Now showing items 8658-8677 of 18424

    • Impact of Universal Health Insurance Coverage in Thailand on Sales and Market Share of Medicines for Non-Communicable Diseases: an Interrupted Time Series Study 

      Garabedian, Laura Faden; Ross-Degnan, Dennis; Ratanawijitrasin, Sauwakon; Stephens, Peter; Wagner, Anita Katharina (BMJ Publishing Group, 2012)
      Objective: In 2001, Thailand implemented the Universal Coverage Scheme (UCS), a public insurance system that aimed to achieve universal access to healthcare, including essential medicines, and to influence primary care ...
    • Impact of virtual case-based collaborative learning compared to virtual lectures to teaching critical appraisal of medical literature in fourth-year medical students, a pilot mixed methods study. 

      Esparza Perez, Ramiro Israel (2021-07-19)
      Introduction: Evidence-based medicine (EBM) is a practice that allows clinicians to implement the best available evidence for our patients. However, there is no best way to teach EBM, and multiple strategies have been ...
    • The impact of visual acuity on age-related differences in neural markers of early visual processing 

      Daffner, Kirk R.; Haring, Anna E.; Alperin, Brittany R.; Zhuravleva, Tatyana Y.; Mott, Katherine K.; Holcomb, Phillip J. (Elsevier BV, 2013)
      The extent to which age-related differences in neural markers of visual processing are influenced by changes in visual acuity has not been systematically investigated. Studies often indicate that their subjects had normal ...
    • Impact of Vitamin D and Asthma on Preeclampsia Development: A Sequential Evidence-Based Approach to Genomic Analysis 

      Mirzakhani, Hooman (2015-09-29)
      The biologic evidence regarding the role for vitamin D in immunologic mechanisms and reproductive outcomes is strong. Epidemiologic studies have shown a high prevalence of vitamin D deficiency among pregnant women, especially ...
    • The impact of weather changes on air quality and health in the United States in 1994–2012 

      Jhun, Iny; Coull, Brent A; Schwartz, Joel; Hubbell, Bryan; Koutrakis, Petros (2016)
      Air quality is heavily influenced by weather conditions. In this study, we assessed the impact of long-term weather changes on air quality and health in the US during 1994–2012. We quantified past weather-related increases, ...
    • The impact of “early” versus “late” initiation of renal replacement therapy in critical care patients with acute kidney injury: a systematic review and evidence synthesis 

      Wierstra, Benjamin T.; Kadri, Sameer; Alomar, Soha; Burbano, Ximena; Barrisford, Glen W.; Kao, Raymond L. C. (BioMed Central, 2016)
      Background: The optimal timing of initiating renal replacement therapy (RRT) in critical illness complicated by acute kidney injury (AKI) is not clearly established. Trials completed on this topic have been marked by ...
    • Impact on Mortality and Cancer Incidence Rates of Using Random Invitation from Population Registers for Recruitment to Trials 

      Burnell, Matthew; Gentry-Maharaj, Aleksandra; Ryan, Andy; Apostolidou, Sophia; Habib, Mariam; Kalsi, Jatinderpal; Parmar, Mahesh; Seif, Mourad W; Amso, Nazar N; Godfrey, Keith; Oram, David; Herod, Jonathan; Williamson, Karin; Jenkins, Howard; Mould, Tim; Woolas, Robert; Murdoch, John; Dobbs, Stephen; Leeson, Simon; Cruickshank, Derek; Campbell, Stuart; Fallowfield, Lesley; Jacobs, Ian; Menon, Usha; Skates, Steven J. (BioMed Central, 2011)
      Background: Participants in trials evaluating preventive interventions such as screening are on average healthier than the general population. To decrease this ‘healthy volunteer effect’ (HVE) women were randomly invited ...
    • Impact papers on aging in 2009 

