Browsing Harvard Medical School by Title
Now showing items 511-530 of 18428
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Age- and Pregnancy-Associated DNA Methylation Changes in Mammary Epithelial Cells
(Elsevier, 2015)Summary Postnatal mammary gland development and differentiation occur during puberty and pregnancy. To explore the role of DNA methylation in these processes, we determined the genome-wide DNA methylation and gene expression ... -
Age-adjusted nonparametric detection of differential DNA methylation with case–control designs
(BioMed Central, 2013)Background: DNA methylation profiles differ among disease types and, therefore, can be used in disease diagnosis. In addition, large-scale whole genome DNA methylation data offer tremendous potential in understanding the ... -
Age-associated NF-κB signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function
(Impact Journals LLC, 2016)Skeletal muscle is a highly regenerative tissue, but muscle repair potential is increasingly compromised with advancing age. In this study, we demonstrate that increased NF-κB activity in aged muscle fibers contributes to ... -
AGE-BSA decreases ABCG1 expression and reduces macrophage cholesterol efflux to HDL
(Elsevier BV, 2007)Background Previous reports have suggested that advanced glycation end products (AGE) participate in the pathogenesis of diabetic macroangiopathy. However, current understanding of the mechanisms by which AGE may accelerate ... -
Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants
(eLife Sciences Organisation, Ltd., 2015)Electroencephalogram (EEG) approaches may provide important information about developmental changes in brain-state dynamics during general anesthesia. We used multi-electrode EEG, analyzed with multitaper spectral methods ... -
Age-Dependent Iris Abnormalities in Collagen XVIII/Endostatin Deficient Mice with Similarities to Human Pigment Dispersion Syndrome
(Association for Research in Vision and Ophthalmology (ARVO), 2003-06-01)Purpose: Collagen XVIII is expressed in ocular basement membranes (BMs) and inactivating mutations cause Knobloch syndrome, with several ocular abnormalities. In this study we investigated ocular structures in collagen ... -
Age-Dependent Maturation of Toll-Like Receptor-Mediated Cytokine Responses in Gambian Infants
(Public Library of Science, 2011)The global burden of neonatal and infant mortality due to infection is staggering, particularly in resource-poor settings. Early childhood vaccination is one of the major interventions that can reduce this burden, but there ... -
Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice
(Nature Publishing Group, 2014)Post-operative cognitive dysfunction (POCD) is associated with increased cost of care, morbidity, and mortality. However, its pathogenesis remains largely to be determined. Specifically, it is unknown why elderly patients ... -
Age-Related Associations of Hypertension and Diabetes Mellitus with Chronic Kidney Disease
(BioMed Central, 2009)Background: Studies suggest end-stage renal disease incidence and all-cause mortality rates among patients with chronic kidney disease (CKD) differ by age. The association of diabetes mellitus and hypertension with CKD ... -
Age-related changes in early novelty processing as measured by ERPs
(Elsevier BV, 2009)This study investigated age-related changes in the early processing of novel visual stimuli using ERPs. Well-matched old (n=30), middle-aged (n=30), and young (n=32) subjects were presented standard, target/rare, and ... -
Age-related changes in the electrophysiological response to visual stimulus novelty: A topographical approach
(Elsevier BV, 1996)The relationship of task relevance and stimulus probability to P300 morphology, latency and distribution was assessed. Eight year olds and adults completed visual oddball tasks of recognition memory with frequent non-target ... -
Age-Related Decline in Cardiorespiratory Fitness among Career Firefighters: Modification by Physical Activity and Adiposity
(Hindawi Publishing Corporation, 2012)Firefighting is a very hazardous occupation, and strenuous fire duties require high levels of physical fitness. In the general adult population, cardiorespiratory fitness (CRF) declines with aging. We sought to investigate ... -
Age-related decline in white matter tract integrity and cognitive performance: A DTI tractography and structural equation modeling study
(Elsevier BV, 2012)Age-related decline in microstructural integrity of certain white matter tracts may explain cognitive decline associated with normal aging. Whole brain tractography and a clustering segmentation in 48 healthy individuals ... -
Age-related deficits in fronto-temporal connections in schizophrenia: A diffusion tensor imaging study
(Elsevier BV, 2008-07)Objective: Impairment of white matter connecting frontal and temporal cortices has been reported in schizophrenia. Yet, not much is known about the effects of age on fibers connecting these brain regions. Using diffusion ... -
Age-Related Differences in Attention to Novelty Among Cognitively High Performing Adults
(Elsevier BV, 2006)Age-related differences in attention to novel events were studied in well-matched, cognitively high performing old, middle-aged and young subjects. Event-related potentials were recorded during a visual novelty oddball ... -
Age-related differences in enhancement and suppression of neural activity underlying selective attention in matched young and old adults
(Elsevier BV, 2013)Selective attention reflects the top-down control of sensory processing that is mediated by enhancement or inhibition of neural activity. ERPs were used to investigate age-related differences in neural activity in an ... -
Age-related differences in the automatic processing of single letters
(Ovid Technologies (Wolters Kluwer Health), 2014)Older adults exhibit diminished ability to inhibit the processing of visual stimuli that are supposed to be ignored. The extent to which age-related changes in early visual processing contribute to impairments in selective ... -
Age-Related Macular Degeneration and the Incidence of Cardiovascular Disease: A Systematic Review and Meta-Analysis
(Public Library of Science, 2014)Importance Research has indicated some shared pathogenic mechanisms between age-related macular degeneration (AMD) and cardiovascular disease (CVD). However, results from prior epidemiologic studies have been inconsistent ... -
Age-Related Patterns in Clinical Presentations and Gluten-Related Issues Among Children and Adolescents With Celiac Disease
(Nature Publishing Group, 2012)OBJECTIVES: Celiac disease (CD) is common and often cited as an “iceberg” phenomenon (i.e., an assumed large number of undiagnosed cases). Recently, atypical or asymptomatic manifestations are becoming more commonly described ... -
Age-related striatal BOLD changes without changes in behavioral loss aversion
(Frontiers Media S.A., 2015)Loss aversion (LA), the idea that negative valuations have a higher psychological impact than positive ones, is considered an important variable in consumer research. The literature on aging and behavior suggests older ...