Browsing Harvard Medical School by Title

Now showing items 790-809 of 18428

    • Analysis of Monocusp Valve Design for Reconstruction of Right Ventricular Outflow Tract in Tetralogy of Fallot: An In Vitro Study 

      Zhang, Xiaoya (2022-05-10)
      Tetralogy of Fallot (TOF) is one of the most common cyanotic congenital heart diseases (CHD), which accounts for approximately 10 percent of all CHD1, requiring intervention in the first year of life. Cardiac surgeons ...

    • Analysis of Morphological Parameters to Differentiate Rupture Status in Anterior Communicating Artery Aneurysms 

      Lin, Ning; Ho, Allen; Charoenvimolphan, Nareerat; Frerichs, Kai U.; Day, Arthur L.; Du, Rose (Public Library of Science, 2013)
      In contrast to size, the association of morphological characteristics of intracranial aneurysms with rupture has not been established in a systematic manner. We present an analysis of the morphological variables that are ...

    • Analysis of Multiple Sarcoma Expression Datasets: Implications for Classification, Oncogenic Pathway Activation and Chemotherapy Resistance 

      Konstantinopoulos, Panagiotis; Fountzilas, Elena; Goldsmith, Jeffrey David; Bhasin, Manoj; Pillay, Kamana; Francoeur, Nancy; Libermann, Towia Aron; Gebhardt, Mark Clyde; Spentzos, Dimitrios (Public Library of Science, 2010)
      Background: Diagnosis of soft tissue sarcomas (STS) is challenging. Many remain unclassified (not-otherwise-specified, NOS) or grouped in controversial categories such as malignant fibrous histiocytoma (MFH), with unclear ...

    • Analysis of Multiple-cycle Data From Couples Undergoing In Vitro Fertilization 

      Missmer, Stacey Ann; Pearson, Kimberly Hope; Ryan, Louise Marie; Meeker, John D.; Cramer, Daniel William; Hauser, Russ B. (Ovid Technologies (Wolters Kluwer Health), 2011)
      The number of in vitro fertilization (IVF) cycles in the U.S. increased from fewer than 46,000 in 1995 to more than 120,000 in 2005. IVF and other assisted reproductive technology (ART) data are routinely collected and ...

    • Analysis of Myeloid Derived Suppressor Cells and the Role of Inducible Nitric Oxide Synthase in Renal Transplantation Across MHC Mismatched Mice 

      Aljabban, Imad (2016-05-24)
      Despite recent advances in immunology and post-operative care, transplant recipients continue to face major complications. This is due to immune-mediated destruction of graft tissue and drug toxicity caused by chronic ...

    • Analysis of optimality in natural and perturbed metabolic networks 

      Segre, Daniel; Vitkup, Dennis; Church, George (Proceedings of the National Academy of Sciences, 2002-11)
      An important goal of whole-cell computational modeling is to integrate detailed biochemical information with biological intuition to produce testable predictions. Based on the premise that prokaryotes such as Escherichia ...

    • Analysis of optimized DNase-seq reveals intrinsic bias in transcription factor footprint identification 

      He, Housheng Hansen; Meyer, Clifford A.; Hu, Sheng'en Shawn; Chen, Mei-Wei; Zang, Chongzhi; Liu, Yin; Rao, Prakash K.; Fei, Teng; Xu, Han; Long, Henry; Liu, X. Shirley; Brown, Myles (2014)
      DNase-seq is a powerful technique for identifying cis-regulatory elements across the genome. We studied the key experimental parameters to optimize the performance of DNase-seq. We found that sequencing short 50-100bp ...

    • Analysis of Over 10,000 Cases Finds No Association between Previously Reported Candidate Polymorphisms and Ovarian Cancer Outcome 

