Browsing Harvard Medical School by Title

Now showing items 8083-8102 of 18428

    • Human Immunodeficiency Virus Type 1 Specific Cytotoxic T Lymphocyte Responses in Chinese Infected with HIV-1 B'/C Recombinant (CRF07_BC) 

      Chen, Jianping; Hong, Kunxue; Jia, Mingming; Liu, Hongwei; Zhang, Yuanzhi; Zhang, Xiaoqing; Zhao, Hongjing; Peng, Hong; Ma, Pengfei; Xing, Hui; Ruan, Yuhua; Shao, Yiming; Liu, Sha; Altfeld, Marcus; Walker, Bruce David; Williams, Katie L.; Yu, Xu G. (BioMed Central, 2007)
      Background: The characterization of HIV-1-specific T cell responses in people infected with locally circulating HIV-1 strain will facilitate the development of HIV-1 vaccine. Sixty intravenous drug users infected with HIV-1 ...

    • Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability 

      Silva, M. Catarina; Cheng, Chialin; Mair, Waltraud; Almeida, Sandra; Fong, Helen; Biswas, M. Helal U.; Zhang, Zhijun; Huang, Yadong; Temple, Sally; Coppola, Giovanni; Geschwind, Daniel H.; Karydas, Anna; Miller, Bruce L.; Kosik, Kenneth S.; Gao, Fen-Biao; Steen, Judith A.; Haggarty, Stephen J. (Elsevier, 2016)
      Summary Frontotemporal dementia (FTD) and other tauopathies characterized by focal brain neurodegeneration and pathological accumulation of proteins are commonly associated with tau mutations. However, the mechanism of ...

    • Human Kidney Disease-causing INF2 Mutations Perturb Rho/Dia Signaling in the Glomerulus 

      Sun, Hua; Al-Romaih, Khaldoun I.; MacRae, Calum A.; Pollak, Martin R. (Elsevier, 2014)
      Mutations in Inverted Formin 2 (INF2), a diaphanous formin family protein that regulates actin cytoskeleton dynamics, cause focal segmental glomerulosclerosis (FSGS) and Charcot–Marie–Tooth Disease (CMT) in humans. In ...

    • Human Leg Model Predicts Ankle Muscle-Tendon Morphology, State, Roles and Energetics in Walking 

      Krishnaswamy, Pavitra; Brown, Emery Neal; Herr, Hugh M. (Public Library of Science, 2011)
      A common feature in biological neuromuscular systems is the redundancy in joint actuation. Understanding how these redundancies are resolved in typical joint movements has been a long-standing problem in biomechanics, ...

    • Human Leukocyte Antigen Typing Using a Knowledge Base Coupled with a High-Throughput Oligonucleotide Probe Array Analysis 

      Zhang, Guang Lan; Keskin, Derin B.; Lin, Hsin-Nan; Lin, Hong Huang; DeLuca, David S.; Leppanen, Scott; Milford, Edgar L.; Reinherz, Ellis L.; Brusic, Vladimir (Frontiers Media S.A., 2014)
      Human leukocyte antigens (HLA) are important biomarkers because multiple diseases, drug toxicity, and vaccine responses reveal strong HLA associations. Current clinical HLA typing is an elimination process requiring serial ...

    • Human microbiome science: vision for the future, Bethesda, MD, July 24 to 26, 2013 

      Ravel, Jacques; Blaser, Martin J; Braun, Jonathan; Brown, Eric; Bushman, Frederic D; Chang, Eugene B; Davies, Julian; Dewey, Kathryn G; Dinan, Timothy; Dominguez-Bello, Maria; Erdman, Susan E; Finlay, B Brett; Garrett, Wendy S; Huffnagle, Gary B; Huttenhower, Curtis; Jansson, Janet; Jeffery, Ian B; Jobin, Christian; Khoruts, Alexander; Kong, Heidi H; Lampe, Johanna W; Ley, Ruth E; Littman, Dan R; Mazmanian, Sarkis K; Mills, David A; Neish, Andrew S; Petrof, Elaine; Relman, David A; Rhodes, Rosamond; Turnbaugh, Peter J; Young, Vincent B; Knight, Rob; White, Owen (BioMed Central, 2014)
      A conference entitled ‘Human microbiome science: Vision for the future’ was organized in Bethesda, MD from July 24 to 26, 2013. The event brought together experts in the field of human microbiome research and aimed at ...

