Now showing items 1-8 of 8

    • Carotid Atherosclerosis, Cerebrospinal Fluid Pressure, and Retinal Vessel Diameters: The Asymptomatic Polyvascular Abnormalities in Community Study 

      Yang, Jing Yan; Yang, Xuan; Li, Yang; Xu, Jie; Zhou, Yong; Wang, An Xin; Gao, Xiang; Xu, Liang; Wu, Shou Ling; Wei, Wen Bin; Zhao, Xing Quan; Jonas, Jost B. (Public Library of Science, 2016)
      Purpose To assess relationships between carotid artery atherosclerosis and retinal arteriolar and venular diameters. Methods: The community-based longitudinal Asymptomatic Polyvascular Abnormalities Community Study (APAC) ...
    • Critical Endothelial Regulation by LRP5 during Retinal Vascular Development 

      Huang, Wei; Li, Qing; Amiry-Moghaddam, Mahmood; Hokama, Madoka; Sardi, Sylvia H.; Nagao, Masashi; Warman, Matthew L.; Olsen, Bjorn R. (Public Library of Science, 2016)
      Vascular abnormalities in the eye are the leading cause of many forms of inherited and acquired human blindness. Loss-of-function mutations in the Wnt-binding co-receptor LRP5 leads to aberrant ocular vascularization and ...
    • Early Cellular Changes in the Ascending Aorta and Myocardium in a Swine Model of Metabolic Syndrome 

      Saraf, Rabya; Huang, Thomas; Mahmood, Feroze; Owais, Khurram; Bardia, Amit; Khabbaz, Kamal R.; Liu, David; Senthilnathan, Venkatachalam; Lassaletta, Antonio D.; Sellke, Frank; Matyal, Robina (Public Library of Science, 2016)
      Background: Metabolic syndrome is associated with pathological remodeling of the heart and adjacent vessels. The early biochemical and cellular changes underlying the vascular damage are not fully understood. In this study, ...
    • Effect of Portal Glucose Sensing on Systemic Glucose Levels in SD and ZDF Rats 

      Pal, Atanu; Rhoads, David B.; Tavakkoli, Ali (Public Library of Science, 2016)
      Background: The global epidemic of Type-2-Diabetes (T2D) highlights the need for novel therapeutic targets and agents. Roux-en-Y-Gastric-Bypass (RYGB) is the most effective treatment. Studies investigating the mechanisms ...
    • Induced Human Decidual NK-Like Cells Improve Utero-Placental Perfusion in Mice 

      Cavalli, Ricardo C.; Cerdeira, Ana Sofia; Pernicone, Elizabeth; Korkes, Henri A.; Burke, Suzanne D.; Rajakumar, Augustine; Thadhani, Ravi I.; Roberts, Drucilla J.; Bhasin, Manoj; Karumanchi, S. Ananth; Kopcow, Hernan D. (Public Library of Science, 2016)
      Decidual NK (dNK) cells, a distinct type of NK cell, are thought to regulate uterine spiral artery remodeling, a process that allows for increased blood delivery to the fetal-placental unit. Impairment of uterine spiral ...
    • PHACTR1 Is a Genetic Susceptibility Locus for Fibromuscular Dysplasia Supporting Its Complex Genetic Pattern of Inheritance 

      Kiando, Soto Romuald; Tucker, Nathan R.; Castro-Vega, Luis-Jaime; Katz, Alexander; D’Escamard, Valentina; Tréard, Cyrielle; Fraher, Daniel; Albuisson, Juliette; Kadian-Dodov, Daniella; Ye, Zi; Austin, Erin; Yang, Min-Lee; Hunker, Kristina; Barlassina, Cristina; Cusi, Daniele; Galan, Pilar; Empana, Jean-Philippe; Jouven, Xavier; Gimenez-Roqueplo, Anne-Paule; Bruneval, Patrick; Hyun Kim, Esther Soo; Olin, Jeffrey W.; Gornik, Heather L.; Azizi, Michel; Plouin, Pierre-François; Ellinor, Patrick T.; Kullo, Iftikhar J.; Milan, David J.; Ganesh, Santhi K.; Boutouyrie, Pierre; Kovacic, Jason C.; Jeunemaitre, Xavier; Bouatia-Naji, Nabila (Public Library of Science, 2016)
      Fibromuscular dysplasia (FMD) is a nonatherosclerotic vascular disease leading to stenosis, dissection and aneurysm affecting mainly the renal and cerebrovascular arteries. FMD is often an underdiagnosed cause of hypertension ...
    • Systems Pharmacology and Rational Polypharmacy: Nitric Oxide−Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case 

      Garmaroudi, Farshid S.; Handy, Diane E.; Liu, Yang-Yu; Loscalzo, Joseph (Public Library of Science, 2016)
      Impaired nitric oxide (NO˙)-cyclic guanosine 3', 5'-monophosphate (cGMP) signaling has been observed in many cardiovascular disorders, including heart failure and pulmonary arterial hypertension. There are several enzymatic ...
    • Time to Decide? Dynamical Analysis Predicts Partial Tip/Stalk Patterning States Arise during Angiogenesis 

      Venkatraman, Lakshmi; Regan, Erzsébet Ravasz; Bentley, Katie (Public Library of Science, 2016)
      Angiogenesis is a highly dynamic morphogenesis process; however, surprisingly little is known about the timing of the different molecular processes involved. Although the role of the VEGF-notch-DLL4 signaling pathway has ...