Browsing Harvard Medical School by Title
Now showing items 9501-9520 of 18424
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The Invasive Cardiopulmonary Exercise Test
(Ovid Technologies (Wolters Kluwer Health), 2013-03-12) -
Invasive Fusariosis in the Voriconazole Era: Single-Center 13-Year Experience
(Oxford University Press, 2015)Background. Invasive fusariosis remains an aggressive, albeit infrequent infection in immunocompromised patients. Methods. We identified all cases of invasive fusariosis between January 2002 and December 2014. We recorded ... -
Invasive Systemic Infection After Hospital Treatment for Diabetic Foot Ulcer: Risk of Occurrence and Effect on Survival
(Oxford University Press (OUP), 2017-02-01)Background Diabetic foot ulcers (DFUs) threaten limbs and prompt hospitalization. After hospitalization, remote-site invasive systemic infection related to DFU (DFU-ISI) may occur. The characteristics of DFU-ISIs and their ... -
Inverse association between cancer and Alzheimer’s disease: results from the Framingham Heart Study
(BMJ Publishing Group Ltd., 2012)Objectives: To relate cancer since entry into the Framingham Heart Study with the risk of incident Alzheimer’s disease and to estimate the risk of incident cancer among participants with and without Alzheimer’s disease. ... -
Inverse Kinematics of Concentric Tube Steerable Needles
(IEEE, 2007-04)Prior papers have introduced steerable needles composed of precurved concentric tubes. The curvature and extent of these needles can be controlled by the relative rotation and translation of the individual tubes. Under ... -
Inverse Regulation of Inflammation and Mitochondrial Function in Adipose Tissue Defines Extreme Insulin Sensitivity in Morbidly Obese Patients
(American Diabetes Association, 2013)Obesity is associated with insulin resistance, a major risk factor for type 2 diabetes and cardiovascular disease. However, not all obese individuals are insulin resistant, which confounds our understanding of the mechanistic ... -
Investigating and Learning Lessons from Early Experiences of Implementing ePrescribing Systems into NHS Hospitals: A Questionnaire Study
(Public Library of Science (PLoS), 2013-01-15)Background ePrescribing systems have significant potential to improve the safety and efficiency of healthcare, but they need to be carefully selected and implemented to maximise benefits. Implementations in English hospitals ... -
Investigating essential gene function in Mycobacterium tuberculosis using an efficient CRISPR interference system
(Oxford University Press, 2016)Despite many methodological advances that have facilitated investigation of Mycobacterium tuberculosis pathogenesis, analysis of essential gene function in this slow-growing pathogen remains difficult. Here, we describe ... -
Investigating the association between obesity and asthma in 6- to 8-year-old Saudi children: a matched case–control study
(Nature Publishing Group, 2014)Background: Previous studies have demonstrated an association between obesity and asthma, but there remains considerable uncertainty about whether this reflects an underlying causal relationship. Aims: To investigate the ... -
Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study
(Public Library of Science, 2016)Background: C-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal. Methods and Findings: We performed Mendelian ... -
Investigating the cost-effectiveness of health information technologies: a systematic review protocol
(BMJ Publishing Group, 2013)Introduction: There is a need to develop new, more cost-effective models of healthcare and in this vein there is a considerable international interest in exploiting the potential offered by major developments in health ... -
Investigating the Effect of IgE and IgE-Mediated Mast Cell Activation on Dendritic Cell Function in Peanut Allergic Mice
(2018-05-16)Dendritic cells (DCs) are key cellular players in the body's innate immune surveillance of the extracellular environment and initiation of adaptive immune responses. They play a pivotal role in scavenging, capturing and ... -
Investigating the expression and function of nectin family members in anti-tumor immunity
(2021-07-19)CD112R (Pvrig), is a newly identified member of the nectin family, of which there are nine in total including TIGIT and TACTILE. Members of the nectin and nectin-like families have been shown to perform a wide range of ... -
Investigating the Impact of Chemotherapy Exposure on Peripheral Immune Responses for Patients with Ovarian Cancer
(2021-07-19)The current treatment of epithelial ovarian cancer (EOC) is based on surgical tumor debulking and platin-based chemotherapy. Neoadjuvant chemotherapy is used for initial tumor shrinkage before debulking surgery, but ... -
Investigating the Molecular Mechanisms of Action of Lenalidomide and Other Immunomodulatory Derivatives
(2018-05-15)Background: Thalidomide was first released as a sedative and anti-emetic by a German pharmaceutical company in the 1950s. After its withdrawal from the market due to severe teratogenicity, thalidomide and its novel iMiD ... -
Investigating the Neural Correlates of Voice versus Speech-Sound Directed Information in Pre-School Children
(Public Library of Science, 2014)Studies in sleeping newborns and infants propose that the superior temporal sulcus is involved in speech processing soon after birth. Speech processing also implicitly requires the analysis of the human voice, which conveys ... -
Investigating the Role of RIO Protein Kinases in Caenorhabditis elegans
(Public Library of Science, 2015)RIO protein kinases (RIOKs) are a relatively conserved family of enzymes implicated in cell cycle control and ribosomal RNA processing. Despite their functional importance, they remain a poorly understood group of kinases ... -
Investigating the Role of the Host Multidrug Resistance Associated Protein Transporter Family in Burkholderia cepacia Complex Pathogenicity Using a Caenorhabditis elegans Infection Model
(Public Library of Science, 2015)This study investigated the relationship between host efflux system of the non-vertebrate nematode Caenorhabditis elegans and Burkholderia cepacia complex (Bcc) strain virulence. This is the first comprehensive effort to ... -
Investigating the Scope of Resident Patient Care Handoffs within Neurosurgery
(Public Library of Science (PLoS), 2012)Introduction: Handoffs are defined as verbal and written communications during patient care transitions. With the passage of recent ACMGE work hour rules further limiting the hours interns can spend in the hospital, many ... -
Investigation of a Candida guilliermondii Pseudo-Outbreak Reveals a Novel Source of Laboratory Contamination
(American Society for Microbiology, 2017-04)Candida guilliermondii was isolated from sterile specimens with increasing frequency over a several-month period despite a paucity of clinical evidence suggesting true Candida infections. However, a health care-associated ...