      White, K. L.; Vierkant, R. A.; Fogarty, Z. C.; Charbonneau, B.; Block, M. S.; Pharoah, P. D. P.; Chenevix-Trench, G.; Rossing, M. A.; Cramer, Daniel William; Pearce, C. L.; Schildkraut, J. M.; Menon, U.; Kjaer, S. K.; Levine, D. A.; Gronwald, J.; Culver, H. A.; Whittemore, A. S.; Karlan, B. Y.; Lambrechts, D.; Wentzensen, N.; Kupryjanczyk, J.; Chang-Claude, J.; Bandera, E. V.; Hogdall, E.; Heitz, F.; Kaye, S. B.; Fasching, P. A.; Campbell, I.; Goodman, M. T.; Pejovic, T.; Bean, Y.; Lurie, G.; Eccles, D.; Hein, A.; Beckmann, M. W.; Ekici, A. B.; Paul, J.; Brown, R.; Flanagan, J. M.; Harter, P.; du Bois, A.; Schwaab, I.; Hogdall, C. K.; Lundvall, L.; Olson, S. H.; Orlow, I.; Paddock, L. E.; Rudolph, A.; Eilber, U.; Dansonka-Mieszkowska, A.; Rzepecka, I. K.; Ziolkowska-Seta, I.; Brinton, L.; Yang, H.; Garcia-Closas, M.; Despierre, E.; Lambrechts, S.; Vergote, I.; Walsh, C.; Lester, J.; Sieh, W.; McGuire, V.; Rothstein, J. H.; Ziogas, A.; Lubinski, J.; Cybulski, C.; Menkiszak, J.; Jensen, A.; Gayther, S. A.; Ramus, S. J.; Gentry-Maharaj, A.; Berchuck, A.; Wu, A. H.; Pike, M. C.; Van DenBerg, D.; Terry, Kathryn Lynne; Vitonis, A. F.; Doherty, J. A.; Johnatty, S. E.; deFazio, A.; Song, H.; Tyrer, J.; Sellers, T. A.; Phelan, C. M.; Kalli, K. R.; Cunningham, J. M.; Fridley, B. L.; Goode, E. L. (American Association for Cancer Research (AACR), 2013)
      Background Ovarian cancer is a leading cause of cancer-related death among women. In an effort to understand contributors to disease outcome, we evaluated single-nucleotide polymorphisms (SNPs) previously associated ...

    • Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3′-5′)-cyclic-GMP in virulence 

      Kulesekara, Hemantha; Lee, Vincent; Brencic, Anja; Liberati, Nicole; Urbach, Jonathan; Miyata, Sachiko; Lee, Daniel; Neely, Alice; Hyodo, Mamoru; Hayakawa, Yoshihiro; Ausubel, Frederick; Lory, Stephen (National Academy of Sciences, 2006)
      The opportunistic pathogen Pseudomonas aeruginosa is responsible for systemic infections in immunocompromised individuals and chronic respiratory disease in patients with cystic fibrosis. Cyclic nucleotides are known to ...

    • Analysis of rapidly synthesized guest-filled porous complexes with synchrotron radiation: practical guidelines for the crystalline sponge method 

      Ramadhar, Timothy R.; Zheng, Shao-Liang; Chen, Yu-Sheng; Clardy, Jon (International Union of Crystallography, 2015)
      A detailed set of synthetic and crystallographic guidelines for the crystalline sponge method based upon the analysis of expediently synthesized crystal sponges using third-generation synchrotron radiation are reported. ...

    • Analysis of Rare, Exonic Variation amongst Subjects with Autism Spectrum Disorders and Population Controls 

      Liu, Li; Sabo, Aniko; Neale, Benjamin Michael; Nagaswamy, Uma; Stevens, Christine; Lim, Elaine; Bodea, Corneliu A.; Muzny, Donna; Reid, Jeffrey G.; Banks, Eric; Coon, Hillary; DePristo, Mark; Dinh, Huyen; Fennel, Tim; Flannick, Jason A.; Gabriel, Stacey; Garimella, Kiran; Gross, Shannon; Hawes, Alicia; Lewis, Lora; Makarov, Vladimir; Maguire, Jared; Newsham, Irene; Poplin, Ryan; Ripke, Stephan; Shakir, Khalid; Samocha, Kaitlin Elisabeth; Wu, Yuanqing; Boerwinkle, Eric; Buxbaum, Joseph D.; Cook, Edwin H., Jr.; Devlin, Bernie; Schellenberg, Gerard D.; Sutcliffe, James S.; Daly, Mark Joseph; Gibbs, Richard A.; Roeder, Kathryn (Public Library of Science, 2013)
      We report on results from whole-exome sequencing (WES) of 1,039 subjects diagnosed with autism spectrum disorders (ASD) and 870 controls selected from the NIMH repository to be of similar ancestry to cases. The WES data ...

    • Analysis of Regional Mechanics in Canine Lung Injury Using Forced Oscillations and 3D Image Registration 

      Kaczka, David; Cao, Kunlin; Christensen, Gary E.; Bates, Jason H. T.; Simon, Brett A (Springer US, 2011)
      Acute lung injury is characterized by heterogeneity of regional mechanical properties, which is thought to be correlated with disease severity. The feasibility of using respiratory input impedance (\(Z_{rs}\)) and computed ...