      Blagosklonny, Mikhail V.; Campisi, Judy; Bartke, Andrzej; Blasco, Maria A.; Bonner, William M.; Bohr, Vilhelm A.; Jr, Robert M. Brosh; Brunet, Anne; Donehower, Lawrence A.; Finch, Caleb E.; Finkel, Toren; Gorospe, Myriam; Gudkov, Andrei V.; Hall, Michael N.; Hekimi, Siegfried; Helfand, Stephen L.; Karlseder, Jan; Kenyon, Cynthia; Kroemer, Guido; Longo, Valter; Nussenzweig, Andre; Osiewacz, Heinz D.; Peeper, Daniel S.; Rando, Thomas A.; Rudolph, K Lenhard; Sassone-Corsi, Paolo; Serrano, Manuel; Sharpless, Norman E.; Skulachev, Vladimir P.; Tower, John; Verdin, Eric; Vijg, Jan; Sinclair, David Andrew; DePinho, Ronald A.; Tilly, Jonathan Lee (Impact Journals LLC, 2010)
      The editorial board of Aging reviews research papers published in 2009, which they believe have or will have a significant impact on aging research. Among many others, the topics include genes that accelerate aging or in ...
    • Impacts of elevated atmospheric CO2 on nutrient content of important food crops 

      Dietterich, Lee H.; Zanobetti, Antonella; Kloog, Itai; Huybers, Peter; Leakey, Andrew D. B.; Bloom, Arnold J.; Carlisle, Eli; Fernando, Nimesha; Fitzgerald, Glenn; Hasegawa, Toshihiro; Holbrook, N. Michele; Nelson, Randall L.; Norton, Robert; Ottman, Michael J.; Raboy, Victor; Sakai, Hidemitsu; Sartor, Karla A.; Schwartz, Joel; Seneweera, Saman; Usui, Yasuhiro; Yoshinaga, Satoshi; Myers, Samuel S. (Nature Publishing Group, 2015)
      One of the many ways that climate change may affect human health is by altering the nutrient content of food crops. However, previous attempts to study the effects of increased atmospheric CO2 on crop nutrition have been ...
    • Impacts of Fluid Dynamics Simulation in Study of Nasal Airflow Physiology and Pathophysiology in Realistic Human Three-Dimensional Nose Models 

      Wang, De Yun; Lee, Heow Peuh; Gordon, Bruce R. (Korean Society of Otorhinolaryngology-Head and Neck Surgery, 2012)
      During the past decades, numerous computational fluid dynamics (CFD) studies, constructed from CT or MRI images, have simulated human nasal models. As compared to rhinomanometry and acoustic rhinometry, which provide ...
    • Impacts of Temperature and its Variability on Mortality in New England 

      Shi, Liuhua; Kloog, Itai; Zanobetti, Antonella; Liu, Pengfei; Schwartz, Joel D. (2015)
      Rapid buildup of greenhouse gases is expected to increase the Earth surface mean temperature, with unclear effects on temperature variability1–3. This adds urgency to better understand the direct effects of the changing ...
    • Impaired autophagy in mouse embryonic fibroblasts null for Krüppel-like Factor 4 promotes DNA damage and increases apoptosis upon serum starvation 

      Liu, Changchang; DeRoo, Elise P; Stecyk, Catherine; Wolsey, Margaret; Szuchnicki, Mateusz; Hagos, Engda G (BioMed Central, 2015)
      Background: Autophagy is a major cellular process by which cytoplasmic components such as damaged organelles and misfolded proteins are recycled. Although low levels of autophagy occur in cells under basal conditions, ...
    • Impaired Autophagy of an Intracellular Pathogen Induced by a Crohn's Disease Associated ATG16L1 Variant 

      Rioux, John D.; Gay, Nick; Kuballa, Petric; Huett, Alan Stephen; Daly, Mark Joseph; Xavier, Ramnik (Public Library of Science, 2008)
      The genetic risk factors predisposing individuals to the development of inflammatory bowel disease are beginning to be deciphered by genome-wide association studies. Surprisingly, these new data point towards a critical ...
    • Impaired Cerebral Autoregulation Is Associated with Brain Atrophy and Worse Functional Status in Chronic Ischemic Stroke 

      Aoi, Mikio C.; Hu, Kun; Lo, Men-Tzung; Selim, Magdy H.; Olufsen, Mette S.; Novak, Vera (Public Library of Science, 2012)
      Dynamic cerebral autoregulation (dCA) is impaired following stroke. However, the relationship between dCA, brain atrophy, and functional outcomes following stroke remains unclear. In this study, we aimed to determine whether ...
    • Impaired Cognitive Performance in Youth Athletes Exposed to Repetitive Head Impacts 

