Browsing Harvard Medical School by Title

Now showing items 8977-8996 of 18428

    • Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell 

      Nishi, Mayuko; Akutsu, Hidenori; Kudoh, Ayumi; Kimura, Hirokazu; Yamamoto, Naoki; Umezawa, Akihiro; Lee, Sam W.; Ryo, Akihide (Impact Journals LLC, 2014)
      Cancer stem cells (CSCs) retain the capacity to propagate themselves through self-renewal and to produce heterogeneous lineages of cancer cells constituting the tumor. Novel drugs that target CSCs can potentially eliminate ...

    • An Induced Ets Repressor Complex Regulates Growth Arrest during Terminal Macrophage Differentiation 

      Klappacher, Günter W.; Lunyak, Victoria V.; Sykes, David Brian; Sawka-Verhelle, Dominique; Sage, Julien; Brard, Gyan; Ngo, Sally D.; Gangadharan, Denise; Jacks, Tyler; Kamps, Mark P.; Rose, David W.; Rosenfeld, Michael G.; Glass, Christopher K. (Elsevier BV, 2002)
      Defining the molecular mechanisms that coordinately regulate proliferation and differentiation is a central issue in development. Here, we describe a mechanism in which induction of the Ets repressor METS/PE1 links terminal ...

    • Induced Human Decidual NK-Like Cells Improve Utero-Placental Perfusion in Mice 

      Cavalli, Ricardo C.; Cerdeira, Ana Sofia; Pernicone, Elizabeth; Korkes, Henri A.; Burke, Suzanne D.; Rajakumar, Augustine; Thadhani, Ravi I.; Roberts, Drucilla J.; Bhasin, Manoj; Karumanchi, S. Ananth; Kopcow, Hernan D. (Public Library of Science, 2016)
      Decidual NK (dNK) cells, a distinct type of NK cell, are thought to regulate uterine spiral artery remodeling, a process that allows for increased blood delivery to the fetal-placental unit. Impairment of uterine spiral ...

    • Induced pluripotent stem cells: current progress and potential for regenerative medicine 

      Amabile, Giovanni; Meissner, Alexander (Elsevier BV, 2009)
      Lineage-restricted cells can be reprogrammed to a pluripotent state through overexpression of defined transcription factors. Here, we summarize recent progress in the direct reprogramming field and discuss data comparing ...

    • Induced Pluripotent Stem Cells: Development in the Ophthalmologic Field 

      Wu, Nan; Doorenbos, Marianne; Chen, Dong Feng (Hindawi Publishing Corporation, 2016)
      Human induced pluripotent stem cells (iPSCs) are a type of stem cells that can be derived from human somatic cells by introducing certain transcription factors. Induced pluripotent stem cells can divide indefinitely and ...

    • Inducible colitis-associated glycome capable of stimulating the proliferation of memory CD4+ T cells 

      Nishida, Atsushi; Nagahama, Kiyotaka; Imaeda, Hirotsugu; Ogawa, Atsuhiro; Lau, Cindy W.; Kobayashi, Taku; Hisamatsu, Tadakazu; Preffer, Frederic I.; Mizoguchi, Emiko; Ikeuchi, Hiroki; Hibi, Toshifumi; Fukuda, Minoru; Andoh, Akira; Blumberg, Richard S.; Mizoguchi, Atsushi (The Rockefeller University Press, 2012)
      Immune responses are modified by a diverse and abundant repertoire of carbohydrate structures on the cell surface, which is known as the glycome. In this study, we propose that a unique glycome that can be identified through ...

    • Inducible Histone K-to-M Mutations are Dynamic Tools to Probe the Physiological Role of Site-Specific Histone Methylation In Vitro and In Vivo 

      Brumbaugh, Justin; Kim, Ik Soo; Ji, Fei; Huebner, Aaron; Di Stefano, Bruno; Schwarz, Benjamin A.; Charlton, Jocelyn; Coffey, Amy; Choi, Jiho; Walsh, Ryan M.; Schindler, Jeffrey W.; Anselmo, Anthony; Meissner, Alexander; Sadreyev, Ruslan; Bernstein, Bradley; Hock, Hanno; Hochedlinger, Konrad (Springer Science and Business Media LLC, 2019-10-28)
      Development and differentiation are associated with profound changes to histone modifications, yet their in vivo function remains incompletely understood. Here, we generated mouse models expressing inducible histone H3 ...

    • Inducible interleukin-1 gene expression in human vascular smooth muscle cells. 

      Libby, Peter; Ordovas, J M; Birinyi, L K; Auger, K R; Dinarello, C A (American Society for Clinical Investigation, 1986)
      Interleukin-1 (IL-1) mediates many components of generalized host response to injury and may also contribute to local vascular pathology during immune or inflammatory responses. Because altered function of smooth muscle ...

    • Inducible Release of TRAIL Fusion Proteins from a Proapoptotic Form for Tumor Therapy 

      Shah, Khalid; Tung, Ching-Hsuan; Yang, Katherine; Weissleder, Ralph; Breakefield, Xandra O. (American Association for Cancer Research, 2004)
      Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively kill neoplastic cells and control of its activity could enhance tumor therapy. We have developed means to control the secretion of a novel ...

