Browsing Harvard Medical School by Keyword "Applied Microbiology"

Now showing items 1-6 of 6

    • An Analysis of the Role of the Indigenous Microbiota in Cholesterol Gallstone Pathogenesis 

      Fremont-Rahl, Jacqueline J.; Ge, Zhongming; Umana, Carlos; Whary, Mark T.; Taylor, Nancy S.; Muthupalani, Sureshkumar; Carey, Martin C.; Fox, James G.; Maurer, Kirk J. (Public Library of Science, 2013)
      Background and Aims Cholesterol gallstone disease is a complex process involving both genetic and environmental variables. No information exists regarding what role if any the indigenous gastrointestinal microbiota may ...

    • Catecholate Siderophores Protect Bacteria from Pyochelin Toxicity 

      Adler, Conrado; Corbalán, Natalia S.; Seyedsayamdost, Mohammad; Pomares, María Fernanda; de Cristóbal, Ricardo E.; Clardy, Jon C.; Kolter, Roberto Guillermo; Vincent, Paula A. (Public Library of Science, 2012)
      Background: Bacteria produce small molecule iron chelators, known as siderophores, to facilitate the acquisition of iron from the environment. The synthesis of more than one siderophore and the production of multiple ...

    • Cloud-Enabled Microscopy and Droplet Microfluidic Platform for Specific Detection of Escherichia coli in Water 

      Golberg, Alexander; Linshiz, Gregory; Kravets, Ilia; Stawski, Nina; Hillson, Nathan J.; Yarmush, Martin L.; Marks, Robert S.; Konry, Tania (Public Library of Science, 2014)
      We report an all-in-one platform – ScanDrop – for the rapid and specific capture, detection, and identification of bacteria in drinking water. The ScanDrop platform integrates droplet microfluidics, a portable imaging ...

    • Cytological profiling: providing more haystacks for chemists' needles 

      Lorang, Janet; King, Randall Wharton (BioMed Central, 2005)
      Conventional high-throughput ‘chemical genetic’ screening seeks to identify small-molecule inhibitors of a specific protein or pathway. A recent study describes how unbiased screening of cellular morphology, followed by ...

    • Ivermectin Inhibits Growth of Chlamydia trachomatis in Epithelial Cells 

      Pettengill, Matthew A; Lam, Verissa W.; Ollawa, Ikechukwu; Marques-da-Silva, Camila; Ojcius, David M. (Public Library of Science, 2012)
      Ivermectin is currently approved for treatment of both clinical and veterinary infections by nematodes, including Onchocerca cervicalis in horses and Onchocerca volvulus in humans. However, ivermectin has never been shown ...

    • Structural Characterization of Pandoraea pnomenusa B-356 Biphenyl Dioxygenase Reveals Features of Potent Polychlorinated Biphenyl-Degrading Enzymes 

      Colbert, Christopher L.; Agar, Nathalie Marie Yvonne Rachel; Kumar, Pravindra; Chakko, Mathew N.; Sinha, Sangita C.; Powlowski, Justin B.; Eltis, Lindsay D.; Bolin, Jeffrey T. (Public Library of Science, 2013)
      The oxidative degradation of biphenyl and polychlorinated biphenyls (PCBs) is initiated in Pandoraea pnomenusa B-356 by biphenyl dioxygenase \((BPDO_{B356})\). \(BPDO_{B356}\), a heterohexameric \((αβ)_3\) Rieske oxygenase ...