Browsing Harvard Medical School by Keyword "immunosenescence"

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    • BTLA expression declines on B cells of the aged and is associated with low responsiveness to the trivalent influenza vaccine 

      Kannan, Senthil; Kurupati, Raj K.; Doyle, Susan A.; Freeman, Gordon J.; Schmader, Kenneth E.; Ertl, Hildegund C.J. (Impact Journals LLC, 2015)
      Virus-neutralizing antibody and B cell responses to influenza A viruses were measured in 35 aged and 28 middle-aged individuals following vaccination with the 2012 and 2013 trivalent inactivated influenza vaccines. Antibody ...

    • Sirt6 regulates dendritic cell differentiation, maturation, and function 

      Lasigliè, Denise; Boero, Silvia; Bauer, Inga; Morando, Sara; Damonte, Patrizia; Cea, Michele; Monacelli, Fiammetta; Odetti, Paizio; Ballestrero, Alberto; Uccelli, Antonio; Mostoslavsky, Raul; Poggi, Alessandro; Nencioni, Alessio (Impact Journals LLC, 2016)
      Dendritic cells (DCs) are antigen-presenting cells that critically influence decisions about immune activation or tolerance. Impaired DC function is at the core of common chronic disorders and contributes to reduce ...