Browsing Harvard Medical School by Keyword "autoimmunity"

Now showing items 1-12 of 12

    • Adaptive Autoimmunity and Foxp3-Based Immunoregulation in Zebrafish 

      Quintana, Francisco Javier; Iglesias, Antonio H.; Farez, Mauricio F.; Caccamo, Mario; Burns, Evan J.; Kassam, Nasim; Oukka, Mohamed; Weiner, Howard Lee (Public Library of Science, 2010)
      Background: Jawed vertebrates generate their immune-receptor repertoire by a recombinatorial mechanism that has the potential to produce harmful autoreactive lymphocytes. In mammals, peripheral tolerance to self-antigens ...

    • Catastrophic NAD+ Depletion in Activated T Lymphocytes Through Nampt Inhibition Reduces Demyelination and Disability in EAE 

      Bruzzone, Santina; Fruscione, Floriana; Morando, Sara; Ferrando, Tiziana; Poggi, Alessandro; Garuti, Anna; D'Urso, Agustina; Selmo, Martina; Benvenuto, Federica; Cea, Michele; Zoppoli, Gabriele; Moran, Eva; Soncini, Debora; Ballestrero, Alberto; Sordat, Bernard; Patrone, Franco; Uccelli, Antonio; Nencioni, Alessio; Mostoslavsky, Raul (Public Library of Science, 2009)
      Nicotinamide phosphoribosyltransferase (Nampt) inhibitors such as FK866 are potent inhibitors of NAD+ synthesis that show promise for the treatment of different forms of cancer. Based on Nampt upregulation in activated T ...

    • Effective Detection of Human Leukocyte Antigen Risk Alleles in Celiac Disease Using Tag Single Nucleotide Polymorphisms 

      Monsuur, Alienke J.; Zhernakova, Alexandra; Pinto, Dalila; Verduijn, Willem; Romanos, Jihane; Auricchio, Renata; Lopez, Ana; van Heel, David A.; Crusius, J. Bart A; Wijmenga, Cisca; de Bakker, Paul I Wen (Public Library of Science, 2008)
      Background: The HLA genes, located in the MHC region on chromosome 6p21.3, play an important role in many autoimmune disorders, such as celiac disease (CD), type 1 diabetes (T1D), rheumatoid arthritis, multiple sclerosis, ...

    • Exploring the role of mononuclear phagocytes in the epididymis 

      Da Silva, Nicolas; Smith, Tegan B (Medknow Publications & Media Pvt Ltd, 2015)
      The onslaught of foreign antigens carried by spermatozoa into the epididymis, an organ that has not demonstrated immune privilege, a decade or more after the establishment of central immune tolerance presents a unique ...

    • Gene Network Analysis of Bone Marrow Mononuclear Cells Reveals Activation of Multiple Kinase Pathways in Human Systemic Lupus Erythematosus 

      Nakou, Magdalene; Bertsias, George; Stagakis, Ilias; Centola, Michael; Tassiulas, Ioannis; Hatziapostolou, Maria; Kritikos, Iraklis; Goulielmos, George; Boumpas, Dimitrios T.; Iliopoulos, Dimitrios (Public Library of Science, 2010)
      Background: Gene profiling studies provide important information for key molecules relevant to a disease but are less informative of protein-protein interactions, post-translational modifications and regulation by targeted ...

    • Genome-Wide Expression Profiling of Five Mouse Models Identifies Similarities and Differences with Human Psoriasis 

      Swindell, William R.; Johnston, Andrew; Carbajal, Steve; Han, Gangwen; Wohn, Christian; Lu, Jun; Xing, Xianying; Nair, Rajan P.; Voorhees, John J.; Elder, James T.; Wang, Xiao-Jing; Sano, Shigetoshi; Prens, Errol P.; DiGiovanni, John; Pittelkow, Mark R.; Ward, Nicole L.; Gudjonsson, Johann E. (Public Library of Science, 2011)
      Development of a suitable mouse model would facilitate the investigation of pathomechanisms underlying human psoriasis and would also assist in development of therapeutic treatments. However, while many psoriasis mouse ...

    • A gut feeling about arthritis 

      Mathis, Diane (eLife Sciences Publications, Ltd, 2013)
      The gut microbiota of patients recently diagnosed with rheumatoid arthritis is enriched in microbes belonging to the Prevotella genus.

    • HSP60 as a Target of Anti-Ergotypic Regulatory T Cells 

      Quintana, Francisco Javier; Mimran, Avishai; Carmi, Pnina; Mor, Felix; Cohen, Irun R. (Public Library of Science, 2008)
      The 60 kDa heat shock protein (HSP60) has been reported to influence T-cell responses in two ways: as a ligand of toll-like receptor 2 signalling and as an antigen. Here we describe a new mechanism of T-cell immuno-regulation ...

    • Ipilimumab in the treatment of metastatic melanoma: management of adverse events 

      Della Vittoria Scarpati, Giuseppina; Fusciello, Celeste; Perri, Francesco; Sabbatino, Francesco; Ferrone, Soldano; Carlomagno, Chiara; Pepe, Stefano (Dove Medical Press, 2014)
      Recently, “ipilimumab,” an anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) monoclonal antibody, has been demonstrated to improve overall survival in metastatic melanoma. “CTLA-4” is an immune-checkpoint molecule that ...

    • Network Theory Analysis of Antibody-Antigen Reactivity Data: The Immune Trees at Birth and Adulthood 

      Madi, Asaf; Kenett, Dror Y.; Bransburg-Zabary, Sharron; Merbl, Yifat Haya; Quintana, Francisco Javier; Tauber, Alfred I.; Cohen, Irun R.; Ben-Jacob, Eshel (Public Library of Science, 2011)
      Motivation: New antigen microarray technology enables parallel recording of antibody reactivities with hundreds of antigens. Such data affords system level analysis of the immune system’s organization using methods and ...

    • Plxnd1 Expression in Thymocytes Regulates Their Intrathymic Migration While That in Thymic Endothelium Impacts Medullary Topology 

      Choi, Young I.; Duke-Cohan, Jonathan S.; Tan, Jing; Gui, Jingang; Singh, Manvendra K.; Epstein, Jonathan A.; Reinherz, Ellis L. (Frontiers Media S.A., 2013)
      An important role for plexinD1 in thymic development is inferred from studies of germline Plxnd1 knockout (KO) mice where mislocalized CD69+ thymocytes as well as ectopic thymic subcapsular medullary structures were observed. ...

    • Systems biology approaches for the study of multiple sclerosis 

      Quintana, Francisco J; Farez, Mauricio F; Weiner, Howard L (Blackwell Publishing Ltd, 2008)
      Multiple sclerosis (MS) is a progressive neurological disease caused by an autoimmune attack to the central nervous system (CNS). MS is thought to result from a complex interaction between genetic and environmental factors. ...