    • Human middle longitudinal fascicle: segregation and behavioral-clinical implications of two distinct fiber connections linking temporal pole and superior temporal gyrus with the angular gyrus or superior parietal lobule using multi-tensor tractography 

      Makris, Nikolaos; Preti, M. G.; Wassermann, D.; Rathi, Yogesh; Papadimitriou, G. M.; Yergatian, C.; Dickerson, Bradford Clark; Shenton, Martha Elizabeth; Kubicki, Marek R. (Springer Science + Business Media, 2013)
      The middle longitudinal fascicle (MdLF) is a major fiber connection running principally between the superior temporal gyrus and the parietal lobe, neocortical regions of great biological and clinical interest. Although one ...

    • Human middle longitudinal fascicle: variations in patterns of anatomical connections 

      Makris, Nikolaos; Preti, M. G.; Asami, T.; Pelavin, P.; Campbell, B.; Papadimitriou, G. M.; Kaiser, J.; Baselli, G.; Westin, Carl-Fredrik; Shenton, Martha Elizabeth; Kubicki, Marek R. (Springer Science + Business Media, 2012)
      Based on high-resolution diffusion tensor magnetic resonance imaging (DTI) tractographic analyses in thirty-nine healthy adult subjects we derived patterns of connections and measures of volume and biophysical parameters, ...

    • Human Milk as a Source of Methylmercury Exposure in Infants 

      Grandjean, Philippe; Jørgensen, PJ; Weihe, Pal (Environmental Health Perspectives, 1994)
      As methylmercury is excreted in human milk and infants are particularly susceptible to toxicity due to this compound, the purpose of this study was to evaluate the possible transfer of methylmercury to infants via ...

    • Human Milk Proresolving Mediators Stimulate Resolution of Acute Inflammation 

      Arnardottir, Hildur; Orr, Sarah K; Dalli, Jesmond; Serhan, Charles N (2015)
      Human milk contains nutrients and bioactive products relevant to infant development and immunological protection. Here, we investigated the pro-resolving properties of milk using human milk lipid mediator isolates (HLMI) ...

    • A Human Model of Small Fiber Neuropathy to Study Wound Healing 

      Illigens, Ben Min-Woo; Gibbons, Christopher H (Public Library of Science, 2013)
      The aim of this study was to develop a human model of acute wound healing that isolated the effects of small fiber neuropathy on the healing process. Twenty-five healthy subjects had the transient receptor vanilloid 1 ...

    • Human NK Cell Subset Functions Are Differentially Affected by Adipokines 

      Huebner, Lena; Engeli, Stefan; Wrann, Christiane D.; Goudeva, Lilia; Laue, Tobias; Kielstein, Heike (Public Library of Science, 2013)
      Background: Obesity is a risk factor for various types of infectious diseases and cancer. The increase in adipose tissue causes alterations in both adipogenesis and the production of adipocyte-secreted proteins (adipokines). ...

    • Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques 

      Santra, Sampa; Tomaras, Georgia D.; Warrier, Ranjit; Nicely, Nathan I.; Liao, Hua-Xin; Pollara, Justin; Liu, Pinghuang; Alam, S. Munir; Zhang, Ruijun; Cocklin, Sarah L.; Shen, Xiaoying; Duffy, Ryan; Xia, Shi-Mao; Schutte, Robert J.; Pemble IV, Charles W.; Dennison, S. Moses; Li, Hui; Chao, Andrew; Vidnovic, Kora; Evans, Abbey; Klein, Katja; Kumar, Amit; Robinson, James; Landucci, Gary; Forthal, Donald N.; Montefiori, David C.; Kaewkungwal, Jaranit; Nitayaphan, Sorachai; Pitisuttithum, Punnee; Rerks-Ngarm, Supachai; Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.; Soderberg, Kelly A.; Giorgi, Elena E.; Blair, Lily; Korber, Bette T.; Moog, Christiane; Shattock, Robin J.; Letvin, Norman L.; Schmitz, Joern E.; Moody, M. A.; Gao, Feng; Ferrari, Guido; Shaw, George M.; Haynes, Barton F. (Public Library of Science, 2015)
      HIV-1 mucosal transmission begins with virus or virus-infected cells moving through mucus across mucosal epithelium to infect CD4+ T cells. Although broadly neutralizing antibodies (bnAbs) are the type of HIV-1 antibodies ...

