Browsing Harvard Medical School by Title
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“You're never really off time”: Healthcare providers' interpretations of optimal timing for HPV vaccination
(Elsevier, 2016)Healthcare providers have a strong influence on human papillomavirus (HPV) vaccination decisions, yet they often fail to recommend the vaccine to the 11- and 12-year-olds who are targeted by practice guidelines. We sought ... -
Young Adult Donor Bone Marrow Infusions into Female Mice Postpone Age-Related Reproductive Failure and Improve Offspring Survival
(Impact Journals LLC, 2009)The female reproductive axis is the first major organ system of the body to fail with advancing age. In addition to a permanent cessation of fertile potential, the loss of cyclic ovarian function in humans heralds the onset ... -
Young Adult Perspectives on a Successful Transition from Pediatric to Adult Care in Sickle Cell Disease
(2016)Objective: This qualitative study sought to learn from young adults with sickle cell disease (SCD) about their experience leaving pediatric care and perspective on what makes a successful transition. Methods: Fifteen young ... -
Young Adults, Social Networks, and Addiction Recovery: Post Treatment Changes in Social Ties and Their Role as a Mediator of 12-Step Participation
(Public Library of Science, 2014)Background: Social factors play a key role in addiction recovery. Research with adults indicates individuals with substance use disorder (SUD) benefit from mutual-help organizations (MHOs), such as Alcoholics Anonymous, ... -
Young Hispanic Women Experience Higher In-Hospital Mortality Following an Acute Myocardial Infarction
(John Wiley & Sons, Ltd, 2015)Background: Although mortality rates for acute myocardial infarction (AMI) have declined for men and women, prior studies have reported a sex gap in mortality such that younger women were most likely to die after an AMI. ... -
Young Hispanics at risk of type 2 diabetes display endothelial activation, subclinical inflammation and alterations of coagulation and fibrinolysis
(BioMed Central, 2013)Background: Hispanics have a high rate of diabetes that exposes them to an increased risk of cardiovascular disease. We hypothesized that many of the pathophysiological mechanisms that cause atherosclerotic disease may be ... -
Young professionals for health development: the Kenyan experience in combating non-communicable diseases
(Co-Action Publishing, 2013)Young individuals (below 35 years) comprise an estimated 60% of the global population. Not only are these individuals currently experiencing chronic, non-communicable diseases (NCDs), either living with or at risk for these ... -
Young systemic factors as a medicine for age-related neurodegenerative diseases
(Taylor & Francis, 2015)It is widely known that neurogenesis, brain function and cognition decline with aging. Increasing evidence suggests that cerebrovascular dysfunction is a major cause of cognitive impairment in the elderly but is also ... -
Your Father and Grandfather's Atrial Fibrillation: A Review of the Genetics of the Most Common Pathologic Cardiac Dysrhythmia
(Bentham Science Publishers, 2015)Atrial fibrillation (AF) remains the most common pathologic dysrhythmia in humans with a prevalence of 1-2% of the total population and as high as 10% of the elderly. AF is an independent risk marker for cardiovascular ... -
Yttrium-90 Radioembolization of Hepatic Metastases from Colorectal Cancer
(Frontiers Media S.A., 2014)Liver metastases from colorectal cancer (CRC) result in substantial morbidity and mortality. The primary treatment is systemic chemotherapy, and in selected patients, surgical resection; however, for patients who are not ... -
YY1 Regulates Melanocyte Development and Function by Cooperating with MITF
(Public Library of Science, 2012)Studies of coat color mutants have greatly contributed to the discovery of genes that regulate melanocyte development and function. Here, we generated Yy1 conditional knockout mice in the melanocyte-lineage and observed ... -
Zcchc11 Uridylates Mature miRNAs to Enhance Neonatal IGF-1 Expression, Growth, and Survival
(Public Library of Science, 2012)The Zcchc11 enzyme is implicated in microRNA (miRNA) regulation. It can uridylate let-7 precursors to decrease quantities of the mature miRNA in embryonic stem cell lines, suggested to mediate stem cell maintenance. It can ... -
ZDHHC7-Mediated S-Palmitoylation of Scribble Regulates Cell Polarity
(2016)Scribble (SCRIB) is a tumor suppressor protein, playing critical roles in establishing and maintaining epithelial cell polarity. Paradoxically, SCRIB is frequently amplified in human cancers, however, fails to localize ... -
Zebrafish behavioral profiling identifies multi-target antipsychotic-like compounds
(2016)Many psychiatric drugs act on multiple targets and therefore require screening assays that encompass a wide target space. With sufficiently rich phenotyping, and a large sampling of compounds, it should be possible to ... -
A zebrafish model of conditional targeted podocyte ablation and regeneration
(2013)Podocytes are specialized cells that contribute critically to the normal structure and function of the glomerular filtration barrier. Their depletion plays an important role in the pathogenesis of glomerulosclerosis. Here, ... -
Zebrafish models of cerebrovascular disease
(Nature Publishing Group, 2014)Perturbations in cerebral blood flow and abnormalities in blood vessel structure are the hallmarks of cerebrovascular disease. While there are many genetic and environmental factors that affect these entities through a ... -
Zebrafish orthologs of human muscular dystrophy genes
(BioMed Central, 2007)Background: Human muscular dystrophies are a heterogeneous group of genetic disorders which cause decreased muscle strength and often result in premature death. There is no known cure for muscular dystrophy, nor have all ... -
Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis
(Company of Biologists, 2013)Rhabdomyosarcoma is a pediatric malignancy thought to arise from the uncontrolled proliferation of myogenic cells. Here, we have generated models of rhabdomyosarcoma in the zebrafish by inducing oncogenic KRAS(G12D) ... -
Zebrafish VEGF Receptors: A Guideline to Nomenclature
(Public Library of Science, 2008) -
zebraflash transgenic lines for in vivo bioluminescence imaging of stem cells and regeneration in adult zebrafish
(Company of Biologists, 2013)The zebrafish has become a standard model system for stem cell and tissue regeneration research, based on powerful genetics, high tissue regenerative capacity and low maintenance costs. Yet, these studies can be challenged ...