Browsing Harvard Medical School by Title

Now showing items 17984-18003 of 18428

    • Vagus nerve controls resolution and pro-resolving mediators of inflammation 

      Mirakaj, Valbona; Dalli, Jesmond; Granja, Tiago; Rosenberger, Peter; Serhan, Charles N. (The Rockefeller University Press, 2014)
      Resolution of inflammation is now recognized as a biosynthetically active process involving pro-resolving mediators. Here, we show in zymosan-initiated peritoneal inflammation that the vagus nerve regulates local expression ...

    • A Validated Smartphone-Based Assessment of Gait and Gait Variability in Parkinson’s Disease 

      Ellis, Robert J.; Ng, Yee Sien; Zhu, Shenggao; Tan, Dawn M.; Anderson, Boyd; Schlaug, Gottfried; Wang, Ye (Public Library of Science, 2015)
      Background: A well-established connection exists between increased gait variability and greater fall likelihood in Parkinson’s disease (PD); however, a portable, validated means of quantifying gait variability (and testing ...

    • Validating the Children’s Depression Inventory in the context of Rwanda 

      Binagwaho, Agnes; Fawzi, Mary C. Smith; Agbonyitor, Mawuena; Nsanzimana, Sabin; Karema, Corine; Remera, Eric; Mutabazi, Vincent; Shyirambere, Cyprien; Cyamatare, Patrick; Nutt, Cameron; Wagner, Claire; Condo, Jeanine; Misago, Nancy; Kayiteshonga, Yvonne (BioMed Central, 2016)
      Background: Depression is often co-morbid with chronic conditions, and when combined with HIV it can increase progression and reduce survival. A brief and accurate screening tool for depression among children living with ...

    • Validation and Calibration of a Computer Simulation Model of Pediatric HIV Infection 

      Ciaranello, Andrea L.; Morris, Bethany L.; Walensky, Rochelle P.; Weinstein, Milton C.; Ayaya, Samuel; Doherty, Kathleen; Leroy, Valeriane; Hou, Taige; Desmonde, Sophie; Lu, Zhigang; Noubary, Farzad; Patel, Kunjal; Ramirez-Avila, Lynn; Losina, Elena; Seage III, George R.; Freedberg, Kenneth A. (Public Library of Science, 2013)
      Background: Computer simulation models can project long-term patient outcomes and inform health policy. We internally validated and then calibrated a model of HIV disease in children before initiation of antiretroviral ...

    • Validation of a Consensus Method for Identifying Delirium from Hospital Records 

      Kuhn, Elvira; Du, Xinyi; McGrath, Keith; Coveney, Sarah; O'Regan, Niamh; Richardson, Sarah; Teodorczuk, Andrew; Allan, Louise; Wilson, Dan; Inouye, Sharon K.; MacLullich, Alasdair M. J.; Meagher, David; Brayne, Carol; Timmons, Suzanne; Davis, Daniel (Public Library of Science, 2014)
      Background: Delirium is increasingly considered to be an important determinant of trajectories of cognitive decline. Therefore, analyses of existing cohort studies measuring cognitive outcomes could benefit from methods ...

    • Validation of a DNA methylation reference panel for the estimation of nucleated cells types in cord blood 

      Cardenas, Andres; Allard, Catherine; Doyon, Myriam; Houseman, E. Andres; Bakulski, Kelly M.; Perron, Patrice; Bouchard, Luigi; Hivert, Marie-France (Taylor & Francis, 2016)
      ABSTRACT Cord blood is widely used as surrogate tissue in epigenome-wide association studies of prenatal conditions. Cell type composition variation across samples can be an important confounder of epigenome-wide association ...

