Browsing Harvard Medical School by Keyword "bone lead"

Now showing items 1-7 of 7

    • Association of Cumulative Lead Exposure with Parkinson’s Disease 

      Weisskopf, Marc G.; Weuve, Jennifer Lynn; Nie, Huiling; Saint-Hilaire, Marie-Helene; Sudarsky, Lewis Richard; Simon, David K.; Hersh, Bonnie Patricia; Schwartz, Joel David; Wright, Robert O.; Hu, Howard (National Institute of Environmental Health Sciences, 2010)
      Background: Research using reconstructed exposure histories has suggested an association between heavy metal exposures, including lead, and Parkinson’s disease (PD), but the only study that used bone lead, a biomarker of ...

    • A delta-aminolevulinic acid dehydratase (ALAD) polymorphism may modify the relationship of low-level lead exposure to uricemia and renal function: the normative aging study. 

      Wu, Ming-Tsang; Kelsey, Karl; Schwartz, Joel David; Sparrow, David; Weiss, Scott Tillman; Hu, Howard (2003)
      In this study we investigated whether a known delta-aminolevulinic acid dehydratase (ALAD) exon 4 polymorphism has a modifying effect on the association of blood or bone lead level with uricemia and indices of renal function ...

    • Determinants of Bone and Blood Lead Levels among Minorities Living in the Boston Area 

      Lin, Charles; Kim, Rokho; Tsaih, Shirng-Wern; Sparrow, David; Hu, Howard (National Institue of Environmental Health Sciences, 2004)
      We measured blood and bone lead levels among minority individuals who live in some of Boston’s neighborhoods with high minority representation. Compared with samples of predominantly white subjects we had studied before, ...

    • Influence of Prenatal Lead Exposure on Genomic Methylation of Cord Blood DNA 

      Pilsner, J. Richard; Hu, Howard; Sánchez, Brisa N.; Cantonwine, David; Lazarus, Alicia; Lamadrid-Figueroa, Héctor; Mercado-García, Adriana; Téllez-Rojo, Martha Maria; Hernández-Avila, Mauricio; Ettinger, Adrienne S; Wright, Robert O. (National Institute of Environmental Health Sciences, 2009)
      Background: Fetal lead exposure is associated with adverse pregnancy outcomes and developmental and cognitive deficits; however, the mechanism(s) by which lead-induced toxicity occurs remains unknown. Epigenetic fetal ...

    • Lead, Diabetes, Hypertension, and Renal Function: The Normative Aging Study 

      Tsaih, Shirng-Wern; Korrick, Susan Abigail; Schwartz, Joel David; Amarasiriwardena, Chitra J.; Aro, Antonio; Sparrow, David; Hu, Howard (National Institue of Environmental Health Sciences, 2004)
      In this prospective study, we examined changes in renal function during 6 years of follow-up in relation to baseline lead levels, diabetes, and hypertension among 448 middle-age and elderly men, a subsample of the Normative ...

    • Proton Magnetic Resonance Spectroscopic Evidence of Glial Effects of Cumulative Lead Exposure in the Adult Human Hippocampus 

      Weisskopf, Marc G.; Hu, Howard; Sparrow, David; Lenkinski, Robert E.; Wright, Robert O. (National Institute of Environmental Health Sciences, 2007)
      Background: Exposure to lead is known to have adverse effects on cognition in several different populations. Little is known about the underlying structural and functional correlates of such exposure in humans. Objectives: ...

    • Stress as a Potential Modifier of the Impact of Lead Levels on Blood Pressure: The Normative Aging Study 

      Peters, Junenette L.; Kubzansky, Laura Diane; McNeely, Eileen; Schwartz, Joel David; Spiro, Avron; Sparrow, David; Wright, Robert O.; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2007)
      Background: Lead exposure and psychological stress have been independently associated with hypertension in various populations, and animal studies suggest that when they co-occur, their effects may be exacerbated. Objectives: ...