Browsing Harvard Medical School by Title

Now showing items 16049-16068 of 18428

    • Spatial clustering of physical activity and obesity in relation to built environment factors among older women in three U.S. states 

      Tamura, Kosuke; Puett, Robin C; Hart, Jaime E; Starnes, Heather A; Laden, Francine; Troped, Philip J (BioMed Central, 2014)
      Background: Identifying spatial clusters of chronic diseases has been conducted over the past several decades. More recently these approaches have been applied to physical activity and obesity. However, few studies have ...

    • Spatial determinants of the alfalfa mosaic virus coat protein binding site 

      Laforest, Siana M.; Gehrke, Lee (Cold Spring Harbor Laboratory Press, 2004)
      The biological functions of RNA-protein complexes are, for the most part, poorly defined. Here, we describe experiments that are aimed at understanding the functional significance of alfalfa mosaic virus RNA-coat protein ...

    • Spatial Distribution of Cosmetic-Procedure Businesses in Two U.S. Cities: A Pilot Mapping and Validation Study 

      Austin, S. Bryn; Gordon, Allegra R.; Kennedy, Grace A.; Sonneville, Kendrin R.; Blossom, Jeffrey; Blood, Emily A. (MDPI, 2013)
      Cosmetic procedures have proliferated rapidly over the past few decades, with over $11 billion spent on cosmetic surgeries and other minimally invasive procedures and another $2.9 billion spent on U.V. indoor tanning in ...

    • Spatial Effects on the Speed and Reliability of Protein–DNA Search 

      Wunderlich, Zeba Batool; Mirny, Leonid Alex (Oxford University Press, 2008)
      Strong experimental and theoretical evidence shows that transcription factors (TFs) and other specific DNA-binding proteins find their sites using a two-mode search: alternating between three-dimensional (3D) diffusion ...

    • Spatial Frequency Discrimination in Schizophrenia 

      O, Brian F.; Potts, Geoffrey F.; Nestor, Paul Gerard; Stylianopoulos, Kiriaki C; Shenton, Martha Elizabeth; McCarley, Robert William (American Psychological Association (APA), 2002)
      Pathways within the visual system can be distinguished on the basis of selectivity for low or high spatial frequencies. Spatial frequency discrimination was evaluated in 17 medicated male patients with schizophrenia and ...

    • Spatial information in large-scale neural recordings 

      Cybulski, Thaddeus R.; Glaser, Joshua I.; Marblestone, Adam H.; Zamft, Bradley M.; Boyden, Edward S.; Church, George M.; Kording, Konrad P. (Frontiers Media S.A., 2015)
      To record from a given neuron, a recording technology must be able to separate the activity of that neuron from the activity of its neighbors. Here, we develop a Fisher information based framework to determine the conditions ...

    • Spatial normalization of diffusion tensor MRI using multiple channels 

      Park, Hae-Jeong; Kubicki, Marek R.; Shenton, Martha Elizabeth; Guimond, Alexandre; McCarley, Robert William; Maier, Stephan Ernst; Kikinis, Ron; Jolesz, Ferenc A.; Westin, Carl-Fredrik (Elsevier BV, 2003)
      Diffusion Tensor MRI (DT-MRI) can provide important in vivo information for the detection of brain abnormalities in diseases characterized by compromised neural connectivity. To quantify diffusion tensor abnormalities based ...

    • Spatial variability and reproducibility of GABA‐edited MEGA‐LASER 3D‐MRSI in the brain at 3 T 

      Hnilicová, Petra; Považan, Michal; Strasser, Bernhard; Andronesi, Ovidiu C.; Gajdošík, Martin; Dydak, Ulrike; Ukropec, Jozef; Dobrota, Dušan; Trattnig, Siegfried; Bogner, Wolfgang (John Wiley and Sons Inc., 2016)
      The reproducibility of gamma‐aminobutyric acid (GABA) quantification results, obtained with MRSI, was determined on a 3 T MR scanner in healthy adults. In this study, a spiral‐encoded, GABA‐edited, MEGA‐LASER MRSI sequence ...

    • Spatio-temporal dynamics and laterality effects of face inversion, feature presence and configuration, and face outline 

      Marinkovic, Ksenija; Courtney, Maureen G.; Witzel, Thomas; Dale, Anders M.; Halgren, Eric (Frontiers Media S.A., 2014)
      Although a crucial role of the fusiform gyrus (FG) in face processing has been demonstrated with a variety of methods, converging evidence suggests that face processing involves an interactive and overlapping processing ...

    • Spatio-temporal modeling of particulate air pollution in the conterminous United States using geographic and meteorological predictors 

      Yanosky, Jeff D; Paciorek, Christopher J; Laden, Francine; Hart, Jaime E; Puett, Robin C; Liao, Duanping; Suh, Helen H (BioMed Central, 2014)
      Background: Exposure to atmospheric particulate matter (PM) remains an important public health concern, although it remains difficult to quantify accurately across large geographic areas with sufficiently high spatial ...

    • Spatiotemporal Dynamics of Dexmedetomidine-Induced Electroencephalogram Oscillations 

      Akeju, Oluwaseun; Kim, Seong-Eun; Vazquez, Rafael; Rhee, James; Pavone, Kara J.; Hobbs, Lauren E.; Purdon, Patrick L.; Brown, Emery N. (Public Library of Science, 2016)
      An improved understanding of the neural correlates of altered arousal states is fundamental for precise brain state targeting in clinical settings. More specifically, electroencephalogram recordings are now increasingly ...

