Browsing Harvard Medical School by Title

Now showing items 985-1004 of 18428

    • APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor 

      Ryu, Jiyoon; Galan, Amanda K.; Xin, Xiaoban; Dong, Feng; Abdul-Ghani, Muhammad A.; Zhou, Lijun; Wang, Changhua; Li, Cuiling; Holmes, Bekke M.; Sloane, Lauren B.; Austad, Steven N.; Guo, Shaodong; Musi, Nicolas; DeFronzo, Ralph A.; Deng, Chuxia; White, Morris F.; Liu, Feng; Dong, Lily Q. (2014)
      SUMMARY Binding of insulin receptor substrate proteins 1 and 2 (IRS1/2) to the insulin receptor (IR) is essential for the regulation of insulin sensitivity and energy homeostasis. However, the mechanism of IRS1/2 recruitment ...

    • Application of a synthetic human proteome to autoantigen discovery through PhIP-Seq 

      Larman, H. Benjamin; Zhao, Zhenming; Laserson, Uri; Li, Mamie Z.; Ciccia, Alberto; Gakidis, M. Angelica Martinez; Church, George M.; Kesari, Santosh; LeProust, Emily M.; Solimini, Nicole L.; Elledge, Stephen J. (2011)
      In this study, we improve on current autoantigen discovery approaches by creating a synthetic representation of the complete human proteome, the T7 “peptidome” phage display library (T7-Pep), and use it to profile the ...

    • Application of change point analysis to daily influenza-like illness emergency department visits 

      Kass-Hout, Taha A; Xu, Zhiheng; McMurray, Paul; Park, Soyoun; Buckeridge, David L; Brownstein, John S; Finelli, Lyn; Groseclose, Samuel L (BMJ Group, 2012)
      Background: The utility of healthcare utilization data from US emergency departments (EDs) for rapid monitoring of changes in influenza-like illness (ILI) activity was highlighted during the recent influenza A (H1N1) ...

    • Application of combined omics platforms to accelerate biomedical discovery in diabesity 

      Kurland, Irwin J; Accili, Domenico; Burant, Charles; Fischer, Steven M; Kahn, Barbara B; Newgard, Christopher B; Ramagiri, Suma; Ronnett, Gabriele V; Ryals, John A; Sanders, Mark; Shambaugh, Joe; Shockcor, John; Gross, Steven S (Blackwell Publishing Ltd, 2013)
      Diabesity has become a popular term to describe the specific form of diabetes that develops late in life and is associated with obesity. While there is a correlation between diabetes and obesity, the association is not ...

    • An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene Interactions on risk of myocardial infarction: The importance of model validation 

      Coffey, Christopher S.; Hebert, Patricia R; Ritchie, Marylyn D; Krumholz, Harlan M; Gaziano, John Michael; Ridker, Paul M.; Brown, Nancy J; Vaughan, Douglas E; Moore, Jason H (BioMed Central, 2004)
      Background: To examine interactions among the angiotensin converting enzyme (ACE) insertion/deletion, plasminogen activator inhibitor-1 (PAI-1) 4G/5G, and tissue plasminogen activator (t-PA) insertion/deletion gene ...

    • The Application of DTI to Investigate White Matter Abnormalities in Schizophrenia 

      Kubicki, Marek R.; Westin, Carl-Fredrik; McCarley, Robert William; Shenton, Martha Elizabeth (Wiley-Blackwell, 2005)
      Schizophrenia is a serious and disabling mental disorder that affects approximately 1% of the general population, with often devastating effects on the psychological and financial resources of the patient, family, and ...

    • Application of futility analysis to refine jitter recordings in myasthenia gravis 

      Narayanaswami, Pushpa; Pantoja-Galicia, Norberto; Betensky, Rebecca Aubrey; Rutkove, Seward Brian (Wiley-Blackwell, 2012)
      Introduction The current practice of single fiber electromyography (SFEMG) requires that 20 fiber pairs with normal jitter be collected to exclude myasthenia gravis (MG). We applied principles of futility analysis from ...

