Browsing Harvard Medical School by Title
Now showing items 4260-4279 of 18428
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Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment
(National Academy of Sciences, 2010)Most genetically engineered mouse (GEM) models for colon cancer are based on tissuewide or germline gene modification, resulting in tumors predominantly of the small intestine. Several of these models involve modification ... -
Development of a new pre-vascularized tissue-engineered construct using pre-differentiated rADSCs, arteriovenous vascular bundle and porous nano-hydroxyapatide-polyamide 66 scaffold
(BioMed Central, 2013)Background: Development of a pre-vascularized tissue-engineered construct with intrinsic vascular system for cell growth and tissue formation still faces many difficulties due to the complexity of the vascular network of ... -
Development of a New Risk Score for Incident Type 2 Diabetes Using Updated Diagnostic Criteria in Middle-Aged and Older Chinese
(Public Library of Science, 2014)Type 2 diabetes mellitus (T2DM) reaches an epidemic proportion among adults in China. However, no simple score has been created for the prediction of T2DM incidence diagnosed by updated criteria with hemoglobin A1c (HbA1c) ... -
Development of a Novel Risk Prediction Model for Cisplatin Nephrotoxicity
(2016-05-18)Cisplatin is a chemotherapy drug that will be used to treat approximately 850,000 new cancer patients in 2015. Despite decades of its use, toxicity to the kidney remains a problem in 25-30% of the patients. Given the high ... -
Development of a positive psychology intervention for patients with acute cardiovascular disease
(PAGEPress Publications, 2011)The management of depression and other negative psychological states in cardiac patients has been a focus of multiple treatment trials, though such trials have not led to substantial improvements in cardiac outcomes. In ... -
Development of a process to disclose amyloid imaging results to cognitively normal older adult research participants
(BioMed Central, 2015)Introduction: The objective of this study was to develop a process to maximize the safety and effectiveness of disclosing Positron Emission Tomography (PET) amyloid imaging results to cognitively normal older adults ... -
Development of a Reactive Stroma Associated with Prostatic Intraepithelial Neoplasia in EAF2 Deficient Mice
(Public Library of Science, 2013)ELL-associated factor 2 (EAF2) is an androgen-responsive tumor suppressor frequently deleted in advanced prostate cancer that functions as a transcription elongation factor of RNA Pol II through interaction with the ELL ... -
Development of a Scalable Pharmacogenomic Clinical Decision Support Service
(American Medical Informatics Association, 2013)Advances in sequencing technology are making genomic data more accessible within the healthcare environment. Published pharmacogenetic guidelines attempt to provide a clinical context for specific genomic variants; however, ... -
Development of a scale to measure individuals’ ratings of peace
(BioMed Central, 2014)Background: The evolving concept of peace-building and the interplay between peace and health is examined in many venues, including at the World Health Assembly. However, without a metric to determine effectiveness of ... -
Development of a unidimensional composite measure of neuropsychological functioning in older cardiac surgery patients with good measurement precision
(Informa UK Limited, 2010)The objective of this analysis was to develop a measure of neuropsychological performance for cardiac surgery and to assess its psychometric properties. Older patients (n = 210) underwent a neuropsychological battery using ... -
Development of a Vietnamese Language Outbreak Mapping and Surveillance System
(University of Illinois at Chicago Library, 2013)Objective: To present the development of a surveillance system utilizing online Vietnamese language media sources to detect disease events in Vietnam and the South East Asian Region. Introduction: In the South East Asia ... -
Development of an Algorithm for Surveillance of Ventilator-Associated Pneumonia with Electronic Data and Comparison of Algorithm Results with Clinician Diagnoses
(Cambridge University Press, 2008)objective. Surveillance for ventilator-associated pneumonia (VAP) using standard Centers for Disease Control and Prevention (CDC) criteria is labor intensive and involves many subjective assessments. We sought to improve ... -
Development of an IgG4-RD Responder Index
(Hindawi Publishing Corporation, 2012)IgG4-related disease (IgG4-RD) is a multiorgan inflammatory disease in which diverse organ manifestations are linked by common histopathological and immunohistochemical features. Prospective studies of IgG4-RD patients are ... -
Development of an open-source, flexible framework for complex inter-institutional disparate data sharing and collaboration
(American Medical Informatics Association, 2013)Clinical information, “-omic” datasets, and tissue samples are difficult to harmonize and manage for data mining. We have developed a platform for storing clinical research data while providing access to associated data ... -
Development of an Optimized Synthetic Notch Receptor as an in Vivo Cell–Cell Contact Sensor
(National Academy of Sciences, 2017-05-23)Detection and manipulation of direct cell–cell contact in complex tissues is a fundamental and challenging problem in many biological studies. Here, we report an optimized Notch-based synthetic receptor (synNQ) useful to ... -
Development of an Ultrasound Training Curriculum in a Limited Resource International Setting: Successes and Challenges of Ultrasound Training in Rural Rwanda
(Springer-Verlag, 2008)Background: Over the last decade, the diffusion of ultrasound technology to nontraditional users has been rapid and far-reaching. Much research and effort has been focused on developing an ultrasound curriculum and training ... -
Development of Antipsychotic Medications with Novel Mechanisms of Action Based on Computational Modeling of Hippocampal Neuropathology
(Public Library of Science, 2013)A large number of cellular level abnormalities have been identified in the hippocampus of schizophrenic subjects. Nonetheless, it remains uncertain how these pathologies interact at a system level to create clinical symptoms, ... -
Development of Fatal Intestinal Inflammation in MyD88 Deficient Mice Co-infected with Helminth and Bacterial Enteropathogens
(Public Library of Science, 2014)Infections with intestinal helminth and bacterial pathogens, such as enteropathogenic Escherichia coli, continue to be a major global health threat for children. To determine whether and how an intestinal helminth parasite, ... -
Development of heart valves requires Gata4 expression in endothelial-derived cells
(Company of Biologists, 2006)Cardiac malformations due to aberrant development of the atrioventricular (AV) valves are among the most common forms of congenital heart disease. At localized swellings of extracellular matrix known as the endocardial ... -
Development of Immunoglobulin M Memory to Both a T-Cell-Independent and a T-Cell-Dependent Antigen following Infection with Vibrio cholerae O1 in Bangladesh
(American Society for Microbiology, 2010)Vibrio cholerae O1 can cause severe watery diarrhea that can be life-threatening without treatment. Infection results in long-lasting protection against subsequent disease. Development of memory B cells of the immunoglobulin ...