    • The Spatiotemporal Dynamics of Oscillatory Activity in Humans Across Micro, Meso, and Macro Scales 

      Borzello, Mia; Chu, Catherine Jean; Ebrahim, S; Eskandar, Emad; Golby, Alexandra Jacqueline; Madsen, Joseph Russell; Andersen, W; Lee, Jane; Doyle, W; Thesen, T; Cash, Sydney S. (2016-11-16)
      Brain activity is characterized by oscillatory activity that spans at least two orders of magnitude. Previous investigations of the spatiotemporal dynamics of this wide range of oscillatory behavior has led to the concept ...

    • Spatiotemporal exposure modeling of ambient erythemal ultraviolet radiation 

      VoPham, Trang; Hart, Jaime E.; Bertrand, Kimberly A.; Sun, Zhibin; Tamimi, Rulla M.; Laden, Francine (BioMed Central, 2016)
      Background: Ultraviolet B (UV-B) radiation plays a multifaceted role in human health, inducing DNA damage and representing the primary source of vitamin D for most humans; however, current U.S. UV exposure models are limited ...

    • Spatiotemporal prediction of fine particulate matter using high-resolution satellite images in the Southeastern US 2003–2011 

      Lee, Mihye; Schwartz, Joel David; Kloog, Itai; Chudnovsky, Alexandra; Lyapustin, Alexei; Wang, Yujie; Melly, Steven John; Coull, Brent Andrew; Koutrakis, Petros; Schwartz, Joel David (Nature Publishing Group, 2015)
      Numerous studies have demonstrated that fine particulate matter (PM2.5, particles smaller than 2.5 μm in aerodynamic diameter) is associated with adverse health outcomes. The use of ground monitoring stations of PM2.5 to ...

    • Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8 <sup>+</sup> T cells drive gastrointestinal acute graft-versus-host disease 

      Tkachev, Victor; Kaminski, James; Potter, E. Lake; Furlan, Scott N.; Yu, Alison; Hunt, Daniel J.; McGuckin, Connor; Zheng, Hengqi; Colonna, Lucrezia; Gerdemann, Ulrike; Carlson, Judith; Hoffman, Michelle; Olvera, Joe; English, Chris; Baldessari, Audrey; Panoskaltsis-Mortari, Angela; Watkins, Benjamin; Qayed, Muna; Suessmuth, Yvonne; Betz, Kayla; Bratrude, Brandi; Langston, Amelia; Horan, John T.; Ordovas-Montanes, Jose; Shalek, Alex K.; Blazar, Bruce R.; Roederer, Mario; Kean, Leslie S. (American Association for the Advancement of Science (AAAS), 2021-01-13)

    • Spatiotemporally resolved transcriptomics reveals the subcellular RNA kinetic landscape 

      Ren, Jingyi; Zhou, Haowen; Zeng, Hu; Wang, Connie Kangni; Huang, Jiahao; Qiu, Xiaojie; Sui, Xin; Li, Qiang; Wu, Xunwei; Lin, Zuwan; Lo, Jennifer A.; Maher, Kamal; He, Yichun; Tang, Xin; Lam, Judson; Chen, Hongyu; Li, Brian; Fisher, David E.; Liu, Jia; Wang, Xiao (Springer Science and Business Media LLC, 2023-04-10)
      <jats:title>Abstract</jats:title><jats:p>Spatiotemporal regulation of the cellular transcriptome is crucial for proper protein expression and cellular function. However, the intricate subcellular dynamics of RNA remain ...

    • SPCalc: A Web-based Calculator for Sample Size and Power Calculations in Micro-array Studies 

      Qiu, Weiliang; Lee, Mei-Ling Ting (Biomedical Informatics Publishing Group, 2006)
      Calculation of the appropriate sample size in planning microarray studies is important because sample collection can be expensive and time-consuming. Sample-size calculation is also a challenging issue for microarray studies ...

    • Spdef deletion rescues the crypt cell proliferation defect in conditional Gata6 null mouse small intestine 

      Aronson, Boaz E; Stapleton, Kelly A; Vissers, Laurens ATM; Stokhuijzen, Eva; Bruijnzeel, Hanneke; Krasinski, Stephen D (BioMed Central, 2014)
      Background: GATA transcription factors are essential for self-renewal of the small intestinal epithelium. Gata4 is expressed in the proximal 85% of small intestine while Gata6 is expressed throughout the length of small ...

    • SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination 

      Wilson, Nathan R.; Olm-Shipman, Adam J.; Acevedo, Diana S.; Palaniyandi, Kanagaraj; Hall, Everett G.; Kosa, Edina; Stumpff, Kelly M.; Smith, Guerin J.; Pitstick, Lenore; Liao, Eric C.; Bjork, Bryan C.; Czirok, Andras; Saadi, Irfan (Nature Publishing Group, 2016)
      Cranial neural crest cells (CNCCs) delaminate from embryonic neural folds and migrate to pharyngeal arches, which give rise to most mid-facial structures. CNCC dysfunction plays a prominent role in the etiology of orofacial ...

    • SPECIAL CONSIDERATIONS IN TOPICAL TREATMENTS FOR COMMON SKIN CONDITIONS IN SKIN OF COLOR 

      Chang, Yu-Feng (2023-05-03)
      The skin of color (SOC) population is composed of individuals with darker skin phototypes (Fitzpatrick skin type III-VI), often referred to as persons with Asian, African, Native American, Hispanic, Middle Eastern/Arab, ...