Browsing Harvard Medical School by Keyword "biological sciences"

Now showing items 1-3 of 3

    • IKK\(\beta\) Regulates Essential Functions of the Vascular Endothelium Through Kinase-Dependent and -Independent Pathways 

      Ashida, Noboru; SenBanerjee, Sucharita B.; Kodama, Shohta; Foo, Shi Yin; Coggins, Matthew Peter; Spencer, Joel A.; Zamiri, Parisa; Shen, Dongxiao; Li, Ling; Sciuto, Tracey; Dvorak, Ann Marie; Gerszten, Robert Edgardo; Lin, Charles P.; Karin, Michael; Rosenzweig, Anthony (Nature Publishing Group, 2011)
      Vascular endothelium provides a selective barrier between the blood and tissues, participates in wound healing and angiogenesis, and regulates tissue recruitment of inflammatory cells. Nuclear factor (NF)- \(\kappa\)B ...

    • Substrate Docking to γ-Secretase Allows Access of γ-Secretase Modulators to an Allosteric Site 

      Uemura, Kengo; Farner, Katherine C.; Hashimoto, Tadafumi; Nasser-Ghodsi, Navine; Wolfe, Michael S.; Koo, Edward H.; Hyman, Bradley Theodore; Berezovska, Oksana (Nature Publishing Group, 2010)
      γ-Secretase generates the peptides of Alzheimer's disease, \(Aβ_{40}\) and \(Aβ_{42}\), by cleaving the amyloid precursor protein within its transmembrane domain. γ-Secretase also cleaves numerous other substrates, raising ...

    • Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation 

      Chang, Hao-Ming; Martinez, Natalia J; Thornton, James Edward; Gregory, Richard Ian (Nature Publishing Group, 2012)
      Pluripotent embryonic stem cells (ESCs) have a shortened cell cycle that enables their rapid proliferation. The ESC-specific miR-290 and miR-302 microRNA families promote proliferation whereas let-7 microRNAs inhibit ...