Now showing items 1-9 of 9

    • Aberrant regulation of FBW7 in cancer 

      Wang, Lixia; Ye, Xiantao; Liu, Yueyong; Wei, Wenyi; Wang, Zhiwei (Impact Journals LLC, 2014)
      FBW7 (F-box and WD repeat domain-containing 7) or Fbxw7 is a tumor suppressor, which promotes the ubiquitination and subsequent degradation of numerous oncoproteins including Mcl-1, Cyclin E, Notch, c- Jun, and c-Myc. In ...
    • Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling 

      Jung, H; Kim, B-G; Han, W H; Lee, J H; Cho, J-Y; Park, W S; Maurice, M M; Han, J-K; Lee, M J; Finley, D; Jho, E-h (Nature Publishing Group, 2013)
      Dishevelled (Dvl) is a key regulator of Wnt signaling both in the canonical and non-canonical pathways. Here we report the identification of a regulatory domain of ubiquitination (RDU) in the C-terminus of Dvl. Mutations ...
    • DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction 

      Wang, Zhiwei; Inuzuka, Hiroyuki; Zhong, Jiateng; Fukushima, Hidefumi; Wan, Lixin; Liu, Pengda; Wei, Wenyi (Impact Journals LLC, 2012)
      The Mdm2 oncoprotein promotes p53 ubiquitination and destruction. Yet, exact molecular mechanisms of Mdm2 destruction itself, under DNA damaging conditions, remain unclear. Recently, we identified SCFβ-TRCP as a novel E3 ...
    • G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L 

      Zhang, Tao; Dong, Kangyun; Liang, Wei; Xu, Daichao; Xia, Hongguang; Geng, Jiefei; Najafov, Ayaz; Liu, Min; Li, Yanxia; Han, Xiaoran; Xiao, Juan; Jin, Zhenzhen; Peng, Ting; Gao, Yang; Cai, Yu; Qi, Chunting; Zhang, Qing; Sun, Anyang; Lipinski, Marta; Zhu, Hong; Xiong, Yue; Pandolfi, Pier Paolo; Li, He; Yu, Qiang; Yuan, Junying (eLife Sciences Publications, Ltd, 2015)
      Autophagy is an important intracellular catabolic mechanism involved in the removal of misfolded proteins. Atg14L, the mammalian ortholog of Atg14 in yeast and a critical regulator of autophagy, mediates the production ...
    • Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2 

      Wang, Zhiwei; Inuzuka, Hiroyuki; Zhong, Jiateng; Liu, Pengda; Sarkar, Fazlul H.; Sun, Yi; Wei, Wenyi (Impact Journals LLC, 2012)
      The Skp2 (S-phase kinase associated protein 2) oncoprotein is often highly expressed in various types of human cancers. However, the mechanistic basis of its oncogenic function, as well as the upstream regulatory pathway(s) ...
    • Negative regulation of DAB2IP by Akt and SCFFbw7 pathways 

      Dai, Xiangping; North, Brian J.; Inuzuka, Hiroyuki (Impact Journals LLC, 2014)
      Deletion of ovarian carcinoma 2/disabled homolog 2 (DOC-2/DAB2) interacting protein (DAB2IP), is a tumor suppressor that serves as a scaffold protein involved in coordinately regulating cell proliferation, survival and ...
    • SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination 

      Wu, Xiaomian; Fukushima, Hidefumi; North, Brian J.; Nagaoka, Yoshiyuki; Nagashima, Katsuyuki; Deng, Feng; Okabe, Koji; Inuzuka, Hiroyuki; Wei, Wenyi (Impact Journals LLC, 2014)
      CYLD negatively regulates the NF-κB signaling pathway and osteoclast differentiation largely through antagonizing TNF receptor-associated factor (TRAF)-mediated K63-linkage polyubiquitination in osteoclast precursor cells. ...
    • SCFβ-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration 

      Zhong, Jiateng; Shaik, Shavali; Wan, Lixin; Tron, Adriana E.; Wang, Zhiwei; Sun, Liankun; Inuzuka, Hiroyuki; Wei, Wenyi (Impact Journals LLC, 2013)
      Metastasis suppressor 1 (MTSS1) is an important tumor suppressor protein, and loss of MTSS1 expression has been observed in several types of human cancers. Importantly, decreased MTSS1 expression is associated with more ...
    • SCFβ-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway 

      Liu, Jia; Wan, Lixin; Liu, Pengda; Inuzuka, Hiroyuki; Liu, Jiankang; Wang, Zhiwei; Wei, Wenyi (Impact Journals LLC, 2014)
      The HECT domain-containing ubiquitin E3 ligase NEDD4 is widely expressed in mammalian tissues and plays a crucial role in governing a wide spectrum of cellular processes including cell growth, tissue development and ...