Browsing Harvard Medical School by Title

Now showing items 8381-8400 of 18428

    • IDH1 and IDH2 Mutation Studies in 1473 Patients with Chronic-, Fibrotic- or Blast-Phase Essential Thrombocythemia, Polycythemia Vera or Myelofibrosis 

      Tefferi, A; Lasho, T L; Abdel-Wahab, O; Guglielmelli, P; Caramazza, D; Pieri, L; Finke, C M; Kilpivaara, O; Mai, M; Gilliland, Dwight; Pardanani, A; Vannucchi, A M; Patel, J.; Wadleigh, Martha; McClure, R. F.; Levine, Robert A. (Nature Publishing Group, 2010)
      In a multi-institutional collaborative project, 1473 patients with myeloproliferative neoplasms (MPN) were screened for isocitrate dehydrogenase 1 (IDH1)/IDH2 mutations: 594 essential thrombocythemia (ET), 421 polycythemia ...

    • Idiopathic Pericarditis and Pericardial Effusion in Children: Contemporary Epidemiology and Management 

      Shakti, Divya; Hehn, Rebecca; Gauvreau, Kimberly; Sundel, Robert P.; Newburger, Jane W. (Blackwell Publishing Ltd, 2014)
      Background: Multicenter studies on idiopathic or viral pericarditis and pericardial effusion (PPE) have not been reported in children. Colchicine use for PPE in adults is supported. We explored epidemiology and management ...

    • Idiopathic Peripheral Neuropathy Increases Fall Risk in a Population-Based Cohort Study of Older Adults 

      Riskowski, Jody Lea; Quach, Lien; Manor, Bradley David; Menz, Hylton B; Lipsitz, Lewis Arnold; Hannan, Marian T. (BioMed Central, 2012)

    • Idiopathic pulmonary fibrosis and coronary artery disease 

      Cicchitto, Gaetano; Musella, Valentina; Acitorio, Maria; Capuano, Nicola; Fiorenzano, Giuseppe; Owen, Caroline A; Polverino, Mario; Polverino, Francesca (BioMed Central, 2014)
      Idiopathic pulmonary fibrosis (IPF) is defined as a chronic fibrosing interstitial disease of unknown cause, limited to the lungs, and associated with the histopathologic and/or radiologic pattern of usual interstitial ...

    • Idiopathic Vitritis: An Elusive Complication of Boston Keratoprosthesis Surgery 

      Grassi, Christina Marsica (2015-05-13)
      Introduction: An idiopathic inflammation of the vitreous humor, “sterile vitritis,” has been observed in some keratoprosthesis recipients, typically months to years after implantation. Its etiology is unclear. Potential ...

    • IEX-1 deficiency induces browning of white adipose tissue and resists diet-induced obesity 

      Shahid, Mohd; Javed, Ammar A.; Chandra, David; Ramsey, Haley E.; Shah, Dilip; Khan, Mohammed F.; Zhao, Liping; Wu, Mei X. (Nature Publishing Group, 2016)
      Chronic inflammation plays a crucial role in the pathogenesis of obesity and insulin resistance. However, the primary mediators that affect energy homeostasis remain ill defined. Here, we report an unexpected role for ...

    • If it bleeds, it leads: separating threat from mere negativity 

      Kveraga, Kestutis; Boshyan, Jasmine; Adams, Reginald Jr.; Mote, Jasmine; Betz, Nicole; Ward, Noreen; Hadjikhani, Nouchine; Bar, Moshe; Barrett, Lisa (Oxford University Press, 2015)
      Most theories of emotion hold that negative stimuli are threatening and aversive. Yet in everyday experiences some negative sights (e.g. car wrecks) attract curiosity, whereas others repel (e.g. a weapon pointed in our ...

    • If It’s Not One Thing, It’s Another: An Inverse Relationship of Malignancy and Atherosclerotic Disease 

      Li, Matthew; Cima, Michael J; Milner, Danny A. (Public Library of Science, 2015)
      Atherosclerosis and malignancy are pervasive pathological conditions that account for the bulk of morbidity and mortality in developed countries. Our current understanding of the patholobiology of these fundamental disorders ...

    • If You Don’t Find It Often, You Often Don’t Find It: Why Some Cancers Are Missed in Breast Cancer Screening 

      Evans, Karla K.; Birdwell, Robyn L.; Wolfe, Jeremy M. (Public Library of Science, 2013)
      Mammography is an important tool in the early detection of breast cancer. However, the perceptual task is difficult and a significant proportion of cancers are missed. Visual search experiments show that miss (false negative) ...

    • The iFat1 transgene permits conditional endogenous n-3 PUFA enrichment both in vitro and in vivo 

      Clarke, Shannon E.; Kang, Jing X.; Ma, David W. L. (Springer International Publishing, 2014)
      Fat-1 transgenic mice, which endogenously convert n-6 PUFA to n-3 PUFA, are a useful tool in health research; however with this model timing of n-3 PUFA enrichment cannot be directly controlled. To add such capability, the ...

    • The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus 

      Brass, Abraham L.; Huang, I-Chueh; Benita, Yair; John, Sinu P.; Krishnan, Manoj N.; Feeley, Eric M.; Ryan, Bethany J.; Weyer, Jessica L.; van der Weyden, Louise; Fikrig, Erol; Adams, David J.; Farzan, Michael; Elledge, Stephen; Xavier, Ramnik (Elsevier BV, 2009-12)
      Influenza viruses exploit host cell machinery to replicate, resulting in epidemics of respiratory illness. In turn, the host expresses antiviral restriction factors to defend against infection. To find host cell modifiers ...

