Browsing Harvard Medical School by Keyword "BH3 mimetics"

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    • Defining specificity and on-target activity of BH3-mimetics using engineered B-ALL cell lines 

      Koss, Brian; Ryan, Jeremy; Budhraja, Amit; Szarama, Katherine; Yang, Xue; Bathina, Madhavi; Cardone, Michael H.; Nikolovska-Coleska, Zaneta; Letai, Anthony; Opferman, Joseph T. (Impact Journals LLC, 2016)
      One of the hallmarks of cancer is a resistance to the induction of programmed cell death that is mediated by selection of cells with elevated expression of anti-apoptotic members of the BCL-2 family. To counter this ...