    • Inducing Cross-Clade Neutralizing Antibodies against HIV-1 by Immunofocusing 

      Humbert, Michael; Rasmussen, Robert Anthony; Ong, Helena; Kaiser, Fabian M. P.; Hu, Shiu-Lok; Ruprecht, Ruth Margrit (Public Library of Science, 2008)
      Background: Although vaccines are important in preventing viral infections by inducing neutralizing antibodies (nAbs), HIV-1 has proven to be a difficult target and escapes humoral immunity through various mechanisms. We ...

    • Induction and molecular signature of pathogenic TH17 cells 

      Lee, Youjin; Awasthi, Amit; Yosef, Nir; Quintana, Francisco Javier; Xiao, Sheng; Peters, Anneli; Wu, Chuan; Kleinewietfeld, Markus; Kunder, Sharon R.; Hafler, David A.; Sobel, Raymond A.; Regev, Aviv; Kuchroo, Vijay Kumar (2012)
      Interleukin 17 (IL-17)-producing TH17 cells are often present at the sites of tissue inflammation in autoimmune diseases, which has lead to the conclusion that TH17 are main drivers of autoimmune tissue injury. However, ...

    • Induction of Antioxidant and Heat Shock Protein Responses During Torpor in the Gray Mouse Lemur, Microcebus murinus 

      Wu, Cheng-Wei; Biggar, Kyle K.; Zhang, Jing; Tessier, Shannon N.; Pifferi, Fabien; Perret, Martine; Storey, Kenneth B. (Elsevier, 2015)
      A natural tolerance of various environmental stresses is typically supported by various cytoprotective mechanisms that protect macromolecules and promote extended viability. Among these are antioxidant defenses that help ...

    • Induction of Biogenic Magnetization and Redox Control by a Component of the Target of Rapamycin Complex 1 Signaling Pathway 

      Nishida, Keiji; Silver, Pamela A. (Public Library of Science, 2012)
      Most organisms are simply diamagnetic, while magnetotactic bacteria and migratory animals are among organisms that exploit magnetism. Biogenic magnetization not only is of fundamental interest, but also has industrial ...

    • Induction of Cytoprotective Pathways Is Central to the Extension of Lifespan Conferred by Multiple Longevity Pathways 

      Shore, David Eli; Carr, Christopher E.; Ruvkun, Gary B. (Public Library of Science, 2012)
      Many genetic and physiological treatments that extend lifespan also confer resistance to a variety of stressors, suggesting that cytoprotective mechanisms underpin the regulation of longevity. It has not been established, ...

    • Induction of Endothelial-Leukocyte Interaction by Interferon-\(\gamma\) Requires Coactivation of Nuclear Factor-\(\kappa\)B 

      De Caterina, Raffaele; Bourcier, Todd; Laufs, Ulrich; La Fata, Vito; Lazzerini, Guido; Neish, Andrew S.; Libby, Peter; Liao, James K. (American Heart Association, 2001)
      To determine whether nuclear factor (NF)-\(\kappa\) B is necessary to confer endothelial cell responsiveness to interferon (INF)-\(\gamma\) in terms of vascular cell adhesion molecule (VCAM)-1 expression and leukocyte ...

    • Induction of Erythroid Differentiation in Human Erythroleukemia Cells by Depletion of Malic Enzyme 2 

      Everett, Peter; Clish, Clary B.; Polymenis, Michael; Ren, Jian-Guo; Seth, Pankaj; Sukhatme, Vikas Pandurang (Public Library of Science, 2010)
      Malic enzyme 2 (ME2) is a mitochondrial enzyme that catalyzes the conversion of malate to pyruvate and CO2 and uses NAD as a cofactor. Higher expression of this enzyme correlates with the degree of cell de-differentiation. ...

    • Induction of IgG3 to LPS via Toll-Like Receptor 4 Co-Stimulation 

      Quintana, Francisco Javier; Solomon, Aderet; Cohen, Irun R.; Nussbaum, Gabriel (Public Library of Science, 2008)
      B-cells integrate antigen-specific signals transduced via the B-cell receptor (BCR) and antigen non-specific co-stimulatory signals provided by cytokines and CD40 ligation in order to produce IgG antibodies. Toll-like ...

    • Induction of pathogenic Th17 cells by inducible salt sensing kinase SGK1 

      Wu, Chuan; Yosef, Nir; Thalhamer, Theresa; Zhu, Chen; Xiao, Sheng; Kishi, Yasuhiro; Regev, Aviv; Kuchroo, Vijay (2013)
      Th17 cells are highly proinflammatory cells critical for clearing extracellular pathogens and for induction of multiple autoimmune diseases1. IL-23 plays a critical role in stabilizing and reinforcing the Th17 phenotype ...

    • Induction of Protective Genes Leads to Islet Survival and Function 

      Wang, Hongjun; Ferran, Christiane; Attanasio, Chiara; Calise, Fulvio; Otterbein, Leo E. (Hindawi Publishing Corporation, 2011)
      Islet transplantation is the most valid approach to the treatment of type 1 diabetes. However, the function of transplanted islets is often compromised since a large number of β cells undergo apoptosis induced by stress ...

    • Induction of Rapid Histone Degradation by the Cytotoxic T Lymphocyte Protease Granzyme A 

      Zhang, Dong; Pasternack, Mark S.; Beresford, Paul J.; Wagner, Ludwig; Greenberg, Arnold H.; Lieberman, Judy (American Society for Biochemistry and Molecular Biology, 2001)