    • Human ovarian cancer stem/progenitor cells are stimulated by doxorubicin but inhibited by Mullerian inhibiting substance 

      Meirelles, K.; Benedict, Lance Mitchell; Dombkowski, D.; Pepin, David; Preffer, Frederic Ira; Teixeira, J; Tanwar, P; Young, Robert Henry; MacLaughlin, D. T.; Donahoe, Patricia; Wei, X. (Proceedings of the National Academy of Sciences, 2012)
      Women with late-stage ovarian cancer usually develop chemotherapeutic-resistant recurrence. It has been theorized that a rare cancer stem cell, which is responsible for the growth and maintenance of the tumor, is also ...

    • Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase 

      Kamil, Jeremy P.; Hume, Adam J.; Jurak, Igor; Münger, Karl; Kalejta, Robert F.; Coen, Donald M. (National Academy of Sciences, 2009)
      Several different families of DNA viruses encode proteins that inactivate the cellular retinoblastoma tumor suppressor protein (pRb), which normally functions to bind E2F transcription factors and restrict expression of ...

    • Human Papillomavirus 18 E6 Inhibits Phosphorylation of p53 Expressed in HeLa Cells 

      Ajay, Amrendra K; Meena, Avtar S; Bhat, Manoj K (BioMed Central, 2012)
      Background: In HPV infected cells p53 function is abrogated by E6 and even ectopically expressed p53 is unable to perform tumor suppressor functions. In addition to facilitating its degradation, E6 may also inhibit p53 ...

    • Human Papillomavirus E6 Triggers Upregulation of the Antiviral and Cancer Genomic DNA Deaminase APOBEC3B 

      Vieira, Valdimara C.; Leonard, Brandon; White, Elizabeth A.; Starrett, Gabriel J.; Temiz, Nuri A.; Lorenz, Laurel D.; Lee, Denis; Soares, Marcelo A.; Lambert, Paul F.; Howley, Peter M.; Harris, Reuben S. (American Society of Microbiology, 2014)
      ABSTRACT Several recent studies have converged upon the innate immune DNA cytosine deaminase APOBEC3B (A3B) as a significant source of genomic uracil lesions and mutagenesis in multiple human cancers, including those of ...

    • Human papillomavirus infection in Rwanda at the moment of implementation of a national HPV vaccination programme 

      Ngabo, Fidele; Franceschi, Silvia; Baussano, Iacopo; Umulisa, M. Chantal; Snijders, Peter J. F.; Uyterlinde, Anne M.; Lazzarato, Fulvio; Tenet, Vanessa; Gatera, Maurice; Binagwaho, Agnes; Clifford, Gary M. (BioMed Central, 2016)
      Background: Cervical cancer is the most common female cancer in Rwanda that, in 2011, became the first African country to implement a national vaccination programme against human papillomavirus (HPV). Methods: To provide ...

    • Human Papillomavirus Type 16 E7 Oncoprotein Associates with the Centrosomal Component γ-Tubulin 

      Nguyen, Christine L.; Eichwald, Catherine; Nibert, Max L.; Münger, Karl (American Society for Microbiology, 2007)
      Expression of a high-risk human papillomavirus (HPV) E7 oncoprotein is sufficient to induce aberrant centrosome duplication in primary human cells. The resulting centrosome-associated mitotic abnormalities have been linked ...