    • IFITM Proteins Restrict Antibody-Dependent Enhancement of Dengue Virus Infection 

      Chan, Ying Kai; Huang, I-Chueh; Farzan, Michael (Public Library of Science, 2012)
      Interferon-inducible transmembrane (IFITM) proteins restrict the entry processes of several pathogenic viruses, including the flaviviruses West Nile virus and dengue virus (DENV). DENV infects cells directly or via ...

    • IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells 

      Lee, Jaewoong; Robinson, Mark E.; Ma, Ning; Artadji, Dewan; Ahmed, Mohamed A.; Xiao, Gang; Sadras, Teresa; Deb, Gauri; Winchester, Janet; Cosgun, Kadriye Nehir; Geng, Huimin; Chan, Lai N.; Kume, Kohei; Miettinen, Teemu P.; Zhang, Ye; Nix, Matthew A.; Klemm, Lars; Chen, Chun Wei; Chen, Jianjun; Khairnar, Vishal; Wiita, Arun P.; Thomas-Tikhonenko, Andrei; Farzan, Michael; Jung, Jae U.; Weinstock, David; Manalis, Scott R.; Diamond, Michael S.; Vaidehi, Nagarajan; Müschen, Markus (Springer Science and Business Media LLC, 2020-11-04)
      Ifitm3 was previously identified as an endosomal protein that blocks viral infection1-3. Studying clinical cohorts of B-cell leukemia and lymphoma patients, we identified IFITM3 as a strong predictor of poor outcome. In ...

    • IFITM3 Inhibits Influenza a Virus Infection by Preventing Cytosolic Entry 

      Feeley, Eric M.; Sims, Jennifer S.; John, Sinu P.; Chin, Christopher R.; Pertel, Thomas; Chen, Li-Mei; Gaiha, Gaurav D.; Ryan, Bethany J.; Donis, Ruben O.; Elledge, Stephen J.; Brass, Abraham L.; Diamond, Michael S. (Public Library of Science, 2011)
      To replicate, viruses must gain access to the host cell's resources. Interferon (IFN) regulates the actions of a large complement of interferon effector genes (IEGs) that prevent viral replication. The interferon inducible ...

    • Ifitm3 Limits the Severity of Acute Influenza in Mice 

      Bailey, Charles C; Huang, I-Chueh; Kam, Christina; Farzan, Michael (Public Library of Science, 2012)
      Interferon-induced transmembrane (IFITM) proteins are a family of viral restriction factors that inhibit the entry processes of several pathogenic viruses, including influenza A virus (IAV), in vitro. Here we report that ...

    • IFITM3 restricts the morbidity and mortality associated with influenza 

      Everitt, Aaron R.; Clare, Simon; Pertel, Thomas Charles; John, Sinu P.; Wash, Rachael S.; Smith, Sarah E.; Chin, Christopher R.; Feeley, Eric M.; Sims, Jennifer S.; Adams, David J.; Wise, Helen M.; Kane, Leanne; Goulding, David A.; Digard, Paul; Anttila, Verneri; Baillie, J. Kenneth; Walsh, Tim S.; Hume, David A.; Palotie, Aarno; Xue, Yali; Colonna, Vincenza; Tyler-Smith, Chris; Dunning, Jake; Gordon, Stephen B.; Smyth, Rosalind L.; Openshaw, Peter; Dougan, Gordon; Brass, Abraham L.; Kellam, Paul (2013)

    • IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure 

      Lu, Lenette; Smith, Malisa; Yu, Krystle K. Q.; Luedemann, Corinne; Suscovich, Todd; Grace, Patricia; Cain, Adam; Yu, Wen-Han; McKitrick, Tanya; Lauffenburger, Douglas; Cummings, Richard; Mayanja-Kizza, Harriet; Hawn, Thomas R.; Boom, W. Henry; Stein, Catherine M.; Fortune, Sarah; Seshadri, Chetan; Alter, Galit (Springer Science and Business Media LLC, 2019-05-20)
      Exposure to Mycobacterium tuberculosis (Mtb) results in heterogeneous clinical outcomes including primary progressive tuberculosis and latent Mtb infection (LTBI). Mtb infection is identified using the tuberculin skin test ...

    • IFNL3 (IL28B) favorable genotype escapes hepatitis C virus-induced microRNAs and mRNA decay 

      McFarland, Adelle P.; Horner, Stacy M.; Jarret, Abigail; Joslyn, Rochelle C.; Bindewald, Eckart; Shapiro, Bruce A.; Delker, Don A.; Hagedorn, Curt; Carrington, Mary; Gale, Michael; Savan, Ram (2014)
      The IFNL3 (IL28B) gene has received immense attention in the hepatitis C virus (HCV) field as multiple independent genome-wide association studies identified a strong association between polymorphisms near the IFNL3 gene ...

    • IFNγ Inhibits the Cytosolic Replication of Shigella flexneri via the Cytoplasmic RNA Sensor RIG-I 

      Jehl, Stephanie P.; Nogueira, Catarina V.; Zhang, Xuqing; Starnbach, Michael N. (Public Library of Science, 2012)
      The activation of host cells by interferon gamma (IFNγ) is essential for inhibiting the intracellular replication of most microbial pathogens. Although significant advances have been made in identifying IFNγ-dependent host ...

    • The IFT-A Complex Regulates Shh Signaling through Cilia Structure and Membrane Protein Trafficking 

      Liem, Karel F., Jr.; Ashe, Alyson; He, Mu; Satir, Peter; Moran, Jennifer; Beier, David Randolph; Wicking, Carol; Anderson, Kathryn V. (The Rockefeller University Press, 2012)
      Two intraflagellar transport (IFT) complexes, IFT-A and IFT-B, build and maintain primary cilia and are required for activity of the Sonic hedgehog (Shh) pathway. A weak allele of the IFT-A gene, Ift144, caused subtle ...