Now showing items 1-4 of 4

    • Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X 

      Cheng, Ching-Yu; Patterson, Nick; Haiman, Christopher A.; Harris, Tamara B.; Xing, Chao; John, Esther M.; Ambrosone, Christine B.; Brancati, Frederick L.; Coresh, Josef; Press, Michael F.; Parekh, Rulan S.; Klag, Michael J.; Meoni, Lucy A.; Hsueh, Wen-Chi; Fejerman, Laura; Pawlikowska, Ludmila; Jandorf, Lina H.; Bandera, Elisa V.; Ciupak, Gregory L.; Nalls, Michael A.; Akylbekova, Ermeg L.; Orwoll, Eric S.; Leak, Tennille S.; Miljkovic, Iva; Li, Rongling; Ursin, Giske; Bernstein, Leslie; Ardlie, Kristin; Taylor, Herman A.; Boerwinckle, Eric; Zmuda, Joseph M.; Henderson, Brian E.; Wilson, James G.; Kao, W. H. Linda; Tandon, Arti; Freedman, Matthew Lawrence; Patterson, Nicholas; Reich, David Emil (Public Library of Science, 2009)
    • A High-Density Admixture Scan in 1,670 African Americans with Hypertension 

      Patterson, Nick; McDonald, Gavin J; Haiman, Christopher A; Ardlie, Kristin; Henderson, Brian E; Henderson, Sean O; Leal, Suzanne M; Deo, Rahul Chandrakant; Tandon, Arti; Reich, David Emil (Public Library of Science, 2007)
      Hypertension (HTN) is a devastating disease with a higher incidence in African Americans than European Americans, inspiring searches for genetic variants that contribute to this difference. We report the results of a ...
    • Melanoma genome sequencing reveals frequent PREX2 mutations 

      Berger, Michael F.; Hodis, Eran; Heffernan, Timothy P.; Deribe, Yonathan Lissanu; Lawrence, Michael S.; Protopopov, Alexei; Ivanova, Elena; Watson, Ian R.; Nickerson, Elizabeth; Ghosh, Papia; Zhang, Hailei; Zeid, Rhamy; Ren, Xiaojia; Cibulskis, Kristian; Sivachenko, Andrey Y.; Wagle, Nikhil; Sucker, Antje; Sougnez, Carrie; Onofrio, Robert; Ambrogio, Lauren; Auclair, Daniel; Fennell, Timothy; Carter, Scott L.; Drier, Yotam; Stojanov, Petar; Singer, Meredith A.; Voet, Douglas; Jing, Rui; Saksena, Gordon; Barretina, Jordi; Ramos, Alex H.; Pugh, Trevor J.; Stransky, Nicolas; Parkin, Melissa; Winckler, Wendy; Mahan, Scott; Ardlie, Kristin; Baldwin, Jennifer; Wargo, Jennifer; Schadendorf, Dirk; Meyerson, Matthew; Gabriel, Stacey B.; Golub, Todd R.; Wagner, Stephan N.; Lander, Eric S.; Getz, Gad; Chin, Lynda; Garraway, Levi A. (2012)
      Melanoma is notable for its metastatic propensity, lethality in the advanced setting, and association with ultraviolet (UV) exposure early in life1. To obtain a comprehensive genomic view of melanoma, we sequenced the ...
    • Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design? 

      Heid, Iris M.; Huth, Cornelia; Loos, Ruth J. F.; Kronenberg, Florian; Adamkova, Vera; Anand, Sonia S.; Ardlie, Kristin; Biebermann, Heike; Bjerregaard, Peter; Boeing, Heiner; Bouchard, Claude; Ciullo, Marina; Cooper, Jackie A.; Corella, Dolores; Dina, Christian; Engert, James C.; Fisher, Eva; Francès, Francesc; Froguel, Philippe; Hebebrand, Johannes; Hegele, Robert A.; Hinney, Anke; Hoehe, Margret R.; Hubacek, Jaroslav A.; Humphries, Steve E.; Hunt, Steven C.; Illig, Thomas; Järvelin, Marjo-Riita; Kaakinen, Marika; Kollerits, Barbara; Krude, Heiko; Kumar, Jitender; Lange, Leslie A.; Langer, Birgit; Li, Shengxu; Luchner, Andreas; Meyre, David; Mohlke, Karen L.; Mooser, Vincent; Nebel, Almut; Nguyen, Thuy Trang; Paulweber, Bernhard; Perusse, Louis; Rankinen, Tuomo; Rosskopf, Dieter; Schreiber, Stefan; Sengupta, Shantanu; Sorice, Rossella; Suk, Anita; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Völzke, Henry; Vimaleswaran, Karani S.; Wareham, Nicholas J.; Waterworth, Dawn; Yusuf, Salim; Lindgren, Cecilia; McCarthy, Mark I.; Wichmann, H.-Erich; Allison, David B.; Hu, Frank B.; Qi, Lu; Lyon, Helen N; Lange, Christoph; Hirschhorn, Joel Naom; Laird, Nan M. (Public Library of Science, 2009)
      The INSIG2 rs7566605 polymorphism was identified for obesity (BMI≥30 kg/m2) in one of the first genome-wide association studies, but replications were inconsistent. We collected statistics from 34 studies (n = 74,345), ...