (VS/UWS) from the minimally conscious state (MCS) is an important clinical issue. The cerebral metabolic rate of glucose (CMRglc) declines when ...

    • Quantitative Statistical Methods for Image Quality Assessment 

      Dutta, Joyita; Ahn, Sangtae; Li, Quanzheng (Ivyspring International Publisher, 2013)
      Quantitative measures of image quality and reliability are critical for both qualitative interpretation and quantitative analysis of medical images. While, in theory, it is possible to analyze reconstructed images by means ...

    • Quantitative Super-Resolution Imaging with qPAINT using Transient Binding Analysis 

      Jungmann, Ralf; Avendaño, Maier S; Dai, Mingjie; Woehrstein, Johannes B; Agasti, Sarit S; Feiger, Zachary; Rodal, Avital; Yin, Peng (2016)
      Current super-resolution techniques offer unprecedented spatial resolution, but quantitative counting of spatially unresolvable molecules remains challenging. Here, we use the programmable and specific binding of dye-labeled ...

    • A Quantitative Systems View of the Spindle Assembly Checkpoint 

      Ciliberto, Andrea; Shah, Jagesh V. (Nature Publishing Group, 2009)
      The idle assembly checkpoint acts to delay chromosome segregation until all duplicated sister chromatids are captured by the mitotic spindle. This pathway ensures that each daughter cell receives a complete copy of the ...

    • A quantitative theory of immediate visual recognition 

      Serre, Thomas; Kreiman, Gabriel; Kouh, Minjoon; Cadieu, Charles; Knoblich, Ulf; Poggio, Tomaso (Elsevier BV, 2007)
      Human and non-human primates excel at visual recognition tasks. The primate visual system exhibits a strong degree of selectivity while at the same time being robust to changes in the input image. We have developed a ...

    • Quantitative Trait Locus and Brain Expression of HLA-DPA1 Offers Evidence of Shared Immune Alterations in Psychiatric Disorders 

      Morgan, Ling Z.; Rollins, Brandi; Sequeira, Adolfo; Byerley, William; DeLisi, Lynn E.; Schatzberg, Alan F.; Barchas, Jack D.; Myers, Richard M.; Watson, Stanley J.; Akil, Huda; Bunney, William E.; Vawter, Marquis P. (2016)
      Genome-wide association studies of schizophrenia encompassing the major histocompatibility locus (MHC) were highly significant following genome-wide correction. This broad region implicates many genes including the MHC ...