    • Application of In Vivo Induced Antigen Technology (IVIAT) to Bacillus anthracis 

      Peppercorn, Amanda; Young, John S.; Drysdale, Melissa; Baresch, Andrea; Bikowski, Margaret V.; Ashford, David A.; Quinn, Conrad P.; Handfield, Martin; Hillman, Jeffrey D.; Lyons, C. Rick; Koehler, Theresa M.; Sonenshein, Abraham L.; Rollins, Sean McKenzie; Calderwood, Stephen Beaven; Ryan, Edward Thomas (Public Library of Science, 2008)
      In vivo induced antigen technology (IVIAT) is an immuno-screening technique that identifies bacterial antigens expressed during infection and not during standard in vitro culturing conditions. We applied IVIAT to Bacillus ...

    • The Application of Optical Coherence Tomography in Musculoskeletal Disease 

      Rashidifard, Christopher; Vercollone, Christopher; Martin, Scott David; Liu, Bin; Brezinski, Mark Edward (Hindawi Publishing Corporation, 2013)
      Many musculoskeletal disorders (MDs) are associated with irreversible bone and cartilage damage; this is particularly true for osteoarthritis (OA). Therefore, a clinical need exists for modalities which can detect OA and ...

    • Application of Palladium-Mediated 18F-Fluorination to PET Radiotracer Development: Overcoming Hurdles to Translation 

      Kamlet, Adam; Neumann, Constanze Nicole; Lee, Eunsung; Carlin, Stephen M.; Moseley, Christian K.; Stephenson, Nickeisha A; Hooker, Jacob M; Ritter, Tobias (Public Library of Science, 2013)
      New chemistry methods for the synthesis of radiolabeled small molecules have the potential to impact clinical positron emission tomography (PET) imaging, if they can be successfully translated. However, progression of ...

    • Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique? 

      Lee, Han Hee; Choi, Myung-Gyu; Hasan, Tayyaba (The Korean Association of Internal Medicine, 2017)
      Photodynamic therapy (PDT) is a promising therapeutic modality that involves the administration of a photosensitizer followed by local illumination with a specific wavelength of light in the presence of oxygen. PDT is ...

    • Application of Pipeline Embolization Device for Iatrogenic Pseudoaneurysms of the Extracranial Vertebral Artery: A Case Report and Systematic Review of the Literature 

      Dolati, Parviz; Eichberg, Daniel G; Thomas, Ajith; Ogilvy, Christopher S (Cureus, 2015)
      Traumatic pseudoaneurysms of the vertebral artery (VA) are uncommon vascular lesions and definitive management is often challenging. Between 0% and 8% of craniocervical fusions are complicated by VA injury. In these cases, ...

    • Application of Respondent Driven Sampling to Collect Baseline Data on FSWs and MSM for HIV Risk Reduction Interventions in Two Urban Centres in Papua New Guinea 

      Yeka, William; Maibani–Michie, Geraldine; Prybylski, Dimitri; Colby, Donn J (Kluwer Academic Publishers-Plenum Publishers, 2006)
      The need to obtain unbiased information among hard–to-reach and hidden populations for behavioural and biological surveillance, epidemiological studies, and intervention program evaluations has led researchers to search ...

    • Applications and Limitations of Inflammatory Biomarkers for Studies on Neurocognitive Impairment in HIV Infection 

      Cassol, Edana; Misra, Vikas; Morgello, Susan; Gabuzda, Dana (Springer US, 2013)
      Despite reduced prevalence of severe forms of HIV-associated neurocognitive disorders (HAND) on current antiretroviral therapy (ART) regimens, milder forms of neurocognitive impairment (NCI) remain prevalent in HIV-infected ...

