Browsing Harvard Medical School by Title
Now showing items 9901-9920 of 18428
-
Liberation of desmosine and isodesmosine as amino acids from insoluble elastin by elastolytic proteases
(Elsevier BV, 2011)The development of atherosclerotic lesions and abdominal aortic aneurysms involves degradation and loss of extracellular matrix components, such as collagen and elastin. Releases of the elastin cross-links desmosine (DES) ... -
Life after prison: Exploring how best to support formerly incarcerated opioid users as they seek employment
(2021-06-25)The United States incarcerates 698 individuals per 100,000 residents – more per capita than any other nation (Wagner & Sawyer, 2020). An estimated 65% of incarcerated people have a substance use disorder (SUD) (NIDA, 2020). ... -
Life Course Socioeconomic Position and C-Reactive Protein: Mediating Role of Health-Risk Behaviors and Metabolic Alterations. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
(Public Library of Science, 2014)Background: Chronic inflammation has been postulated to be one mediating mechanism explaining the association between low socioeconomic position (SEP) and cardiovascular disease (CVD). We sought to examine the association ... -
Life Goals Collaborative Care for Patients With Bipolar Disorder and Cardiovascular Disease Risk
(American Psychiatric Publishing, 2012)Objectives The goal of this randomized controlled pilot study was to determine whether Life Goals Collaborative Care (LGCC) compared to enhanced treatment as usual, reduced cardiometabolic factors and improved outcomes ... -
Life Sciences and the web: a new era for collaboration
(Nature Publishing Group, 2008)The World Wide Web has revolutionized how researchers from various disciplines collaborate over long distances. This is nowhere more important than in the Life Sciences, where interdisciplinary approaches are becoming ... -
Life Without Perlecan Has Its Problems
(Rockefeller University Press, 1999-11-29)Perlecan plays an important tole in basement membranes and other extracellular matrices. Mice with a knockout gene for perlecan die at or before birth with severe defects in the brain, heart, and skeleton. -
Lifelong Learning in Medicine: A Two-Part Intervention to Encourage Self-Regulated Learning Skills Among First-Year Medical Students
(2022-05-13)Purpose: Students with developed self-regulated learning (SRL) skills demonstrate an ability to set individualized educational goals, select optimal learning strategies for reaching these goals and reflect on overall ... -
The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed
(BioMed Central, 2014)Specific vulnerability and degeneration of the dopaminergic neurons in the substantia nigra pars compacta of the midbrain is the pathological hallmark of Parkinson’s disease. A number of transcription factors regulate the ... -
Lifespan Extension Conferred by Endoplasmic Reticulum Secretory Pathway Deficiency Requires Induction of the Unfolded Protein Response
(Public Library of Science, 2014)Cells respond to accumulation of misfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR) signaling pathway. The UPR restores ER homeostasis by degrading misfolded proteins, ... -
The Lifespan Extension Effects of Resveratrol are Conserved in the Honey Bee and May Be Driven by a Mechanism Related to Caloric Restriction
(Impact Journals LLC, 2012)Our interest in healthy aging and in evolutionarily conserved mechanisms of lifespan extension prompted us to investigate whether features of age-related decline in the honey bee could be attenuated with resveratrol. ... -
Lifespan Regulation by Evolutionarily Conserved Genes Essential for Viability
(Public Library of Science, 2007)Evolutionarily conserved mechanisms that control aging are predicted to have prereproductive functions in order to be subject to natural selection. Genes that are essential for growth and development are highly conserved ... -
Lifestyle Counseling in Routine Care and Long-Term Glucose, Blood Pressure, and Cholesterol Control in Patients With Diabetes
(American Diabetes Association, 2012)OBJECTIVE In clinical trials, diet, exercise, and weight counseling led to short-term improvements in blood glucose, blood pressure, and cholesterol levels in patients with diabetes. However, little is known about the ... -
Lifestyle Interaction With Fat Mass and Obesity-Associated (FTO) Genotype and Risk of Obesity in Apparently Healthy U.S. Women
(American Diabetes Association, 2011)Objective: Variation in the fat mass and obesity-associated (FTO) gene is associated with obesity. The extent to which separate and combined effects of physical activity and caloric intake modify this association remains ... -
Lifestyle Intervention Improves Heart Rate Recovery from Exercise in Adults with Type 2 Diabetes: Results from the Look AHEAD Study
(Hindawi Publishing Corporation, 2012)The primary aims of this paper were (1) to evaluate the influence of intensive lifestyle weight loss and exercise intervention (ILI) compared with diabetes support and education (DSE) upon Heart Rate Recovery (HRR) from ... -
Lifestyle Medicine Education
(SAGE Publications, 2015)The actual causes of premature adult deaths, the preponderance of noncommunicable chronic diseases, and their associated costs are related to unhealthy behaviors, such as poor nutrition, physical inactivity, and tobacco ... -
Lifestyle‐Based Prediction Model for the Prevention of CVD: The Healthy Heart Score
(Blackwell Publishing Ltd, 2014)Background: Clinical practice focuses on the primary prevention of cardiovascular (CV) disease (CVD) through the modification and pharmacological treatment of elevated risk factors. Prediction models based on established ... -
Lifetime and 12-month prevalence of eating disorders amongst women in mid-life: a population-based study of diagnoses and risk factors
(BioMed Central, 2017)Background: Eating disorders (EDs) are common amongst women; however, no research has specifically investigated the lifetime/12-month prevalence of eating disorders amongst women in mid-life (i.e., fourth and fifth decade ... -
Lifetime Increased Cancer Risk in Mice Following Exposure to Clinical Proton Beam–Generated Neutrons
(Elsevier BV, 2014)Purpose To evaluate the lifespan and risk of cancer following whole-body exposure of mice to neutrons generated by a passively scattered clinical SOBP proton beam. Methods and Materials Three hundred young adult ... -
Lifetime Prevalence of Mental Disorders in Lebanon: First Onset, Treatment, and Exposure to War
(Public Library of Science, 2008)Background: There are no published data on national lifetime prevalence and treatment of mental disorders in the Arab region. Furthermore, the effect of war on first onset of disorders has not been addressed previously ... -
Lifetime Risk of Cardiovascular Disease Among Individuals With and Without Diabetes Stratified by Obesity Status in the Framingham Heart Study
(American Diabetes Association, 2008)Objective: We assessed the lifetime risk of cardiovascular disease (CVD) among individuals with and without obesity and diabetes. Research Design and Methods: Participants were drawn from the original and offspring cohorts ...