    • Validation of a Molecular and Pathological Model for Five-Year Mortality Risk in Patients with Early Stage Lung Adenocarcinoma 

      Bueno, Raphael; Hughes, Elisha; Wagner, Susanne; Gutin, Alexander S.; Lanchbury, Jerry S.; Zheng, Yifan; Archer, Michael A.; Gustafson, Corinne; Jones, Joshua T.; Rushton, Kristen; Saam, Jennifer; Kim, Edward; Barberis, Massimo; Wistuba, Ignacio; Wenstrup, Richard J.; Wallace, William A.; Hartman, Anne-Renee; Harrison, David J. (Lippincott Williams & Wilkins, 2014)
      Introduction: The aim of this study was to validate a molecular expression signature [cell cycle progression (CCP) score] that identifies patients with a higher risk of cancer-related death after surgical resection of early ...

    • Validation of a risk prediction tool for coronary heart disease in middle-aged women 

      De Vito, Katerina M.; Baer, Heather J.; Dart, Hank; Chiuve, Stephanie E.; Rimm, Eric B.; Colditz, Graham A. (BioMed Central, 2015)
      Background: Health risk appraisal tools may be useful for identifying individuals who would benefit from lifestyle changes and increased surveillance. We evaluated the validity of the Your Disease Risk tool (YDR) for ...

    • Validation of a score tool for measurement of histological severity in juvenile dermatomyositis and association with clinical severity of disease 

      Varsani, Hemlata; Charman, Susan C; Li, Charles K; Marie, Suely K N; Amato, Anthony A; Banwell, Brenda; Bove, Kevin E; Corse, Andrea M; Emslie-Smith, Alison M; Jacques, Thomas S; Lundberg, Ingrid E; Minetti, Carlo; Nennesmo, Inger; Rushing, Elisabeth J; Sallum, Adriana M E; Sewry, Caroline; Pilkington, Clarissa A; Holton, Janice L; Wedderburn, Lucy R (BMJ Publishing Group, 2015)
      Objectives: To study muscle biopsy tissue from patients with juvenile dermatomyositis (JDM) in order to test the reliability of a score tool designed to quantify the severity of histological abnormalities when applied to ...

    • Validation of a smartphone-based EEG among people with epilepsy: A prospective study 

      McKenzie, Erica D.; Lim, Andrew S. P.; Leung, Edward C. W.; Cole, Andrew James; Lam, Alice; Eloyan, Ani; Nirola, Damber K.; Tshering, Lhab; Thibert, Ronald L.; Garcia, Rodrigo; Bui, Esther; Deki, Sonam; Lee, Liesly; Clark, Sarah J.; Cohen, Joseph M.; Mantia, Jo; Brizzi, Kate Teresa; Sorets, Tali R.; Wahlster, Sarah; Borzello, Mia; Stopczynski, Arkadiusz; Cash, Sydney S.; Mateen, Farrah J (Springer Nature, 2017)
      Our objective was to assess the ability of a smartphone-based electroencephalography (EEG) application, the Smartphone Brain Scanner-2 (SBS2), to detect epileptiform abnormalities compared to standard clinical EEG. The ...

    • Validation of Claims-Based Algorithms for Identification of High-Grade Cervical Dysplasia and Cervical Cancer 

      Kim, Seoyoung; Gillet, Victoria G.; Feldman, Sarah; Lii, Huichuan; Toh, Sengwee Darren; Brown, Jeffrey; Katz, Jeffrey; Solomon, Daniel; Schneeweiss, Sebastian (Wiley, 2013-11)
      Background High-grade cervical dysplasia or cervical intraepithelial neoplasia (CIN) grade 2 or worse has been widely used as a surrogate endpoint in cervical cancer screening or prevention trials. Methods To identify ...

    • Validation of Clinical Prediction Models and Study of the Role of Modern Therapies Using Real-World Data in Spine Oncology 

      Massaad, Elie (2021-06-23)
      With a rising incidence of cancer and improved life expectancy, more patients are being diagnosed and surviving longer with spinal metastases. Spinal metastases can significantly worsen patients' quality of life because ...

    • Validation of Noninvasive Measurements of Cardiac Output in Mice Using Echocardiography 

      Tournoux, François; Petersen, Bodil; Thibault, Hélène; Zou, Lin; Raher, Michael J.; Kurtz, Baptiste; Halpern, Elkan; Chaput, Miguel; Chao, Wei; Picard, Michael Howard; Scherrer-Crosbie, Marielle (Elsevier BV, 2011)
      Although multiple echocardiographic methods exist to calculate cardiac output (CO), they have not been validated in mice using a reference method. Echocardiographic and flow probe measurements of CO were obtained in mice ...