    • Applications of Computational Fluid Dynamics in Cardiovascular Disease 

      Rigatelli, Gianluca; Zuin, Marco; Agarwal, Sarthak; Nguyen, Vivian; Nguyen, Cardy; Agarwal, Sanyaa; Nguyen, Thach (Tan Tao University, 2022-10-09)
      Computational fluid dynamics (CFD), alone or coupled with the most advanced imaging tools, allows for the assessment of blood flow patterns in cardiovascular disease to both understand their pathophysiology and anticipate ...

    • Applications of High-Throughput RNA Interference Screens to Problems in Cell and Developmental Biology 

      Perrimon, Norbert; Mathey-Prevot, Bernard (Genetics Society of America, 2007)
      RNA interference (RNAi) in tissue culture cells has emerged as an excellent methodology for identifying gene functions systematically and in an unbiased manner. Here, we describe how RNAi high-throughput screening (HTS) ...

    • Applied statistical training to strengthen analysis and health research capacity in Rwanda 

      Thomson, Dana R.; Semakula, Muhammed; Hirschhorn, Lisa R.; Murray, Megan; Ndahindwa, Vedaste; Manzi, Anatole; Mukabutera, Assumpta; Karema, Corine; Condo, Jeanine; Hedt-Gauthier, Bethany (BioMed Central, 2016)
      Background: To guide efficient investment of limited health resources in sub-Saharan Africa, local researchers need to be involved in, and guide, health system and policy research. While extensive survey and census data ...

    • Applying a free-water correction to diffusion imaging data uncovers stress-related neural pathology in depression 

      Bergamino, Maurizio; Pasternak, Ofer; Farmer, Madison; Shenton, Martha E.; Paul Hamilton, J. (Elsevier, 2015)
      Diffusion tensor imaging (DTI) holds promise for developing our understanding of white-matter pathology in major depressive disorder (MDD). Variable findings in DTI-based investigations of MDD, however, have thwarted ...

    • Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper 

      Lener, Thomas; Gimona, Mario; Aigner, Ludwig; Börger, Verena; Buzas, Edit; Camussi, Giovanni; Chaput, Nathalie; Chatterjee, Devasis; Court, Felipe A.; del Portillo, Hernando A.; O'Driscoll, Lorraine; Fais, Stefano; Falcon-Perez, Juan M.; Felderhoff-Mueser, Ursula; Fraile, Lorenzo; Gho, Yong Song; Görgens, André; Gupta, Ramesh C.; Hendrix, An; Hermann, Dirk M.; Hill, Andrew F.; Hochberg, Fred; Horn, Peter A.; de Kleijn, Dominique; Kordelas, Lambros; Kramer, Boris W.; Krämer-Albers, Eva-Maria; Laner-Plamberger, Sandra; Laitinen, Saara; Leonardi, Tommaso; Lorenowicz, Magdalena J.; Lim, Sai Kiang; Lötvall, Jan; Maguire, Casey A.; Marcilla, Antonio; Nazarenko, Irina; Ochiya, Takahiro; Patel, Tushar; Pedersen, Shona; Pocsfalvi, Gabriella; Pluchino, Stefano; Quesenberry, Peter; Reischl, Ilona G.; Rivera, Francisco J.; Sanzenbacher, Ralf; Schallmoser, Katharina; Slaper-Cortenbach, Ineke; Strunk, Dirk; Tonn, Torsten; Vader, Pieter; van Balkom, Bas W. M.; Wauben, Marca; Andaloussi, Samir El; Théry, Clotilde; Rohde, Eva; Giebel, Bernd (Co-Action Publishing, 2015)
      Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different cell types and participate in physiological and pathophysiological processes. EVs mediate intercellular communication as cell-derived ...

    • Applying mathematical models to predict resident physician performance and alertness on traditional and novel work schedules 

      Klerman, Elizabeth B.; Beckett, Scott A.; Landrigan, Christopher P. (BioMed Central, 2016)
      Background: In 2011 the U.S. Accreditation Council for Graduate Medical Education began limiting first year resident physicians (interns) to shifts of ≤16 consecutive hours. Controversy persists regarding the effectiveness ...