      Koerte, Inga Katharina; Nichols, Elizabeth; Tripodis, Yorghos; Schultz, Vivian; Lehner, Stefan; Igbinoba, Randy; Chuang, Alice Z.; Mayinger, Michael; Klier, Eliana M.; Muehlmann, Marc; Kaufmann, David; Lepage, Christian; Heinen, Florian; Schulte-Körne, Gerd; Zafonte, Ross Dennis; Shenton, Martha Elizabeth; Sereno, Anne B. (Mary Ann Liebert Inc, 2017)
      Worldwide, more than 22 million children and adolescents are exposed to repetitive head impacts (RHI) in soccer. Evidence indicates cumulative effects on brain structure, but it is not known whether exposure to RHI affects ...
    • Impaired Distal Thermoregulation in Diabetes and Diabetic Polyneuropathy 

      Rutkove, Seward Brian; Veves, Aristidis; Mitsa, Theophano; Nie, Rui; Fogerson, Patricia M.; Garmirian, Lindsay P.; Nardin, Rachel Austen (American Diabetes Association, 2009)
      Objective: To determine how thermoregulation of the feet is affected by diabetes and diabetic polyneuropathy in both wakefulness and sleep. Research Design and Methods: Normal subjects, diabetic subjects without neuropathy, ...
    • Impaired Function of Peripherally Induced Regulatory T Cells in Hosts at High Risk of Graft Rejection 

      Inomata, Takenori; Hua, Jing; Di Zazzo, Antonio; Dana, Reza (Nature Publishing Group, 2016)
      Regulatory T cells (Tregs) are crucial for allograft survival. Tregs can be divided into thymus-derived natural Tregs (tTregs) and peripherally-derived induced Tregs (pTregs). Here, we determine whether the suppressive ...
    • Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection 

      Kim, Arthur Yu-Shin; Schulze zur Wiesch, Julian; Kuntzen, Thomas; Timm, Joerg; Kaufmann, Daniel; Duncan, Jared E.; Jones, Andrea M.; Wurcel, Alysse G.; Davis, Benjamin Thomas; Gandhi, Rajesh Tim; Robbins, Gregory Kimball; Allen, Todd; Chung, Raymond Taeyong; Lauer, Georg; Walker, Bruce David (Public Library of Science, 2006)
      Background: Hepatitis C virus (HCV)-specific T cell responses are critical for spontaneous resolution of HCV viremia. Here we examined the effect of a lymphotropic virus, HIV-1, on the ability of coinfected patients to ...
    • Impaired infarct healing in atherosclerotic mice with Ly-6Chi monocytosis 

      Panizzi, Peter; Swirski, Filip; Figueiredo, Jose-Luiz; Waterman, Peter; Sosnovik, David; Aikawa, Elena; Libby, Peter; Pittet, Mikael; Weissleder, Ralph; Nahrendorf, Matthias (Elsevier, 2010)
      Objectives: he aim of this study was to test whether blood monocytosis in mice with atherosclerosis affects infarct healing.Background Monocytes are cellular protagonists of tissue repair, and their specific subtypes ...
    • Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells 

      Lafaille, Fabien G; Pessach, Itai M.; Zhang, Shen-Ying; Ciancanelli, Michael J.; Herman, Melina; Abhyankar, Avinash; Ying, Shui-Wang; Keros, Sotirios; Goldstein, Peter A.; Mostoslavsky, Gustavo; Ordovas-Montanes, Jose Manuel; Jouanguy, Emmanuelle; Plancoulaine, Sabine; Tu, Edmund; Elkabetz, Yechiel; Al-Muhsen, Saleh; Tardieu, Marc; Schlaeger, Thorsten M.; Daley, George Quentin; Abel, Laurent; Casanova, Jean-Laurent; Studer, Lorenz; Notarangelo, Luigi D. (2012)
      In the course of primary infection with herpes simplex virus 1 (HSV-1), children with inborn errors of TLR3 immunity are prone to HSV-1 encephalitis (HSE) 1–3. We tested the hypothesis that the pathogenesis of HSE involves ...