Browsing Harvard Medical School by Keyword "ubiquitin"
Now showing items 1-6 of 6
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The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium
(eLife Sciences Publications, Ltd, 2014)The primary cilium has an important role in signaling; defects in structure are associated with a variety of human diseases. Much of the most basic biology of this organelle is poorly understood, even basic mechanisms, ... -
NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1
(MDPI, 2013)The principal Epstein-Barr virus (EBV) oncoprotein, Latent Membrane Protein 1 (LMP1), is expressed in most EBV-associated human malignancies. LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive ... -
The Role of the Ubiquitination–Proteasome Pathway in Breast Cancer: Use of Mouse Models for Analyzing Ubiquitination Processes
(BioMed Central, 2003)Turnover of several regulatory proteins results from targeted destruction via ubiquitination and subsequent degradation through the proteosome. The timely and irreversible degradation of critical regulators is essential ... -
Screening of DUB activity and specificity by MALDI-TOF mass spectrometry
(2014)Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and are attractive drug targets. ... -
Thiostrepton interacts covalently with Rpt subunits of the 19S proteasome and proteasome substrates
(John Wiley & Sons, Ltd, 2015)Here, we report a novel mechanism of proteasome inhibition mediated by Thiostrepton (Thsp), which interacts covalently with Rpt subunits of the 19S proteasome and proteasome substrates. We identified Thsp in a cell-based ... -
Ubiquitin Signaling: Extreme Conservation as a Source of Diversity
(MDPI, 2014)Around 2 × 103–2.5 × 103 million years ago, a unicellular organism with radically novel features, ancestor of all eukaryotes, dwelt the earth. This organism, commonly referred as the last eukaryotic common ancestor, contained ...