    • Validation of Oligoarrays for Quantitative Exploration of the Transcriptome 

      Nygaard, Vigdis; Holden, Marit; Trimarchi, Jeff; Ohno-Machado, Lucila; Frigessi, Arnoldo; Glad, Ingrid K; Wiel, Mark A van de; Hovig, Eivind; Lyng, Heidi; Liu, Fang; Kuo, Winston Patrick; Cepko, Connie (BioMed Central, 2008)
      Background: Oligoarrays have become an accessible technique for exploring the transcriptome, but it is presently unclear how absolute transcript data from this technique compare to the data achieved with tag-based quantitative ...

    • Validation of self-reported weights and heights in the avoiding diabetes after pregnancy trial (ADAPT) 

      Paez, Kathryn A; Griffey, Susan J; Thompson, Jennifer; Gillman, Matthew W (BioMed Central, 2014)
      Background: Randomized controlled trials that test the effectiveness of mobile health-based weight loss programs are attractive to participants, funders, and researchers because of the low implementation cost, minimal ...

    • Validation of the composite autonomic symptom scale 31 (COMPASS-31) in patients with and without small fiber polyneuropathy 

      Treister, R.; O, K.; Downs, H. M.; Oaklander, Anne Louise (Wiley-Blackwell, 2015)
      Background The recently developed composite autonomic symptom score-31 (COMPASS-31) is a questionnaire for assessing symptoms of dysautonomia. It was distilled from the well established autonomic symptom profile ...

    • Validation of the Intermountain patient perception of quality (PPQ) survey among survivors of an intensive care unit admission: a retrospective validation study 

      Brown, Samuel M; McBride, Glen; Collingridge, Dave S; Butler, Jorie M; Kuttler, Kathryn G; Hirshberg, Eliotte L; Jones, Jason P; Hopkins, Ramona O; Talmor, Daniel; Orme, James (BioMed Central, 2015)
      Background: Patients’ perceptions of the quality of their hospitalization have become important to the American healthcare system. Standard surveys of perceived quality of healthcare do not focus on the Intensive Care Unit ...

    • Validity and Cross-Cultural Adaptation of the Persian Version of the Oxford Elbow Score 

      Ebrahimzadeh, Mohammad H.; Kachooei, Amir Reza; Vahedi, Ehsan; Moradi, Ali; Mashayekhi, Zeinab; Hallaj-Moghaddam, Mohammad; Azami, Mehran; Birjandinejad, Ali (Hindawi Publishing Corporation, 2014)
      Oxford Elbow Score (OES) is a patient-reported questionnaire used to assess outcomes after elbow surgery. The aim of this study was to validate and adapt the OES into Persian language. After forward-backward translation ...

    • Validity and Reliability of a Fijian Translation and Adaptation of the Eating Disorder Examination Questionnaire 

      Becker, Anne Edith; Thomas, Jennifer Joanne; Bainivualiku, Asenaca; Richards, Lauren; Navara, Kesaia; Roberts, Andrea L; Gilman, Stephen Edward; Striegel-Moore, Ruth H (John Wiley and Sons, 2010)
      Objective: Assessment of disordered eating has uncertain validity across culturally diverse populations. This study evaluated Eating Disorder Examination Questionnaire (EDE-Q) performance in an ethnic Fijian study population. ...

    • Validity Assessment of 5 Day Repeated Forced-Swim Stress to Model Human Depression in Young-Adult C57BL/6J and BALB/cJ Mice 

      Mul, Joram D.; Zheng, Jia; Goodyear, Laurie J. (Society for Neuroscience, 2016)
      The development of animal models with construct, face, and predictive validity to accurately model human depression has been a major challenge. One proposed rodent model is the 5 d repeated forced swim stress (5d-RFSS) ...