Browsing Harvard Medical School by Title
Now showing items 737-756 of 18423
-
Amygdala and Fusiform Gyrus Temporal Dynamics: Responses to Negative Facial Expressions
(BioMed Central, 2008)Background: The amygdala habituates in response to repeated human facial expressions; however, it is unclear whether this brain region habituates to schematic faces (i.e., simple line drawings or caricatures of faces). ... -
Amygdala Perfusion Is Predicted by Its Functional Connectivity with the Ventromedial Prefrontal Cortex and Negative Affect
(Public Library of Science, 2014)Background: Previous studies have shown that the activity of the amygdala is elevated in people experiencing clinical and subclinical levels of anxiety and depression (negative affect). It has been proposed that a reduction ... -
Amygdala-enriched genes identified by microarray technology are restricted to specific amygdaloid subnuclei
(Proceedings of the National Academy of Sciences, 2001)Microarray technology represents a potentially powerful method for identifying cell type- and regionally restricted genes expressed in the brain. Here we have combined a microarray analysis of differential gene expression ... -
Amygdalar Activity Measured Using FDG-PET/CT at Head and Neck Cancer Staging Independently Predicts Survival and Cardiovascular Outcomes: A Retrospective Cohort Study
(2019-06-03)Background Chronic stress associates with higher mortality among individuals with cancer; however, the mechanisms underlying this association remain incompletely understood. Quantification of amygdalar metabolic activity ... -
Amygdala–hippocampal shape differences in schizophrenia: the application of 3D shape models to volumetric MR data
(Elsevier BV, 2002)Evidence suggests that some structural brain abnormalities in schizophrenia are neurodevelopmental in origin. There is also growing evidence to suggest that shape deformations in brain structure may reflect abnormalities ... -
Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease
(BioMed Central, 2015)Introduction: In early stages of Alzheimer’s disease (AD), neurofibrillary tangles (NFT) are largely restricted to the entorhinal cortex and medial temporal lobe. At later stages, when clinical symptoms generally occur, ... -
The amyloid hypothesis of Alzheimer's disease at 25 years
(John Wiley and Sons Inc., 2016)Abstract Despite continuing debate about the amyloid β‐protein (or Aβ hypothesis, new lines of evidence from laboratories and clinics worldwide support the concept that an imbalance between production and clearance of Aβ42 ... -
The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase
(eLife Sciences Publications, Ltd, 2016)γ-secretase is responsible for the proteolysis of amyloid precursor protein (APP) into short, aggregation-prone amyloid-beta (Aβ) peptides, which are centrally implicated in the pathogenesis of Alzheimer’s disease (AD). ... -
Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity
(Nature Pub. Group, 2013)Growing evidence suggests water-soluble, non-fibrillar forms of amyloid-β protein (Aβ) have important roles in Alzheimer’s disease with toxicities mimicked by synthetic Aβ1–42. However, no defined toxic structures acting ... -
Amyloid-β Protein Protects Against Microbial Infection In Transgenic C. elegans and 5XFAD Mice
(American Association for the Advancement of Science (AAAS), 2016)The amyloid-β peptide (Aβ) is a key protein in Alzheimer's disease (AD) pathology. We previously reported in vitro evidence suggesting Aβ is an antimicrobial peptide. Here we provide the first in vivo evidence showing high ... -
An antiviral role for the RNA interference machinery in Caenorhabditis elegans
(National Academy of Sciences, 2005)RNA interference (RNAi) is a sequence-specific gene-silencing mechanism triggered by exogenous dsRNA. In plants an RNAi-like mechanism defends against viruses, but the hypothesis that animals possess a similar natural ... -
An Apgar Score for Surgery
(2007)BACKGROUND: Surgical teams have not had a routine, reliable measure of patient condition at the end of an operation. We aimed to develop an Apgar score for the field of surgery, an outcomes score that teams could calculate ... -
An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle
(National Academy of Sciences, 2003) -
An Escherichia coli O157-Specific Engineered Pyocin Prevents and Ameliorates Infection by E. coli O157:H7 in an Animal Model of Diarrheal Disease
(American Society for Microbiology, 2011)AvR2-V10.3 is an engineered R-type pyocin that specifically kills Escherichia coli O157, an enteric pathogen that is a major cause of food-borne diarrheal disease. New therapeutics to counteract E. coli O157 are needed, ... -
An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris
(National Academy of Sciences, 2009)Clinical and experimental observations indicate a role for VEGF secreted by the retinal pigment epithelium (RPE) in the maintenance of the choriocapillaris (CC). VEGF in mice is produced as three isoforms, VEGF120, VEGF164, ... -
An Externalized Polypeptide Partitions between Two Distinct Sites on Genome-Released Poliovirus Particles
(American Society for Microbiology, 2011)During cell entry, native poliovirus (160S) converts to a cell-entry intermediate (135S) particle, resulting in the externalization of capsid proteins VP4 and the amino terminus of VP1 (residues 1 to 53). Externalization ... -
An in Trans Interaction at the Interface of the Helicase and Primase Domains of the Hexameric Gene 4 Protein of Bacteriophage T7 Modulates Their Activities
(American Society for Biochemistry and Molecular Biology, 2009)DNA helicase and primase are essential for DNA replication. The helicase unwinds the DNA to provide single-stranded templates for DNA polymerase. The primase catalyzes the synthesis of oligoribonucleotides for the initiation ... -
An in Vitro RNA Synthesis Assay for Rabies Virus Defines Ribonucleoprotein Interactions Critical for Polymerase Activity
(American Society for Microbiology, 2017)We report an in vitro RNA synthesis assay for the RNA-dependent RNA polymerase (RdRP) of rabies virus (RABV). We expressed RABV large polymerase protein (L) in insect cells from a recombinant baculovirus vector and the ... -
An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma
(National Academy of Sciences, 2015)High-grade serous ovarian carcinoma (HGSOC) is the most common and aggressive form of epithelial ovarian cancer, for which few targeted therapies exist. To search for new therapeutic target proteins, we performed an in ...