    • Analysis of Report Addenda as a Novel Approach to Characterization and Quantification of Errors in Diagnostic Radiology 

      Brigham, Leeann (2015-06-08)
      Diagnostic errors are common in radiology and can have a significant negative impact on patient care. Identifying the types of errors that occur can improve our understanding of the root causes and suggest pathways for ...

    • Analysis of Salmonella enterica Serotype Paratyphi A Gene Expression in the Blood of Bacteremic Patients in Bangladesh 

      Sheikh, Alaullah; Bhuiyan, Md. Saruar; Khanam, Farhana; Bukka, Archana; Kalsy, Anuj; Porwollik, Steffen; Cravioto, Alejandro; Logvinenko, Tanya; McClelland, Michael; Graham, James E.; Qadri, Firdausi; Charles, Richelle Candice; Rollins, Sean McKenzie; Harris, Jason B.; Brooks, W. Abdullah; Larocque, Regina Celes; Hohmann, Elizabeth Louise; Calderwood, Stephen Beaven; Ryan, Edward Thomas (Public Library of Science, 2010)
      Background: Salmonella enterica serotype Paratyphi A is a human-restricted cause of paratyphoid fever, accounting for up to a fifth of all cases of enteric fever in Asia. Methodology/Principal Findings: In this work, we ...

    • Analysis of schizophrenia-related genes and electrophysiological measures reveals ZNF804A association with amplitude of P300b elicited by novel sounds 

      del Re, E C; Bergen, S E; Mesholam-Gately, R I; Niznikiewicz, M A; Goldstein, J M; Woo, T U; Shenton, Martha E.; Seidman, L J; McCarley, R W; Petryshen, T L (Nature Publishing Group, 2014)
      Several genes have recently been identified as risk factors for schizophrenia (SZ) by genome-wide association studies (GWAS), including ZNF804A which is thought to function in transcriptional regulation. However, the ...

    • Analysis of Sequence Conservation at Nucleotide Resolution 

      Asthana, Saurabh; Roytberg, Mikhail; Stamatoyannopoulos, John; Sunyaev, Shamil R. (Public Library of Science, 2007)
      One of the major goals of comparative genomics is to understand the evolutionary history of each nucleotide in the human genome sequence, and the degree to which it is under selective pressure. Ascertainment of selective ...

    • The analysis of social network data: an exciting frontier for statisticians 

      O'Malley, James James (Blackwell Publishing Ltd, 2013)
      The catalyst for this paper is the recent interest in the relationship between social networks and an individual's health, which has arisen following a series of papers by Nicholas Christakis and James Fowler on person- ...

    • Analysis of Somatic Microsatellite Indels Identifies Driver Events in Human Tumors 

      Maruvka, Yosef; Mouw, Kent; Karlic, Rosa; Parasuraman, Prasanna; Kamburov, Atanas; Polak, Paz; Haradhvala, Nicholas; Hess, Julian; Rheinbay, Esther; Brody, Yehuda; Koren, Amnon; Braunstein, Lior; D'Andrea, Alan; Lawrence, Michael; Bass, Adam; Bernards, Andre; Michor, Franziska; Getz, Gad (Springer Science and Business Media LLC, 2017-09-11)
      Microsatellites (MSs) are tracts of variable-length repeats of short DNA motifs that exhibit high rates of mutation in the form of insertions or deletions (indels) of the repeated motif. Despite their prevalence, the ...

    • Analysis of somatic retrotransposition in human cancers 

      Lee, Eunjung; Iskow, Rebecca; Yang, Lixing; Gokcumen, Omer; Haseley, Psalm; Luquette, Lovelace J.; Lohr, Jens Guenter; Harris, Christopher C; Ding, Li; Wilson, Richard K.; Wheeler, David A.; Gibbs, Richard A; Kucherlapati, Raju; Lee, Charles; Kharchenko, Peter Vasili; Park, Peter J. (BioMed Central, 2012)

    • Analysis of Surgical Errors in Closed Malpractice Claims at 4 Liability Insurers 

      Rogers, Selwyn O.; Gawande, Atul; Kwaan, Mary; Puopolo, Ann Louise; Yoon, Catherine; Brennan, Troyen A.; Studdert, David M. (2006)