Browsing Harvard Medical School by Title

Now showing items 15932-15951 of 18428

    • SnapShot-Seq: A Method for Extracting Genome-Wide, In Vivo mRNA Dynamics from a Single Total RNA Sample 

      Gray, Jesse M.; Harmin, David A.; Boswell, Sarah A.; Cloonan, Nicole; Mullen, Thomas E.; Ling, Joseph J.; Miller, Nimrod; Kuersten, Scott; Ma, Yong-Chao; McCarroll, Steven A.; Grimmond, Sean M.; Springer, Michael (Public Library of Science, 2014)
      mRNA synthesis, processing, and destruction involve a complex series of molecular steps that are incompletely understood. Because the RNA intermediates in each of these steps have finite lifetimes, extensive mechanistic ...

    • SNF8, a member of the ESCRT-II complex, interacts with TRPC6 and enhances its channel activity 

      Carrasquillo, Robert; Tian, Dequan; Krishna, Sneha; Pollak, Martin Russell; Greka, Anna; Schlöndorff, Johannes (BioMed Central, 2012)
      Background: Transient receptor potential canonical (TRPC) channels are non-selective cation channels involved in receptor-mediated calcium signaling in diverse cells and tissues. The canonical transient receptor potential ...

    • SNP genotyping allows an in-depth characterisation of the genome of sugarcane and other complex autopolyploids 

      Garcia, Antonio A. F.; Mollinari, Marcelo; Marconi, Thiago G.; Serang, Oliver R.; Silva, Renato R.; Vieira, Maria L. C.; Vicentini, Renato; Costa, Estela A.; Mancini, Melina C.; Garcia, Melissa O. S.; Pastina, Maria M.; Gazaffi, Rodrigo; Martins, Eliana R. F.; Dahmer, Nair; Sforça, Danilo A.; Silva, Claudio B. C.; Bundock, Peter; Henry, Robert J.; Souza, Glaucia M.; van Sluys, Marie-Anne; Landell, Marcos G. A.; Carneiro, Monalisa S.; Vincentz, Michel A. G.; Pinto, Luciana R.; Vencovsky, Roland; Souza, Anete P. (Nature Publishing Group, 2013)
      Many plant species of great economic value (e.g., potato, wheat, cotton, and sugarcane) are polyploids. Despite the essential roles of autopolyploid plants in human activities, our genetic understanding of these species ...

    • SNP panel identification assay (SPIA): a genetic-based assay for the identification of cell lines 

      Demichelis, Francesca; Greulich, Heidi E.; Macoska, Jill A.; Beroukhim, Rameen; Sellers, William R.; Garraway, Levi Alexander; Rubin, Mark A. (Oxford University Press, 2008)
      Translational research hinges on the ability to make observations in model systems and to implement those findings into clinical applications, such as the development of diagnostic tools or targeted therapeutics. Tumor ...

    • SNP rs1533428 at 2p16.3 as a marker for late-onset primary open-angle glaucoma 

      Tam, Pancy O.S.; Leung, Dexter Y.L.; Fan, Alex H.; Zhang, Mingzhi; Tham, Clement C.Y.; Wang, Ningli; Pang, Chi Pui; Chen, Li Jia; Fan, Baojian; Chiang, Sylvia W.Y. (Molecular Vision, 2012)
      Purpose: To investigate the associations between gene variants in cholesterol 24S-hydroxylase (CYP46A1), LIM homeobox transcription factor 1-beta (LMX1B), plexin domain containing 2 (PLXDC2), toll-like receptor 4 (TLR4), ...

    • SNPExpress: Integrated Visualization of Genome-wide Genotypes, Copy Numbers and Gene Expression Levels 

      Sanders, Mathijs A; Verhaak, Roel; Geertsma-Kleinekoort, Wendy MC; Abbas, Saman; Horsman, Sebastiaan; van der Spek, Peter J; Löwenberg, Bob; Valk, Peter JM (BioMed Central, 2008)
      Background: Accurate analyses of comprehensive genome-wide SNP genotyping and gene expression data sets is challenging for many researchers. In fact, obtaining an integrated view of both large scale SNP genotyping and gene ...

    • SNPsea: an algorithm to identify cell types, tissues and pathways affected by risk loci 

      Slowikowski, Kamil; Hu, Xinli; Raychaudhuri, Soumya (Oxford University Press, 2014)
      Summary: We created a fast, robust and general C++ implementation of a single-nucleotide polymorphism (SNP) set enrichment algorithm to identify cell types, tissues and pathways affected by risk loci. It tests trait-associated ...

    • Snx3 Regulates Recycling of the Transferrin Receptor and Iron Assimilation 

      Chen, Caiyong; Garcia-Santos, Daniel; Ishikawa, Yuichi; Seguin, Alexandra; Li, Liangtao; Fegan, Katherine H.; Hildick-Smith, Gordon J.; Shah, Darshan Anil; Cooney, James A.; Chen, Wen; King, Michael; Yien, Yvette Yee; Schultz, Iman J.; Anderson, Heidi; Dalton, Abigail Goodnow; Freedman, Matthew Lawrence; Kingsley, Paul D.; Palis, James; Hattangadi, Shilpa M.; Lodish, Harvey F.; Ward, Daniel Alexander; Kaplan, Jerry B.; Maeda, Takahiro; Ponka, Prem; Paw, Barry Htin (Elsevier BV, 2013)
      Sorting of endocytic ligands and receptors is critical for diverse cellular processes. The physiological significance of endosomal sorting proteins in vertebrates, however, remains largely unknown. Here we report that ...

    • Social Activity and Cognitive Functioning Over Time: A Coordinated Analysis of Four Longitudinal Studies 

      Brown, Cassandra L.; Gibbons, Laura E.; Kennison, Robert F.; Robitaille, Annie; Lindwall, Magnus; Mitchell, Meghan B.; Shirk, Steven D.; Atri, Alireza; Cimino, Cynthia R.; Benitez, Andreana; MacDonald, Stuart W. S.; Zelinski, Elizabeth M.; Willis, Sherry L.; Schaie, K. Warner; Johansson, Boo; Dixon, Roger A.; Mungas, Dan M.; Hofer, Scott M.; Piccinin, Andrea M. (Hindawi Publishing Corporation, 2012)
      Social activity is typically viewed as part of an engaged lifestyle that may help mitigate the deleterious effects of advanced age on cognitive function. As such, social activity has been examined in relation to cognitive ...

    • Social and Cultural Features of Cholera and Shigellosis in Peri-Urban and Rural Communities of Zanzibar 

      Schaetti, Christian; Khatib, Ahmed M; Ali, Said M; Hutubessy, Raymond; Chaignat, Claire-Lise; Weiss, Mitchell (BMC, 2010-11-26)
      Background Responding to the high burden of cholera in developing countries, the WHO now considers vaccination as a supplement to the provision of safe drinking water and improved sanitation in the strategy for cholera ...

    • Social and Economic Consequences of Overweight in Adolescence and Young Adulthood 

      Gortmaker, Steven L.; Must, Aviva; Perrin, James Marc; Sobol, Arthur Martin; Dietz, William H. (New England Journal of Medicine (NEJM/MMS), 1993)

    • Social Capital and Health: A Review of Prospective Multilevel Studies 

      Murayama, Hiroshi; Fujiwara, Yoshinori; Kawachi, Ichiro (Japan Epidemiological Association, 2012)
      Background: This article presents an overview of the concept of social capital, reviews prospective multilevel analytic studies of the association between social capital and health, and discusses intervention strategies ...

    • Social Capital and Health: Does Egalitarianism Matter? A Literature Review 

      Merlo, Juan; Lindström, Martin; Gerdtham, Ulf-G; Islam, M. Kamrul; Kawachi, Ichiro (BioMed Central, 2006)
      The aim of the paper is to critically review the notion of social capital and review empirical literature on the association between social capital and health across countries. The methodology used for the review includes ...

    • Social Capital and Self-Rated Health Among Adolescents in Brazil: An Exploratory Study 

      Borges, Carolina M.; Campos, Ana Cristina V; Vargas, Andrea D; Ferreira, Efigênia F; Kawachi, Ichiro (BioMed Central, 2010)
      Background: Social capital may influence health and the patterns of association differ according its dimension such as cognitive, behavioral, bridging or bonding. There is a few numbers of studies in Latin America which ...

    • Social Context in Developmental Psychopathology: Recommendations for Future Research from the MacArthur Network on Psychopathology and Development 

      Boyce, W. Thomas; Frank, Ellen; Jensen, Peter S.; Kessler, Ronald; Nelson, Charles A.; Steinberg, Laurence (Cambridge University Press (CUP), 1998)
      Accumulating evidence suggests that social contexts in early life have important and complex effects on childhood psychopathology. Spurred by the lack of an explicit operational definition that could guide the study of ...

    • The Social Ecology of Cervical Cancer: The Challenges to Pap Smear Screening 

      Goodman, Annekathryn (Scientific Research Publishing, Inc,, 2013)
      Cervical cancer is a preventable disease. The risk factors for the development of cervical cancer include both biologic factors and social factors. In the United States, the leading risk factor for the development of ...

    • Social Ecology of Children’s Vulnerability to Environmental Pollutants 

      Weiss, Bernard; Bellinger, David C. (National Institute of Environmental Health Sciences, 2006)
      Background: The outcomes of exposure to neurotoxic chemicals early in life depend on the properties of both the chemical and the host’s environment. When our questions focus on the toxicant, the environmental properties ...

    • Social Encoding in the Medial Prefrontal Cortex 

      Friedman, Gabriel (2018-05-15)
      Social dysfunction is among the most prominent features of autism spectrum disorder (ASD). Despite a growing understanding of its genetic and micro-anatomic underpinnings, little is known about how ASD influences the ...

    • Social Epidemiology of Undocumented Ebola Virus Transmission in Liberia: An Explanatory Sequential Mixed-Methods Study 

      Wilson, Barthalomew (2021-06-25)
      Introduction: Despite the high number of EVD cases recorded during the 2013-2016 Ebola outbreak in West Africa, our understanding of Ebola virus disease (EVD) epidemiology remains limited. A significant gap in the knowledge ...

    • The Social Geography of American Medicine 

      Kim, David A. (2016-05-17)
      Health care exhibits wide geographic variation. Because care is driven by the behavior of physicians, regional differences in its cost and quality are thought to reflect local cultures of medical practice, but the mechanisms ...